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EQUIPE 3 : PHYSIOPATHOLOGIE DE L'AXE INTESTIN-CERVEAU
TEAM 3 : PHYSIOPATHOLOGY OF THE GUT BRAIN AXIS |
Mini CV
TCE INSERM
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Recherche/projet research/project
Role of immune-derived opioids in intestinal homeostasis
The visceral pain resulting from inflammation-induced neuronal firing is endogenously regulated by opioids locally released by effector CD4+ T lymphocytes generated in response to microbe-derived antigens. Our objective is to better define the role of immune-derived opioids in the intestinal homeostasis including physical barrier function, mucosal immunity, and enteric nervous system activity.
The visceral pain resulting from inflammation-induced neuronal firing is endogenously regulated by opioids locally released by effector CD4+ T lymphocytes generated in response to microbe-derived antigens. Our objective is to better define the role of immune-derived opioids in the intestinal homeostasis including physical barrier function, mucosal immunity, and enteric nervous system activity.
Production scientifique scientific production
- Basso L., J. Boue, K. Mahiddine, C. Blanpied, S. Robiou-du-Pont, N. Vergnolle, C. Deraison and G. Dietrich. 2016. Endogenous analgesia mediated by CD4+ T lymphocytes is dependent on enkephalins in mice. J. Neuro. Inflamm. 13:132.
- Boue J., L. Basso, N. Cenac, C. Blanpied, M. Rolli-Derkinderen, M. Neunlist, N. Vergnolle and G. Dietrich. 2014. Endogenous regulation of visceral pain via opioid production by colitogenic CD4+ T lymphocytes in mice. Gastroenterology. 146: 166-175.
