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CONTACTS
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EQUIPE 1 :SIGNAUX PROTÉOLYTIQUES DE L'INTESTIN
TEAM 1 : GUT PROTEASE SIGNALS |
Mini CV
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expertise
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Recherche/projet research/project
Proteases from epithelial cells, mediators of inflammation in IBD
Tissue homeostasis is disrupted in a number of chronic diseases. In particular, proteolytic homeostasis which plays major roles in tissue remodelling and in digestive organ functions, is disrupted in inflammatory bowel disease (IBD). Therefore, a better knowledge of the actors involved in proteolytic homeostasis is a major step towards disease comprehension and diagnostic. Two types of molecules regulate proteolytic homeostasis: proteases and protease inhibitors, defining the proteolytic status of the tissues. The characterization of the proteases hyperactive in the inflamed gut, their substrates, and the consequences of their increased activity will advance our knowledge of the biological cascades initiated by protease dysregulation in IBD. We expect of our analysis of protease hyperactivity to identify control points in the mechanisms of disease that could be addressed by the development of specific inhibitors, as the basis of novel therapeutic approaches for IBD.
Tissue homeostasis is disrupted in a number of chronic diseases. In particular, proteolytic homeostasis which plays major roles in tissue remodelling and in digestive organ functions, is disrupted in inflammatory bowel disease (IBD). Therefore, a better knowledge of the actors involved in proteolytic homeostasis is a major step towards disease comprehension and diagnostic. Two types of molecules regulate proteolytic homeostasis: proteases and protease inhibitors, defining the proteolytic status of the tissues. The characterization of the proteases hyperactive in the inflamed gut, their substrates, and the consequences of their increased activity will advance our knowledge of the biological cascades initiated by protease dysregulation in IBD. We expect of our analysis of protease hyperactivity to identify control points in the mechanisms of disease that could be addressed by the development of specific inhibitors, as the basis of novel therapeutic approaches for IBD.
Production scientifique scientific production
RCID ID : 0000-0002-9013-4592
https://pubmed-ncbi-nlm-nih-gov.proxy.insermbiblio.inist.fr/?term=deraison+C.&sort=date
Postoperative Ileus: a Pharmacological Perspective.
Buscail E, Deraison C. Br J Pharmacol. 2022 Jan 19. doi: 10.1111/bph.15800. Online ahead of print. PMID: 35048360 Review.
PAR-1 Antagonism to Promote Gut Mucosa Healing in Crohn's Disease Patients: A New Avenue for CVT120165.
Motta JP, Deraison C, Le Grand S, Le Grand B, Vergnolle N. Inflamm Bowel Dis. 2021 Nov 15;27(Suppl 2):S33-S37. doi: 10.1093/ibd/izab244. PMID: 34791291 Review.
Adipose-Derived Stem Cells in the Treatment of Perianal Fistulas in Crohn's Disease: Rationale, Clinical Results and Perspectives.
Buscail E, Le Cosquer G, Gross F, Lebrin M, Bugarel L, Deraison C, Vergnolle N, Bournet B, Gilletta C, Buscail L. Int J Mol Sci. 2021 Sep 15;22(18):9967. doi: 10.3390/ijms22189967. PMID: 34576129 Free PMC article. Review.
Peripheral Opioid Receptor Blockade Enhances Epithelial Damage in Piroxicam-Accelerated Colitis in IL-10-Deficient Mice.
Mas-Orea X, Sebert M, Benamar M, Petitfils C, Blanpied C, Saoudi A, Deraison C, Barreau F, Cenac N, Dietrich G. Int J Mol Sci. 2021 Jul 9;22(14):7387. doi: 10.3390/ijms22147387. PMID: 34299013 Free PMC article.
Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation.
Motta JP, Rolland C, Edir A, Florence AC, Sagnat D, Bonnart C, Rousset P, Guiraud L, Quaranta-Nicaise M, Mas E, Bonnet D, Verdu EF, McKay DM, Buscail E, Alric L, Vergnolle N, Deraison C. Mucosal Immunol. 2021 May;14(3):667-678. doi: 10.1038/s41385-021-00375-w. Epub 2021 Mar 5. PMID: 33674762 Free PMC article.
Colitis Linked to Endoplasmic Reticulum Stress Induces Trypsin Activity Affecting Epithelial Functions.
Solà Tapias N, Denadai-Souza A, Rolland-Fourcade C, Quaranta-Nicaise M, Blanpied C, Marcellin M, Edir A, Rolland C, Cirillo C, Dietrich G, Alric L, Portier G, Kirzin S, Bonnet D, Mas E, Burlet-Schiltz O, Deraison C, Bonnart C, Vergnolle N, Barreau F. J Crohns Colitis. 2021 Sep 25;15(9):1528-1541. doi: 10.1093/ecco-jcc/jjab035. PMID: 33609354
Gastrointestinal biofilms in health and disease.
Motta JP, Wallace JL, Buret AG, Deraison C, Vergnolle N. Nat Rev Gastroenterol Hepatol. 2021 May;18(5):314-334. doi: 10.1038/s41575-020-00397-y. Epub 2021 Jan 28. PMID: 33510461 Review.
Increased Mucosal Thrombin is Associated with Crohn's Disease and Causes Inflammatory Damage through Protease-activated Receptors Activation.
Motta JP, Palese S, Giorgio C, Chapman K, Denadai-Souza A, Rousset P, Sagnat D, Guiraud L, Edir A, Seguy C, Alric L, Bonnet D, Bournet B, Buscail L, Gilletta C, Buret AG, Wallace JL, Hollenberg MD, Oswald E, Barocelli E, Le Grand S, Le Grand B, Deraison C, Vergnolle N. J Crohns Colitis. 2021 May 4;15(5):787-799. doi: 10.1093/ecco-jcc/jjaa229. PMID: 33201214 Free PMC article.
Characterization of Human Colon Organoids From Inflammatory Bowel Disease Patients.
d'Aldebert E, Quaranta M, Sébert M, Bonnet D, Kirzin S, Portier G, Duffas JP, Chabot S, Lluel P, Allart S, Ferrand A, Alric L, Racaud-Sultan C, Mas E, Deraison C, Vergnolle N. Front Cell Dev Biol. 2020 Jun 4;8:363. doi: 10.3389/fcell.2020.00363. eCollection 2020. PMID: 32582690 Free PMC article.
Endogenous control of inflammatory visceral pain by T cell-derived opioids in IL-10-deficient mice.
Basso L, Benamar M, Mas-Orea X, Deraison C, Blanpied C, Cenac N, Saoudi A, Dietrich G. Neurogastroenterol Motil. 2020 Feb;32(2):e13743. doi: 10.1111/nmo.13743. Epub 2019 Oct 7. PMID: 31588671
Sexual dimorphism in PAR2-dependent regulation of primitive colonic cells.
Noguerol J, Roustan PJ, N'Taye M, Delcombel L, Rolland C, Guiraud L, Sagnat D, Edir A, Bonnart C, Denadai-Souza A, Deraison C, Vergnolle N, Racaud-Sultan C. Biol Sex Differ. 2019 Sep 6;10(1):47. doi: 10.1186/s13293-019-0262-6. PMID: 31492202 Free PMC article.
Active thrombin produced by the intestinal epithelium controls mucosal biofilms.
Motta JP, Denadai-Souza A, Sagnat D, Guiraud L, Edir A, Bonnart C, Sebbag M, Rousset P, Lapeyre A, Seguy C, Mathurine-Thomas N, Galipeau HJ, Bonnet D, Alric L, Buret AG, Wallace JL, Dufour A, Verdu EF, Hollenberg MD, Oswald E, Serino M, Deraison C, Vergnolle N. Nat Commun. 2019 Jul 19;10(1):3224. doi: 10.1038/s41467-019-11140-w. PMID: 31324782 Free PMC article.
Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2.
Caminero A, McCarville JL, Galipeau HJ, Deraison C, Bernier SP, Constante M, Rolland C, Meisel M, Murray JA, Yu XB, Alaedini A, Coombes BK, Bercik P, Southward CM, Ruf W, Jabri B, Chirdo FG, Casqueiro J, Surette MG, Vergnolle N, Verdu EF. Nat Commun. 2019 Mar 13;10(1):1198. doi: 10.1038/s41467-019-09037-9. PMID: 30867416 Free PMC article.
Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease.
Denadai-Souza A, Bonnart C, Tapias NS, Marcellin M, Gilmore B, Alric L, Bonnet D, Burlet-Schiltz O, Hollenberg MD, Vergnolle N, Deraison C. Sci Rep. 2018 May 18;8(1):7834. doi: 10.1038/s41598-018-26282-y. PMID: 29777136 Free PMC article.
Mobilization of CD4+ T lymphocytes in inflamed mucosa reduces pain in colitis mice: toward a vaccinal strategy to alleviate inflammatory visceral pain.
Basso L, Boué J, Augé C, Deraison C, Blanpied C, Cenac N, Lluel P, Vergnolle N, Dietrich G. Pain. 2018 Feb;159(2):331-341. doi: 10.1097/j.pain.0000000000001103. PMID: 29140925
Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study.
Denadai-Souza A, Ribeiro CM, Rolland C, Thouard A, Deraison C, Scavone C, Gonzalez-Dunia D, Vergnolle N, Avellar MCW. Arthritis Res Ther. 2017 Jun 6;19(1):124. doi: 10.1186/s13075-017-1326-9. PMID: 28587618 Free PMC article.
Tryptase was inhibited by two approaches: a lentivirus-mediated heterologous expression of the human endogenous tryptase inhibitor, sperm-associated antigen 11B isoform C (hSPAG11B/C), or a chronic treatment with the synthetic tryptase inhibitor APC366. ...The intra …
Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection.
Gobbetti T, Dalli J, Colas RA, Federici Canova D, Aursnes M, Bonnet D, Alric L, Vergnolle N, Deraison C, Hansen TV, Serhan CN, Perretti M. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3963-3968. doi: 10.1073/pnas.1617290114. Epub 2017 Mar 29. PMID: 28356517 Free PMC article.
Epithelial expression and function of trypsin-3 in irritable bowel syndrome.
Rolland-Fourcade C, Denadai-Souza A, Cirillo C, Lopez C, Jaramillo JO, Desormeaux C, Cenac N, Motta JP, Larauche M, Taché Y, Vanden Berghe P, Neunlist M, Coron E, Kirzin S, Portier G, Bonnet D, Alric L, Vanner S, Deraison C, Vergnolle N. Gut. 2017 Oct;66(10):1767-1778. doi: 10.1136/gutjnl-2016-312094. Epub 2017 Jan 17. PMID: 28096305 Free PMC article.
Endogenous analgesia mediated by CD4(+) T lymphocytes is dependent on enkephalins in mice.
Basso L, Boué J, Mahiddine K, Blanpied C, Robiou-du-Pont S, Vergnolle N, Deraison C, Dietrich G. J Neuroinflammation. 2016 Jun 1;13(1):132. doi: 10.1186/s12974-016-0591-x. PMID: 27245576 Free PMC article.
Motta JP & Bermúdez-Humarán LG, Deraison C, Martin L, Rolland C, Rousset P, Boue J, Dietrich G, Chapman K, Kharrat P, Vinel JP, Alric L, Mas E, Sallenave JM, Langella P, Vergnolle N. Food-grade bacteria expressing elafin protect against inflammation and restore colon homeostasis. Sci Transl Med. 2012 31;4(158)
Serine protease inhibitors protect better than IL-10 and TGF-β anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci.
Bermúdez-Humarán LG, Motta JP, Aubry C, Kharrat P, Rous-Martin L, Sallenave JM, Deraison C, Vergnolle N, Langella P. Microb Cell Fact. 2015 Feb 26;14:26. doi: 10.1186/s12934-015-0198-4. PMID: 25889561 Free PMC article.
Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome.
Furio L, de Veer S, Jaillet M, Briot A, Robin A, Deraison C, Hovnanian A. J Exp Med. 2014 Mar 10;211(3):499-513. doi: 10.1084/jem.20131797. Epub 2014 Feb 17. PMID: 24534191 Free PMC article.
Engineering lactococci and lactobacilli for human health.
Bermúdez-Humarán LG, Aubry C, Motta JP, Deraison C, Steidler L, Vergnolle N, Chatel JM, Langella P. Curr Opin Microbiol. 2013 Jun;16(3):278-83. doi: 10.1016/j.mib.2013.06.002. Epub 2013 Jul 11. PMID: 23850097 Review.
Food-grade bacteria expressing elafin protect against inflammation and restore colon homeostasis.
Motta JP, Bermúdez-Humarán LG, Deraison C, Martin L, Rolland C, Rousset P, Boue J, Dietrich G, Chapman K, Kharrat P, Vinel JP, Alric L, Mas E, Sallenave JM, Langella P, Vergnolle N. Sci Transl Med. 2012 Oct 31;4(158):158ra144. doi: 10.1126/scitranslmed.3004212. PMID: 23115353
https://pubmed-ncbi-nlm-nih-gov.proxy.insermbiblio.inist.fr/?term=deraison+C.&sort=date
Postoperative Ileus: a Pharmacological Perspective.
Buscail E, Deraison C. Br J Pharmacol. 2022 Jan 19. doi: 10.1111/bph.15800. Online ahead of print. PMID: 35048360 Review.
PAR-1 Antagonism to Promote Gut Mucosa Healing in Crohn's Disease Patients: A New Avenue for CVT120165.
Motta JP, Deraison C, Le Grand S, Le Grand B, Vergnolle N. Inflamm Bowel Dis. 2021 Nov 15;27(Suppl 2):S33-S37. doi: 10.1093/ibd/izab244. PMID: 34791291 Review.
Adipose-Derived Stem Cells in the Treatment of Perianal Fistulas in Crohn's Disease: Rationale, Clinical Results and Perspectives.
Buscail E, Le Cosquer G, Gross F, Lebrin M, Bugarel L, Deraison C, Vergnolle N, Bournet B, Gilletta C, Buscail L. Int J Mol Sci. 2021 Sep 15;22(18):9967. doi: 10.3390/ijms22189967. PMID: 34576129 Free PMC article. Review.
Peripheral Opioid Receptor Blockade Enhances Epithelial Damage in Piroxicam-Accelerated Colitis in IL-10-Deficient Mice.
Mas-Orea X, Sebert M, Benamar M, Petitfils C, Blanpied C, Saoudi A, Deraison C, Barreau F, Cenac N, Dietrich G. Int J Mol Sci. 2021 Jul 9;22(14):7387. doi: 10.3390/ijms22147387. PMID: 34299013 Free PMC article.
Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation.
Motta JP, Rolland C, Edir A, Florence AC, Sagnat D, Bonnart C, Rousset P, Guiraud L, Quaranta-Nicaise M, Mas E, Bonnet D, Verdu EF, McKay DM, Buscail E, Alric L, Vergnolle N, Deraison C. Mucosal Immunol. 2021 May;14(3):667-678. doi: 10.1038/s41385-021-00375-w. Epub 2021 Mar 5. PMID: 33674762 Free PMC article.
Colitis Linked to Endoplasmic Reticulum Stress Induces Trypsin Activity Affecting Epithelial Functions.
Solà Tapias N, Denadai-Souza A, Rolland-Fourcade C, Quaranta-Nicaise M, Blanpied C, Marcellin M, Edir A, Rolland C, Cirillo C, Dietrich G, Alric L, Portier G, Kirzin S, Bonnet D, Mas E, Burlet-Schiltz O, Deraison C, Bonnart C, Vergnolle N, Barreau F. J Crohns Colitis. 2021 Sep 25;15(9):1528-1541. doi: 10.1093/ecco-jcc/jjab035. PMID: 33609354
Gastrointestinal biofilms in health and disease.
Motta JP, Wallace JL, Buret AG, Deraison C, Vergnolle N. Nat Rev Gastroenterol Hepatol. 2021 May;18(5):314-334. doi: 10.1038/s41575-020-00397-y. Epub 2021 Jan 28. PMID: 33510461 Review.
Increased Mucosal Thrombin is Associated with Crohn's Disease and Causes Inflammatory Damage through Protease-activated Receptors Activation.
Motta JP, Palese S, Giorgio C, Chapman K, Denadai-Souza A, Rousset P, Sagnat D, Guiraud L, Edir A, Seguy C, Alric L, Bonnet D, Bournet B, Buscail L, Gilletta C, Buret AG, Wallace JL, Hollenberg MD, Oswald E, Barocelli E, Le Grand S, Le Grand B, Deraison C, Vergnolle N. J Crohns Colitis. 2021 May 4;15(5):787-799. doi: 10.1093/ecco-jcc/jjaa229. PMID: 33201214 Free PMC article.
Characterization of Human Colon Organoids From Inflammatory Bowel Disease Patients.
d'Aldebert E, Quaranta M, Sébert M, Bonnet D, Kirzin S, Portier G, Duffas JP, Chabot S, Lluel P, Allart S, Ferrand A, Alric L, Racaud-Sultan C, Mas E, Deraison C, Vergnolle N. Front Cell Dev Biol. 2020 Jun 4;8:363. doi: 10.3389/fcell.2020.00363. eCollection 2020. PMID: 32582690 Free PMC article.
Endogenous control of inflammatory visceral pain by T cell-derived opioids in IL-10-deficient mice.
Basso L, Benamar M, Mas-Orea X, Deraison C, Blanpied C, Cenac N, Saoudi A, Dietrich G. Neurogastroenterol Motil. 2020 Feb;32(2):e13743. doi: 10.1111/nmo.13743. Epub 2019 Oct 7. PMID: 31588671
Sexual dimorphism in PAR2-dependent regulation of primitive colonic cells.
Noguerol J, Roustan PJ, N'Taye M, Delcombel L, Rolland C, Guiraud L, Sagnat D, Edir A, Bonnart C, Denadai-Souza A, Deraison C, Vergnolle N, Racaud-Sultan C. Biol Sex Differ. 2019 Sep 6;10(1):47. doi: 10.1186/s13293-019-0262-6. PMID: 31492202 Free PMC article.
Active thrombin produced by the intestinal epithelium controls mucosal biofilms.
Motta JP, Denadai-Souza A, Sagnat D, Guiraud L, Edir A, Bonnart C, Sebbag M, Rousset P, Lapeyre A, Seguy C, Mathurine-Thomas N, Galipeau HJ, Bonnet D, Alric L, Buret AG, Wallace JL, Dufour A, Verdu EF, Hollenberg MD, Oswald E, Serino M, Deraison C, Vergnolle N. Nat Commun. 2019 Jul 19;10(1):3224. doi: 10.1038/s41467-019-11140-w. PMID: 31324782 Free PMC article.
Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2.
Caminero A, McCarville JL, Galipeau HJ, Deraison C, Bernier SP, Constante M, Rolland C, Meisel M, Murray JA, Yu XB, Alaedini A, Coombes BK, Bercik P, Southward CM, Ruf W, Jabri B, Chirdo FG, Casqueiro J, Surette MG, Vergnolle N, Verdu EF. Nat Commun. 2019 Mar 13;10(1):1198. doi: 10.1038/s41467-019-09037-9. PMID: 30867416 Free PMC article.
Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease.
Denadai-Souza A, Bonnart C, Tapias NS, Marcellin M, Gilmore B, Alric L, Bonnet D, Burlet-Schiltz O, Hollenberg MD, Vergnolle N, Deraison C. Sci Rep. 2018 May 18;8(1):7834. doi: 10.1038/s41598-018-26282-y. PMID: 29777136 Free PMC article.
Mobilization of CD4+ T lymphocytes in inflamed mucosa reduces pain in colitis mice: toward a vaccinal strategy to alleviate inflammatory visceral pain.
Basso L, Boué J, Augé C, Deraison C, Blanpied C, Cenac N, Lluel P, Vergnolle N, Dietrich G. Pain. 2018 Feb;159(2):331-341. doi: 10.1097/j.pain.0000000000001103. PMID: 29140925
Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study.
Denadai-Souza A, Ribeiro CM, Rolland C, Thouard A, Deraison C, Scavone C, Gonzalez-Dunia D, Vergnolle N, Avellar MCW. Arthritis Res Ther. 2017 Jun 6;19(1):124. doi: 10.1186/s13075-017-1326-9. PMID: 28587618 Free PMC article.
Tryptase was inhibited by two approaches: a lentivirus-mediated heterologous expression of the human endogenous tryptase inhibitor, sperm-associated antigen 11B isoform C (hSPAG11B/C), or a chronic treatment with the synthetic tryptase inhibitor APC366. ...The intra …
Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection.
Gobbetti T, Dalli J, Colas RA, Federici Canova D, Aursnes M, Bonnet D, Alric L, Vergnolle N, Deraison C, Hansen TV, Serhan CN, Perretti M. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3963-3968. doi: 10.1073/pnas.1617290114. Epub 2017 Mar 29. PMID: 28356517 Free PMC article.
Epithelial expression and function of trypsin-3 in irritable bowel syndrome.
Rolland-Fourcade C, Denadai-Souza A, Cirillo C, Lopez C, Jaramillo JO, Desormeaux C, Cenac N, Motta JP, Larauche M, Taché Y, Vanden Berghe P, Neunlist M, Coron E, Kirzin S, Portier G, Bonnet D, Alric L, Vanner S, Deraison C, Vergnolle N. Gut. 2017 Oct;66(10):1767-1778. doi: 10.1136/gutjnl-2016-312094. Epub 2017 Jan 17. PMID: 28096305 Free PMC article.
Endogenous analgesia mediated by CD4(+) T lymphocytes is dependent on enkephalins in mice.
Basso L, Boué J, Mahiddine K, Blanpied C, Robiou-du-Pont S, Vergnolle N, Deraison C, Dietrich G. J Neuroinflammation. 2016 Jun 1;13(1):132. doi: 10.1186/s12974-016-0591-x. PMID: 27245576 Free PMC article.
Motta JP & Bermúdez-Humarán LG, Deraison C, Martin L, Rolland C, Rousset P, Boue J, Dietrich G, Chapman K, Kharrat P, Vinel JP, Alric L, Mas E, Sallenave JM, Langella P, Vergnolle N. Food-grade bacteria expressing elafin protect against inflammation and restore colon homeostasis. Sci Transl Med. 2012 31;4(158)
Serine protease inhibitors protect better than IL-10 and TGF-β anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci.
Bermúdez-Humarán LG, Motta JP, Aubry C, Kharrat P, Rous-Martin L, Sallenave JM, Deraison C, Vergnolle N, Langella P. Microb Cell Fact. 2015 Feb 26;14:26. doi: 10.1186/s12934-015-0198-4. PMID: 25889561 Free PMC article.
Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome.
Furio L, de Veer S, Jaillet M, Briot A, Robin A, Deraison C, Hovnanian A. J Exp Med. 2014 Mar 10;211(3):499-513. doi: 10.1084/jem.20131797. Epub 2014 Feb 17. PMID: 24534191 Free PMC article.
Engineering lactococci and lactobacilli for human health.
Bermúdez-Humarán LG, Aubry C, Motta JP, Deraison C, Steidler L, Vergnolle N, Chatel JM, Langella P. Curr Opin Microbiol. 2013 Jun;16(3):278-83. doi: 10.1016/j.mib.2013.06.002. Epub 2013 Jul 11. PMID: 23850097 Review.
Food-grade bacteria expressing elafin protect against inflammation and restore colon homeostasis.
Motta JP, Bermúdez-Humarán LG, Deraison C, Martin L, Rolland C, Rousset P, Boue J, Dietrich G, Chapman K, Kharrat P, Vinel JP, Alric L, Mas E, Sallenave JM, Langella P, Vergnolle N. Sci Transl Med. 2012 Oct 31;4(158):158ra144. doi: 10.1126/scitranslmed.3004212. PMID: 23115353
