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EQUIPE 6 INTERACTIONS ENTRE L'ENVIRONNEMENT ET L'ÉPITHÉLIUM INTESTINAL
TEAM 6 ENVIRONMENT & INTESTINAL EPITHELIUM INTERACTIONS |
MINI CV
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EXPERTISE
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Activités universitaires
- Janvier 2025 : membre ITA du comité d’évaluation Hcéres de l’Institut Gustave Roussy (Paris) régie par le Professeur Fabien Despas de la Faculté Santé de Toulouse
- 2022 à 2023 : mission d’investigations pour la création de la zootechnie de la Faculté Santé de Toulouse mandatée par le Doyen Philippe Pomar
Projets de recherche / modèles animaux et cellulaires
- Mucoviscidose intestinale ==> cohorte murine (Orléans) C57BL6
- Organoïdes des MICI et des PAFs ==> cohorte humaine BioDige (Recherche Clinique Purpan) + traitement médicamenteux (inhibiteur PI3k Alpha et Bétâ)
Techniques et méthodes
- Prélèvement sanguin, des organes et tissus en vue de leur analyse histologique, protéique avec techniques de culture cellulaire suite au prélèvement.
- Culture d’organoïdes
Production scientifique
“Cold-induced thermogenesis requires neutral-lipase-mediated intracellular lipolysis in brown adipocytes”
Etienne Mouisel, Anaïs Bodon, Christophe Noll, Stéphanie Cassant-Sourdy, Marie-Adeline Marques,Remy Flores-Flores, Elodie Riant, Camille Bergoglio, Pierre Vezin, Sylvie Caspar-Bauguil,Camille Fournes-Fraresso, Geneviève Tavernier, Khalil Acheikh Ibn Oumar, Pierre Gourdy, Denis P. Blondin,Pierre-Damien Denechaud, André C. Carpentier, and Dominique Langin
CELL METABOLISM 2024 Nov
“ChREBP is dispensable for the control of glucose homeostasis and energy balance”
Emeline Recazens, Geneviève Tavernier, Jérémy Dufau, Camille Bergoglio, Fadila Benhamed, Stéphanie Cassant-Sourdy, Marie-Adeline Marques, Sylvie Caspar-Bauguil1, Alice Brion, Laurent Monbrun, Renaud Dentin, Clara Ferrier, Mélanie Leroux, Pierre-Damien Denechaud, Cedric Moro, Jean-Paul Concordet, Catherine Postic, Etienne Mouisel, and Dominique Langin
JCI Insight 2021 Oct
“Pancreatic ductal adenocarcinoma requires tumour-intrisic PI3Kα activity to accelerate inflammatory
micrometastatic disease”
Thibault B., Ramos Delgado F, Pons-Tostivint E., Therville N., Cintas C., Arcucci S., Cassant-Sourdy S., Reyes-Castellanos G.Tosolini M., Villard A., Cayron C.,Baer R., Bertrand-Michel J., Pagan D., Yan H., Falcomata C., Bournet B., Delord JP., Aksoy E., Carrier A., Cordelier P., Saur D., Basset C. Guillermet-Guibert J.
EMBO MO MED 2021 Feb
“Pharmacological normalization of pancreatic cancer-associated fibroblast secretome impairs prometastatic dialogue with macrophages”
Samain Rémi, Brunel Alexia, Douche Thibaut, Fanjul Marjorie, Cassant-Sourdy Stéphanie, Rochotte Julia, Cros Jérôme, Neuzillet Cindy, Raffenne Jérôme, Duluc Camille, Perraud Aurelie, Nigri Jerome, Bieche Ivan, Ponzo Matteo, Carpentier Jerome, Cascone Ilaria, Tomasini Richard, Schmid, Herbert, Mathonnet Muriel, Nicolle Rémy, Bousquet Marie-Pierre, Martineau Yavn, Pyronnet Stephane, Jean Christine, Bousquet Corinne.
Cellular and Molecular Gastroenterology and Hepatology 2021 March
“Phosphorylation of the MNK1 substrate elF4E is not required for response to acute pancreatitis”
Alard Amandine, Strehaïno Manon, Müller Davis, Lasfargues Charline, Cassant-Sourdy Stéphanie, Jean Chrsitine, Bousquet Corinne, Martineau Yvan, Pyronnet Stéphane.
Pancreatology Article 2021 Fev.
“Fibroblastic FAK activity modifies Pancreatic Ductal Adenocarcinoma microenvironment and progression”
Sonia Zaghdoudi, Emilie Decaup, Rémi Samain, Stéphanie Cassant-Sourdy, Julia Rochotte, David Schlaepfer, Jérôme Cros, Cindy Neuzillet, Amandine Alard, Richard Tomasini, Aurélie Perraud, Muriel Mathonnet, Yvan Martineau, Stéphane Pyronnet, Corinne Bousquet, Christine Jean.
EMBO MO MED 2020 Sept
“Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism”
Farge T, Saland E, de Toni F, Aroua N, Hosseini M, Perry R, Bosc C, Sugita M, Stuani L, Fraisse M, Scotland S, Larrue C, Boutzen H, Féliu V, Nicolau-Travers ML, Cassant-Sourdy S, Broin N, David M, Serhan N, Sarry A, Tavitian S, Kaoma T, Vallar L, Iacovoni J, Linares LK, Montersino C, Castellano R, Griessinger E, Collette Y, Duchamp O, Barreira Y, Hirsch P, Palama T, Gales L, Delhommeau F, Garmy-Susini BH, Portais JC, Vergez F, Selak M, Danet-Desnoyers G, Carroll M, Récher C, Sarry JE.
Cancer Discov 2017 Jul
“Nucleolin Controls VEGF-D Expression in heat shock condition to promote Lymphatic Dilatation”
Florent Morfoisse, Florence Tatin, Fransky Hantelys, Aurélien Adoue, Anne-Catherine Helfer, Stéphanie Cassant-Sourdy, Françoise Pujol, Anne Gomez-Brouchet, Laetitia Ligat, Frédéric Lopez, Stéphane Pyronnet, and others, Barbara Garmy-Susini.
Cancer Res 2016 Aug
“Anti-metastatic potential of somatostatin analog SOM230 Indirect pharmacological targeting of pancreatic cancer-associated fibroblasts”
Moatassim-Billah S, Duluc C, Samain R, Jean C, Perraud A, Decaup E, Cassant-Sourdy S, Bakri Y, Selves J, Schmid H, Martineau Y, Mathonnet M, Pyronnet S, Bousquet C.
Oncotarget 2016 Jul
“Loss of Somatostatin Receptor Subtype 2 Promotes Growth of KRAS-Induced Pancreatic Tumors in Mice by Activating PI3K Signaling and Overexpression of CXCL16”
Chalabi-Dchar M, Cassant-Sourdy S, Duluc C, Fanjul M, Lulka H, Samain R, Roche C, Breibach F, Delisle MB, Poupot M, Dufresne M, Shimaoka T, Yonehara S, Mathonnet M, Pyronnet S, Bousquet C.
Gastroenterology 2015 Jun
“Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α”
Baer R, Cintas C, Dufresnes M, Cassant-Sourdy S, Schönhuber N, Planque L, Lulka H, Couderc B, Bousquet C, Garmy-Susini B, Vanhaesebroeck B, Pyronnet S, Saur D, Guillermet-Guibert J.
Genes Dev 2014 Dec
Etienne Mouisel, Anaïs Bodon, Christophe Noll, Stéphanie Cassant-Sourdy, Marie-Adeline Marques,Remy Flores-Flores, Elodie Riant, Camille Bergoglio, Pierre Vezin, Sylvie Caspar-Bauguil,Camille Fournes-Fraresso, Geneviève Tavernier, Khalil Acheikh Ibn Oumar, Pierre Gourdy, Denis P. Blondin,Pierre-Damien Denechaud, André C. Carpentier, and Dominique Langin
CELL METABOLISM 2024 Nov
“ChREBP is dispensable for the control of glucose homeostasis and energy balance”
Emeline Recazens, Geneviève Tavernier, Jérémy Dufau, Camille Bergoglio, Fadila Benhamed, Stéphanie Cassant-Sourdy, Marie-Adeline Marques, Sylvie Caspar-Bauguil1, Alice Brion, Laurent Monbrun, Renaud Dentin, Clara Ferrier, Mélanie Leroux, Pierre-Damien Denechaud, Cedric Moro, Jean-Paul Concordet, Catherine Postic, Etienne Mouisel, and Dominique Langin
JCI Insight 2021 Oct
“Pancreatic ductal adenocarcinoma requires tumour-intrisic PI3Kα activity to accelerate inflammatory
micrometastatic disease”
Thibault B., Ramos Delgado F, Pons-Tostivint E., Therville N., Cintas C., Arcucci S., Cassant-Sourdy S., Reyes-Castellanos G.Tosolini M., Villard A., Cayron C.,Baer R., Bertrand-Michel J., Pagan D., Yan H., Falcomata C., Bournet B., Delord JP., Aksoy E., Carrier A., Cordelier P., Saur D., Basset C. Guillermet-Guibert J.
EMBO MO MED 2021 Feb
“Pharmacological normalization of pancreatic cancer-associated fibroblast secretome impairs prometastatic dialogue with macrophages”
Samain Rémi, Brunel Alexia, Douche Thibaut, Fanjul Marjorie, Cassant-Sourdy Stéphanie, Rochotte Julia, Cros Jérôme, Neuzillet Cindy, Raffenne Jérôme, Duluc Camille, Perraud Aurelie, Nigri Jerome, Bieche Ivan, Ponzo Matteo, Carpentier Jerome, Cascone Ilaria, Tomasini Richard, Schmid, Herbert, Mathonnet Muriel, Nicolle Rémy, Bousquet Marie-Pierre, Martineau Yavn, Pyronnet Stephane, Jean Christine, Bousquet Corinne.
Cellular and Molecular Gastroenterology and Hepatology 2021 March
“Phosphorylation of the MNK1 substrate elF4E is not required for response to acute pancreatitis”
Alard Amandine, Strehaïno Manon, Müller Davis, Lasfargues Charline, Cassant-Sourdy Stéphanie, Jean Chrsitine, Bousquet Corinne, Martineau Yvan, Pyronnet Stéphane.
Pancreatology Article 2021 Fev.
“Fibroblastic FAK activity modifies Pancreatic Ductal Adenocarcinoma microenvironment and progression”
Sonia Zaghdoudi, Emilie Decaup, Rémi Samain, Stéphanie Cassant-Sourdy, Julia Rochotte, David Schlaepfer, Jérôme Cros, Cindy Neuzillet, Amandine Alard, Richard Tomasini, Aurélie Perraud, Muriel Mathonnet, Yvan Martineau, Stéphane Pyronnet, Corinne Bousquet, Christine Jean.
EMBO MO MED 2020 Sept
“Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism”
Farge T, Saland E, de Toni F, Aroua N, Hosseini M, Perry R, Bosc C, Sugita M, Stuani L, Fraisse M, Scotland S, Larrue C, Boutzen H, Féliu V, Nicolau-Travers ML, Cassant-Sourdy S, Broin N, David M, Serhan N, Sarry A, Tavitian S, Kaoma T, Vallar L, Iacovoni J, Linares LK, Montersino C, Castellano R, Griessinger E, Collette Y, Duchamp O, Barreira Y, Hirsch P, Palama T, Gales L, Delhommeau F, Garmy-Susini BH, Portais JC, Vergez F, Selak M, Danet-Desnoyers G, Carroll M, Récher C, Sarry JE.
Cancer Discov 2017 Jul
“Nucleolin Controls VEGF-D Expression in heat shock condition to promote Lymphatic Dilatation”
Florent Morfoisse, Florence Tatin, Fransky Hantelys, Aurélien Adoue, Anne-Catherine Helfer, Stéphanie Cassant-Sourdy, Françoise Pujol, Anne Gomez-Brouchet, Laetitia Ligat, Frédéric Lopez, Stéphane Pyronnet, and others, Barbara Garmy-Susini.
Cancer Res 2016 Aug
“Anti-metastatic potential of somatostatin analog SOM230 Indirect pharmacological targeting of pancreatic cancer-associated fibroblasts”
Moatassim-Billah S, Duluc C, Samain R, Jean C, Perraud A, Decaup E, Cassant-Sourdy S, Bakri Y, Selves J, Schmid H, Martineau Y, Mathonnet M, Pyronnet S, Bousquet C.
Oncotarget 2016 Jul
“Loss of Somatostatin Receptor Subtype 2 Promotes Growth of KRAS-Induced Pancreatic Tumors in Mice by Activating PI3K Signaling and Overexpression of CXCL16”
Chalabi-Dchar M, Cassant-Sourdy S, Duluc C, Fanjul M, Lulka H, Samain R, Roche C, Breibach F, Delisle MB, Poupot M, Dufresne M, Shimaoka T, Yonehara S, Mathonnet M, Pyronnet S, Bousquet C.
Gastroenterology 2015 Jun
“Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α”
Baer R, Cintas C, Dufresnes M, Cassant-Sourdy S, Schönhuber N, Planque L, Lulka H, Couderc B, Bousquet C, Garmy-Susini B, Vanhaesebroeck B, Pyronnet S, Saur D, Guillermet-Guibert J.
Genes Dev 2014 Dec
