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CHERCHEUR INSERM 
​DR2
Permanent researcher

contaCt

​​00 33 (0)5 62 74 45 07
EQUIPE 4 : METABOLISME DU FER: DE LA REGULATION A LA THERAPIE 
TEAM 4 :  IRON METABOLISM:FROM REGULATION TO THERAPY ​ 

Mini CV

  • Thèse obtenue en 1981 à l'Université de Paris VI
  • Post-doctorat à l'Université de Stanford, California, 1981-1985
  • Recrutée à l'Inserm en 1986
  • Actuellement DR2 Inserm
  • Membre élue de la CSS 3 (immunologie) 1991-1994
  • Membre élue de la CSS2 (immunologie) 2003-2007
  • Membre élue de la CT2 (génétique) 2003-2007
  • Membre élue du Comité Scientifique de la Faculté de Médecine de Toulouse-Purpan (depuis 2016)
  • Membre du Conseil Scientifique de la Fondation Paufique

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expertise


  • Métabolisme du fer
  • Hémochromatose et autres surcharges en fer héréditaires
  • Modèles expérimentaux de désordres du métabolisme du fer
  • Anémie inflammatoire
  • Perturbations du métabolisme du fer au cours des infections bactériennes
  • Génétique de la souris
  • Biologie moléculaire et cellulaire
  • Immunologie

PROJET DE Recherche  research project

Vers une meilleure compréhension du métabolisme du fer dans les conditions physiologiques et pathologiques

Iron metabolism in health and disease

Production scientifique DANS LE DOMAINE scientific production in the iron field 

  1. Latour C, Besson-Fournier C, Gourbeyre O, Meynard D, Roth MP, Coppin H. Deletion of BMP6 worsens the phenotype of HJV-deficient mice and attenuates hepcidin levels reached after LPS challenge. Blood 2017, 130:2339-2343.
  2. Besson-Fournier C, Gineste A, Latour C, Gourbeyre O, Meynard D, Martin P, Oswald E, Coppin H, Roth MP. Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B. Blood 2017, 129:533-536.
  3. Latour C, Wlodarczyk MF, Jung G, Gineste A, Blanchard N, Ganz T, Roth MP, Coppin H, Kautz L. Erythroferrone contributes to hepcidin repression in a mouse model of malarial anemia. Haematologica 2017, 102:60-68.
  4. Besson-Fournier C, Martinez M, Vinel JP, Aguilar-Martinez P, Coppin H, Roth MP. Further support for the association of GNPAT variant rs11558492 with severe iron overload in hemochromatosis. Hepatology 2016, 63:2054-2055.
  5. Latour C, Besson-Fournier C, Meynard D, Silvestri L, Gourbeyre O, Aguilar-Martinez P, Schmidt PJ, Fleming MD, Roth MP, Coppin H. Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin. Hepatology 2016, 63:126-37.
  6. Gineste A, Martin P, Oswald E, Coppin H, Roth MP. Evidence for IL-6/STAT3-independent induction of lipocalin-2 in the liver of mice infected with Escherichia coli. Hepatology 2016, 63: 673-674.
  7. Nai A, Rubio A, Campanella A, Gourbeyre O, Artuso I, Bordini J, Gineste A, Latour C, Besson-Fournier C, Lin HY, Coppin H, Roth MP, Camaschella C, Silvestri L, Meynard D. Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice. Blood 2016, 127:2327-36.
  8. de Tayrac M, Roth MP, Jouanolle AM, Coppin H, le Gac G, Piperno A, Férec C, Pelucchi S, Scotet V, Bardou-Jacquet E, Ropert M, Bouvet R, Génin E, Mosser J, Deugnier Y. Genome-wide association study identifies TF as a significant modifier gene of iron metabolism in HFE hemochromatosis. J Hepatol 2015, 62:664-72.
  9. Picard E, Le Rouzic Q, Oudar A, Berdugo M, El Sanharawi M, Andrieu-Soler C, Naud MC, Jonet L, Latour C, Klein C, Galiacy S, Malecaze F, Coppin H, Roth MP, Jeanny JC, Courtois Y, Behar-Cohen F. Targeting iron-mediated retinal degeneration by local delivery of transferrin. Free Radic Biol Med 2015, 89:1105-21.
  10. Latour C, Kautz L, Besson-Fournier C, Island ML, Canonne-Hergaux F, Loréal O, Ganz T, Coppin H, Roth MP. Testosterone perturbs systemic iron balance through activation of EGFR signaling in the liver and repression of hepcidin. Hepatology 2014, 59:683-94.
  11. Poli M, Asperti M, Naggi A, Campostrini N, Girelli D, Corbella M, Benzi M, Besson-Fournier C, Coppin H, Maccarinelli F, Finazzi D, Arosio P.
    Glycol-split nonanticoagulant heparins are inhibitors of hepcidin expression in vitro and in vivo. Blood 2014, 123:1564-73.
  12. Besson-Fournier C, Latour C, Kautz L, Bertrand J, Ganz T, Roth MP, Coppin H. Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling. Blood 2012, 120:431-9.
  13. Kautz L, Besson C, Meynard D, Latour C, Roth MP, Coppin H. Iron overload induces Bmp6 expression in the liver but not in the duodenum. Haematologica 2011, 96: 199-203.
  14. Gutierrez L, Quintana C, Patino C, Bueno J, Coppin H, Roth MP, Lazaro FJ. Iron speciation study in Hfe knockout mice tissues: magnetic and ultrastructural characterization. Biochim Biophys Acta 2009, 1792: 541-547.
  15. Kautz L, Meynard D, Besson-Fournier C, Darnaud V, Al Saati T, Coppin H, Roth MP. BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression. Blood 2009, 114: 2515-20.
  16. Meynard D, Kautz L, Darnaud V, Canonne-Hergaux F, Coppin H, Roth MP. Lack of bone morphogenetic protein BMP6 induces massive iron overload. Nature Genetics 2009, 41: 478-481.
  17. Kautz L, Meynard D, Monnier A, Darnaud V, Bouvet R, Wang RH, Deng C, Vaulont S, Mosser J, Coppin H, Roth MP. Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 2008, 112: 1503-1509.
  18. Coppin H, Darnaud V, Kautz L, Meynard D, Aubry M, Mosser J, Martinez M, Roth MP. Gene expression profiling of Hfe-/- liver and duodenum in mouse strains with differing susceptibilities to iron loading; identification of transcriptional regulatory targets of Hfe and potential hemochromatosis modifiers. Genome Biology 2007, 8: R221.
  19. Rohrlich PS, Fazilleau N, Ginhoux F, Firat H, Michel F, Cochet M, Laham N, Roth MP, Pascolo S, Nato F, Coppin H, Charneau P, Danos O, Acuto O, Ehrlich R, Kanellopoulos J, Lemonnier FA. Direct recognition by alpha beta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function. PNAS 2005, 102: 12855-12860.
  20. Bensaid M, Fruchon S, Coppin H, Roth MP. Genes for gestational iron loading? Gastroenterology 2004, 127: 1861-1862.
  21. Bensaid M, Fruchon S, Mazères C, Bahram S, Roth MP, Coppin H. Multigenic control of hepatic iron loading in a murine model of hemochromatosis. Gastroenterology 2004, 126: 1400-1408.
  22. Courselaud B, Troadec MB, Fruchon S, Ilyin G, Borot N, Leroyer P, Coppin H, Brissot P, Roth MP, Loreal O. Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice. Blood Cells Mol Dis 2004, 32: 283-289.
  23. Coppin H, Bensaid M, Fruchon S, Borot N, Blanche H, Roth MP. Longevity is not affected in carriers of the hemochromatosis gene C282Y mutation: a study of 492 centenarians. Br Med J 2003, 327: 132-133.
  24. Fruchon S, Bensaid M, Borot N, Roth MP, Coppin H. Use of denaturing HPLC and a heteroduplex generator to detect the HFE C282Y mutation associated with genetic hemochromatosis. Clin Chem 2003, 49: 822-824.
  25. Dupic F, Fruchon S, Bensaid M, Loreal O, Brissot P, Borot N, Roth MP, Coppin H. Duodenal mRNA expression of iron-related genes in response to iron loading and iron deficiency in four strains of mice. Gut 2002, 51: 648-653.
  26. Dupic F, Fruchon S, Bensaid M, Borot N, Radosavljevic O, Loreal O, Brissot P, Gilfillan S, Bahram S, Coppin H, Roth MP. Inactivation of the hemochromatosis gene differentially regulates duodenal expression of iron-related mRNAs between mouse strains. Gastroenterology 2002, 122: 745-751.
  27. Robson KJH, Merryweather-Clarke AT, Pointon JJ, Shearman JD, Halsall DJ, Kelly A, Cox TM, Rosenberg WM, Howell M, Eccles D, Patch C, Fowler AV, Wallace DF, Camaschella C, Roetto A, Zecchina G, De Gobbi M, Gasparini P, Cadet E, Vandwalle JL, Capron D, Rochette J, Borot N, Demangel C, Dery R, Vinel JP, Pascal JP, Coppin H, Roth MP. Diagnosis and management of haemochromatosis since the discovery of the HFE gene: a European experience. British J Haematol 2000, 108:31-39.
  28. Merryweather-Clarke AT, Pointon JJ, Shearman JD, Robson KJ, Jouanolle AM, Mosser A, David V, Le Gall JY, Halsall DJ, Elsey TS, Kelly A, Cox TM, Clare M, Bomford A, Vandwalle JL, Rochette J, Borot N, Coppin H, Roth MP, Ryan E, Corwe J, Totaro A, Gasparini P, Roetto A, Camaschella C, Darke C, Wallace DF, Saeb-Parsy K, Dooley JS, Worwood M, Walker AP. Polymorphism in intron 4 of HFE does not compromise haemochromatosis mutation results. The European Haemochromatosis Consortium. Nat Genet 1999, 23: 271-272.
  29. Borot N, Roth MP, Malfroy L, Demangel C, Vinel JP, Pascal JP, Coppin H. Mutations in the MHC class I-like candidate gene for hemochromatosis in French patients. Immunogenetics 1997, 45, 320-324.
  30.  Malfroy L, Roth MP, Carrington M, Borot N, Volz A, Ziegler A, Coppin H. Heterogeneity in rates of recombination in the 6-Mb region telomeric to the human major histocompatibility complex. Genomics 1997, 43, 226-231.
  31.  Roth MP, Giraldo P, Hariti G, Poloni ES, Sanchez-Mazas A, Stefano GFD, Dugoujon JM, Coppin H. Absence of the hemochromatosis gene Cys282Tyr mutation in three ethnic groups from Algeria (Mzab), Ethiopia, and Senegal. Immunogenetics 1997, 46, 222-225.
  32.  Totaro A, Grifa A, Carella M, D'ambrosio L, Valentino M, Roth MP, Borot N, Coppin H, Roetto A, Camaschella C, Gasparini P. Hereditary hemochromatosis: a HpaI polymorphism within the HLA-H gene. Mol Cell Probes 1997, 11, 229-230.

To see more: 
http://www.ncbi.nlm.nih.gov/pubmed/?term=(coppin+h)+AND+(iron+OR+hemochromatosis)
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