Jean-Philippe Nougayrède |
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EQUIPE 2 : PATHOGÉNIE ET COMMENSALISME DES ENTEROBACTÉRIES
TEAM 2 : PATHOGENESIS AND COMMENSALISM OF ENTEROBACTERIA |
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Mini CV
- 2000 PhD of Microbiology, Lyon University
- 2000-2003 Post-doc, Baltimore, MD, USA
- 2003-2006 Post-doc, INRA, Toulouse
- 2006 Junior permanent researcher (CR2)
- 2010 Senior permanent researcher (CR1)
- 2021 Research director (DR2)
Recherche/projet research/project
Mode of action of bacterial toxins
Mode d'action des toxines bactériennes
Mode d'action des toxines bactériennes
Production scientifique scientific production
Bossuet N , Guyonnet C, Chagneau CV, Tang-Fichaux M, Penary M, Loubet D, Branchu P, Oswald E, Nougayrede JP. Oxygen concentration modulates colibactin production. Gut Microbes. 2023. 15(1):2222437.
Chagneau CV, Payros D, Tang-Fichaux M, Auvray F, Nougayrède JP, Oswald E. The pks island: a bacterial Swiss army knife? Colibactin: beyond DNA damage and cancer. Trends Microbiol. 2022. 30(12):1146-1159.
Auvray F, Perrat A, Arimizu Y, Chagneau CV, Bossuet-Greif N, Massip C, Brugère H, Nougayrède JP, Hayashi T, Branchu P, Ogura Y, Oswald E. Insights into the acquisition of the pks island and production of colibactin in the Escherichia coli population. Microb Genom. 2021. May;7(5).
Chagneau CV, Massip C, Bossuet-Greif N, Fremez C, Motta JP, Shima A, Besson C, Le Faouder P, Cénac N, Roth MP, Coppin H, Fontanié M, Martin P, Nougayrède JP, Oswald E. Uropathogenic E. coli induces DNA damage in the bladder. PLoS Pathog. 2021. 17(2):e1009310.
Tang-Fichaux M, Chagneau CV, Bossuet-Greif N, Nougayrède JP, Oswald É, Branchu P. The Polyphosphate Kinase of Escherichia coli Is Required for Full Production of the Genotoxin Colibactin. mSphere. 2020 5(6):e01195-20.
Wallenstein A, Rehm N, Brinkmann M, Selle M, Bossuet-Greif N, Sauer D, Bunk B, Spröer C, Wami HT, Homburg S, von Bünau R, König S, Nougayrède JP, Overmann J, Oswald E, Müller R, Dobrindt U. ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli. mSphere. 2020. 5(4):e00591-20
Chagneau CV, Garcie C, Bossuet-Greif N, Tronnet S, Brachmann AO, Piel J, Nougayrède JP, Martin P, Oswald E. The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin. mSphere. 2019 4(5):e00414-19.
Massip C, Branchu P, Bossuet-Greif N, Chagneau CV, Gaillard D, Martin P, Boury M, Sécher T, Dubois D, Nougayrède JP, Oswald E. Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917. PLoS Pathog. 2019 15(9):e1008029.
Bossuet-Greif N, Vignard J, Taieb F, Mirey G, Dubois D, Petit C, Oswald E, Nougayrède JP. The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells. mBio. 2018 9(2). pii: e02393-17.
Garcie C., Tronnet S., Garénaux A., McCarthy A.J., Brachmann A.O., Pénary M, Houle S., Nougayrède J.P., Piel J., Taylor P.W., Dozois C.M., Genevaux P., Oswald E. and Martin P. The stress-responsive Hsp90 chaperone is required for the production of genotoxin and siderophore by pathogenic Escherichia coli. J Infect Dis. 2016 214(6):916-24.
Taieb F, Petit C, Nougayrède JP, Oswald E. The Enterobacterial Genotoxins: Cytolethal Distending Toxin and Colibactin. EcoSal Plus. 2016. 7(1).
Bossuet-Greif N, Dubois D, Petit C, Tronnet S, Martin P, Bonnet R, Oswald E, Nougayrède JP. Escherichia coli ClbS is a colibactin resistance protein. Mol Microbiol. 2016. 99(5):897-908.
Murase K, Martin P, Porcheron G, Houle S, Helloin E, Penary M, Nougayrede JP, Dozois CM, Hayashi T, Oswald E. HlyF Produced by Extraintestinal Pathogenic Escherichia coli Is a Virulence Factor That Regulates Outer Membrane Vesicle Biogenesis. J Infect Dis. 2016. 213(5):856-65.
Chagneau CV, Payros D, Tang-Fichaux M, Auvray F, Nougayrède JP, Oswald E. The pks island: a bacterial Swiss army knife? Colibactin: beyond DNA damage and cancer. Trends Microbiol. 2022. 30(12):1146-1159.
Auvray F, Perrat A, Arimizu Y, Chagneau CV, Bossuet-Greif N, Massip C, Brugère H, Nougayrède JP, Hayashi T, Branchu P, Ogura Y, Oswald E. Insights into the acquisition of the pks island and production of colibactin in the Escherichia coli population. Microb Genom. 2021. May;7(5).
Chagneau CV, Massip C, Bossuet-Greif N, Fremez C, Motta JP, Shima A, Besson C, Le Faouder P, Cénac N, Roth MP, Coppin H, Fontanié M, Martin P, Nougayrède JP, Oswald E. Uropathogenic E. coli induces DNA damage in the bladder. PLoS Pathog. 2021. 17(2):e1009310.
Tang-Fichaux M, Chagneau CV, Bossuet-Greif N, Nougayrède JP, Oswald É, Branchu P. The Polyphosphate Kinase of Escherichia coli Is Required for Full Production of the Genotoxin Colibactin. mSphere. 2020 5(6):e01195-20.
Wallenstein A, Rehm N, Brinkmann M, Selle M, Bossuet-Greif N, Sauer D, Bunk B, Spröer C, Wami HT, Homburg S, von Bünau R, König S, Nougayrède JP, Overmann J, Oswald E, Müller R, Dobrindt U. ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli. mSphere. 2020. 5(4):e00591-20
Chagneau CV, Garcie C, Bossuet-Greif N, Tronnet S, Brachmann AO, Piel J, Nougayrède JP, Martin P, Oswald E. The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin. mSphere. 2019 4(5):e00414-19.
Massip C, Branchu P, Bossuet-Greif N, Chagneau CV, Gaillard D, Martin P, Boury M, Sécher T, Dubois D, Nougayrède JP, Oswald E. Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917. PLoS Pathog. 2019 15(9):e1008029.
Bossuet-Greif N, Vignard J, Taieb F, Mirey G, Dubois D, Petit C, Oswald E, Nougayrède JP. The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells. mBio. 2018 9(2). pii: e02393-17.
Garcie C., Tronnet S., Garénaux A., McCarthy A.J., Brachmann A.O., Pénary M, Houle S., Nougayrède J.P., Piel J., Taylor P.W., Dozois C.M., Genevaux P., Oswald E. and Martin P. The stress-responsive Hsp90 chaperone is required for the production of genotoxin and siderophore by pathogenic Escherichia coli. J Infect Dis. 2016 214(6):916-24.
Taieb F, Petit C, Nougayrède JP, Oswald E. The Enterobacterial Genotoxins: Cytolethal Distending Toxin and Colibactin. EcoSal Plus. 2016. 7(1).
Bossuet-Greif N, Dubois D, Petit C, Tronnet S, Martin P, Bonnet R, Oswald E, Nougayrède JP. Escherichia coli ClbS is a colibactin resistance protein. Mol Microbiol. 2016. 99(5):897-908.
Murase K, Martin P, Porcheron G, Houle S, Helloin E, Penary M, Nougayrede JP, Dozois CM, Hayashi T, Oswald E. HlyF Produced by Extraintestinal Pathogenic Escherichia coli Is a Virulence Factor That Regulates Outer Membrane Vesicle Biogenesis. J Infect Dis. 2016. 213(5):856-65.
