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EQUIPE 2 : PATHOGÉNIE ET COMMENSALISME DES ENTEROBACTÉRIES
TEAM 2 : PATHOGENESIS AND COMMENSALISM OF ENTEROBACTERIA |
MINI CV
• depuis 2023: IRSD
• 2008 - 2022 Chargée de recherche INRAE, Département TRANSFORM
Toulouse Biotechnology Institute (TBI, UMR792)
Pôle Biocatalyse - Equipe Catalyse et Ingénierie Moléculaire Enzymatiques
Biotransformation des lipides et des polymères
Recyclage biologique du plastique
Co-Responsable du laboratoire coopératif PoPLaB (Polymers, Plastics and Biotechnology) entre Carbios et TBI
• 2006 - 2008 Attachée Temporaire d’Enseignement et de Recherche Université d’Evry/Genoscope
Laboratoire de Génomique Métabolique (UMR 8030)
Identification et caractérisation de voies métaboliques nouvelles chez Acinetobacter baylyi
• 2003-2006 Doctorat
Laboratoire de Chimie et Biochimie des Substances Naturelles (UMR 5154 Muséum d’Histoire Naturelle de Paris
Etude de la voie de maturation et du mécanisme d´import de la microcine J25, peptide antimicrobien inhibiteur de l´ARN polymérase.
• since 2023:IRSD
• 2008 - 2022 INRAE Research Fellow, TRANSFORM Department
Toulouse Biotechnology Institute (TBI, UMR792)
Biocatalysis Pole - Catalysis and Enzyme Molecular Engineering
Biotransformation of lipids and polymers
Co-Head of the PoPLaB (Polymers, Plastics and Biotechnology) cooperative laboratory between Carbios and TBI
• 2006 - 2008 Temporary Teaching and Research assistant
Metabolic Genomics Laboratory (UMR 8030; University of Evry/Genoscope)
Identification and characterization of new metabolic pathways in Acinetobacter baylyi
• 2003-2006 PhD Laboratory of Chemistry and Biochemistry of Natural Substances (UMR 5154; National Museum of Natural History, Paris)
Study of the maturation pathway and import mechanism of microcin J25, an antimicrobial peptide that inhibits RNA polymerase.
• 2008 - 2022 Chargée de recherche INRAE, Département TRANSFORM
Toulouse Biotechnology Institute (TBI, UMR792)
Pôle Biocatalyse - Equipe Catalyse et Ingénierie Moléculaire Enzymatiques
Biotransformation des lipides et des polymères
Recyclage biologique du plastique
Co-Responsable du laboratoire coopératif PoPLaB (Polymers, Plastics and Biotechnology) entre Carbios et TBI
• 2006 - 2008 Attachée Temporaire d’Enseignement et de Recherche Université d’Evry/Genoscope
Laboratoire de Génomique Métabolique (UMR 8030)
Identification et caractérisation de voies métaboliques nouvelles chez Acinetobacter baylyi
• 2003-2006 Doctorat
Laboratoire de Chimie et Biochimie des Substances Naturelles (UMR 5154 Muséum d’Histoire Naturelle de Paris
Etude de la voie de maturation et du mécanisme d´import de la microcine J25, peptide antimicrobien inhibiteur de l´ARN polymérase.
• since 2023:IRSD
• 2008 - 2022 INRAE Research Fellow, TRANSFORM Department
Toulouse Biotechnology Institute (TBI, UMR792)
Biocatalysis Pole - Catalysis and Enzyme Molecular Engineering
Biotransformation of lipids and polymers
Co-Head of the PoPLaB (Polymers, Plastics and Biotechnology) cooperative laboratory between Carbios and TBI
• 2006 - 2008 Temporary Teaching and Research assistant
Metabolic Genomics Laboratory (UMR 8030; University of Evry/Genoscope)
Identification and characterization of new metabolic pathways in Acinetobacter baylyi
• 2003-2006 PhD Laboratory of Chemistry and Biochemistry of Natural Substances (UMR 5154; National Museum of Natural History, Paris)
Study of the maturation pathway and import mechanism of microcin J25, an antimicrobial peptide that inhibits RNA polymerase.
Projets de recherche / research projects :
TOXINES ET CANCERS
TOXINS AND CANCERS
TOXINS AND CANCERS
production scientifique / scientific production
Enzymes' Power for Plastics Degradation.
Tournier V, Duquesne S, Guillamot F, Cramail H, Taton D, Marty A, André I. Chem Rev. 2023 May 10;123(9):5612-5701. doi: 10.1021/acs.chemrev.2c00644.
Characterization of a novel β-alanine biosynthetic pathway consisting of promiscuous metabolic enzymes.
Perchat N, Dubois C, Mor-Gautier R, Duquesne S, Lechaplais C, Roche D, Fouteau S, Darii E, Perret A. J Biol Chem. 2022 Jul;298(7):102067. doi: 10.1016/j.jbc.2022.102067.
An NMR look at an engineered PET depolymerase.
Charlier C, Gavalda S, Borsenberger V, Duquesne S, Marty A, Tournier V, Lippens G. Biophys J. 2022 Aug 2;121(15):2882-2894. doi: 10.1016/j.bpj.2022.07.002.
An engineered PET depolymerase to break down and recycle plastic bottles.
Tournier V, Topham CM, Gilles A, David B, Folgoas C, Moya-Leclair E, Kamionka E, Desrousseaux ML, Texier H, Gavalda S, Cot M, Guémard E, Dalibey M, Nomme J, Cioci G, Barbe S, Chateau M, André I, Duquesne S, Marty A. Nature. 2020 Apr;580(7802):216-219. doi: 10.1038/s41586-020-2149-4.
Conferring cellulose-degrading ability to Yarrowia lipolytica to facilitate a consolidated bioprocessing approach.
Guo ZP, Duquesne S, Bozonnet S, Cioci G, Nicaud JM, Marty A, O'Donohue MJ. Biotechnol Biofuels. 2017 May 19;10:132. doi: 10.1186/s13068-017-0819-8.
Metagenomics for the discovery of pollutant degrading enzymes.
Ufarté L, Laville É, Duquesne S, Potocki-Veronese G. Biotechnol Adv. 2015 Dec;33(8):1845-54. doi: 10.1016/j.biotechadv.2015.10.009.
Construction of a highly active xylanase displaying oleaginous yeast: comparison of anchoring systems.
Duquesne S, Bozonnet S, Bordes F, Dumon C, Nicaud JM, Marty A. PLoS One. 2014 Apr 17;9(4):e95128. doi: 10.1371/journal.pone.0095128.
Enantioselectivity of Candida rugosa lipases (Lip1, Lip3, and Lip4) towards 2-bromo phenylacetic acid octyl esters controlled by a single amino acid.
Piamtongkam R, Duquesne S, Bordes F, Barbe S, André I, Marty A, Chulalaksananukul W. Biotechnol Bioeng. 2011 Aug;108(8):1749-56. doi: 10.1002/bit.23124.
Microcins, gene-encoded antibacterial peptides from enterobacteria.
Duquesne S, Destoumieux-Garzón D, Peduzzi J, Rebuffat S. Nat Prod Rep. 2007 Aug;24(4):708-34. doi: 10.1039/b516237h.
Two enzymes catalyze the maturation of a lasso peptide in Escherichia coli.
Duquesne S, Destoumieux-Garzón D, Zirah S, Goulard C, Peduzzi J, Rebuffat S. Chem Biol. 2007 Jul;14(7):793-803. doi: 10.1016/j.chembiol.2007.06.004.
Desrousseaux ML., Texier H., Duquesne S., Marty A., Alaoui Dalibey M., Château M.
A process for degrading plastic products,
Brevet WO2017198786
Tournier V., Texier H., Desrousseaux M.-L., Topham C., Barbe S., André I., Duquesne S., Marty A.
Novel esterases and uses thereof.
Brevet WO2018011281
Guicherd M., Vuillemin M., Benkhaled M., Duquesne S., Marty A.
Improved plastic degrading proteases.
Brevet WO2018/109183 A1
Alvarez P., Amillastre E. Duquesne S., Marty A.
Polypeptide présentant une activité de dégradation de polyester et utilisations de celui-ci
Brevet WO/2016/062695
Tournier V, Duquesne S, Guillamot F, Cramail H, Taton D, Marty A, André I. Chem Rev. 2023 May 10;123(9):5612-5701. doi: 10.1021/acs.chemrev.2c00644.
Characterization of a novel β-alanine biosynthetic pathway consisting of promiscuous metabolic enzymes.
Perchat N, Dubois C, Mor-Gautier R, Duquesne S, Lechaplais C, Roche D, Fouteau S, Darii E, Perret A. J Biol Chem. 2022 Jul;298(7):102067. doi: 10.1016/j.jbc.2022.102067.
An NMR look at an engineered PET depolymerase.
Charlier C, Gavalda S, Borsenberger V, Duquesne S, Marty A, Tournier V, Lippens G. Biophys J. 2022 Aug 2;121(15):2882-2894. doi: 10.1016/j.bpj.2022.07.002.
An engineered PET depolymerase to break down and recycle plastic bottles.
Tournier V, Topham CM, Gilles A, David B, Folgoas C, Moya-Leclair E, Kamionka E, Desrousseaux ML, Texier H, Gavalda S, Cot M, Guémard E, Dalibey M, Nomme J, Cioci G, Barbe S, Chateau M, André I, Duquesne S, Marty A. Nature. 2020 Apr;580(7802):216-219. doi: 10.1038/s41586-020-2149-4.
Conferring cellulose-degrading ability to Yarrowia lipolytica to facilitate a consolidated bioprocessing approach.
Guo ZP, Duquesne S, Bozonnet S, Cioci G, Nicaud JM, Marty A, O'Donohue MJ. Biotechnol Biofuels. 2017 May 19;10:132. doi: 10.1186/s13068-017-0819-8.
Metagenomics for the discovery of pollutant degrading enzymes.
Ufarté L, Laville É, Duquesne S, Potocki-Veronese G. Biotechnol Adv. 2015 Dec;33(8):1845-54. doi: 10.1016/j.biotechadv.2015.10.009.
Construction of a highly active xylanase displaying oleaginous yeast: comparison of anchoring systems.
Duquesne S, Bozonnet S, Bordes F, Dumon C, Nicaud JM, Marty A. PLoS One. 2014 Apr 17;9(4):e95128. doi: 10.1371/journal.pone.0095128.
Enantioselectivity of Candida rugosa lipases (Lip1, Lip3, and Lip4) towards 2-bromo phenylacetic acid octyl esters controlled by a single amino acid.
Piamtongkam R, Duquesne S, Bordes F, Barbe S, André I, Marty A, Chulalaksananukul W. Biotechnol Bioeng. 2011 Aug;108(8):1749-56. doi: 10.1002/bit.23124.
Microcins, gene-encoded antibacterial peptides from enterobacteria.
Duquesne S, Destoumieux-Garzón D, Peduzzi J, Rebuffat S. Nat Prod Rep. 2007 Aug;24(4):708-34. doi: 10.1039/b516237h.
Two enzymes catalyze the maturation of a lasso peptide in Escherichia coli.
Duquesne S, Destoumieux-Garzón D, Zirah S, Goulard C, Peduzzi J, Rebuffat S. Chem Biol. 2007 Jul;14(7):793-803. doi: 10.1016/j.chembiol.2007.06.004.
Desrousseaux ML., Texier H., Duquesne S., Marty A., Alaoui Dalibey M., Château M.
A process for degrading plastic products,
Brevet WO2017198786
Tournier V., Texier H., Desrousseaux M.-L., Topham C., Barbe S., André I., Duquesne S., Marty A.
Novel esterases and uses thereof.
Brevet WO2018011281
Guicherd M., Vuillemin M., Benkhaled M., Duquesne S., Marty A.
Improved plastic degrading proteases.
Brevet WO2018/109183 A1
Alvarez P., Amillastre E. Duquesne S., Marty A.
Polypeptide présentant une activité de dégradation de polyester et utilisations de celui-ci
Brevet WO/2016/062695
