Rigosertib promotes expression of the antimicrobial peptide beta-defensin-3 in human cells. Weronika Wozniak, David Sagnat, ..., Étienne Buscail, ..., Nathalie Vergnolle, et al., Scientific Reports 2026. DOI: 10.1038/s41598-026-79053-5

Accelerated Epigenetic and Inflammatory Aging and Intrinsic Capacity. Laure Rouch, Philipe de Souto Barreto, ..., Nathalie Vergnolle, Jean‐Paul Motta, ..., Pauline Floch, Céline Deraison, Chrystelle Bonnart, et al., JAMA Network Open 2026. DOI: 10.1001/jamanetworkopen.2026.24102

L26/O-068 Tubal extracellular vesicles from human fallopian tubes and derived organoids promote the maintenance of sperm fertilising capacity. E. Bruno, David Sagnat, ..., Nathalie Vergnolle, et al., Human Reproduction 2026. DOI: 10.1093/humrep/deag083.068

High thrombin activity associated with crohn’s disease induces microbiota pathogenicity contributing to mucosal inflammation. Guillaume Le Cosquer, Melissa Pannier, ..., Laura Guiraud, ..., Perrine Rousset, ..., Étienne Buscail, ..., Céline Deraison, Nathalie Vergnolle, Jean‐Paul Motta, Gut Microbes 2026. DOI: 10.1080/19490976.2026.2687903

The role of dietary patterns on epigenetic and inflammatory aging based on the INSPIRE-T study. Natasha Aparecida Grande de França, Yves Rolland, ..., Nathalie Vergnolle, Jean‐Paul Motta, ..., Pauline Floch, Céline Deraison, Chrystelle Bonnart, et al., Communications Medicine 2026. DOI: 10.1038/s43856-026-01643-1

Bidirectional associations between biological aging, cardiovascular health, and cardiovascular risk: findings from the INSPIRE-T lifespan cohort. Mathilde Strumia, Vanina Bongard, ..., Nathalie Vergnolle, Jean‐Paul Motta, ..., Pauline Floch, Céline Deraison, Chrystelle Bonnart, et al., GeroScience 2026. DOI: 10.1007/s11357-026-02251-6

Long‐Term Effects of Xenotransplantation of Human Enteric Glia in an Immunocompetent Rat Model of Acute Brain Injury. Nina Colitti, Edwige Rice, ..., Étienne Buscail, ..., Nathalie Vergnolle, et al., Advanced Science 2026. DOI: 10.1002/advs.202503362

Evaluation of the prebiotic potential of polyphenol-rich plant extracts in a mouse model of colitis. Damien Guillemet, Perrine Rousset, ..., Anissa Edir, ..., Laura Guiraud, Nathalie Vergnolle, Jean‐Paul Motta, Microbiota and Host 2025. DOI: 10.1530/mah-25-0007

Oral indomethacin modifies small intestine biofilms and host-microbe interaction mediators. Arezoo Haghighi, András S. Tóth, ..., Jean‐Paul Motta, Nathalie Vergnolle, et al., Life Sciences 2025. DOI: 10.1016/j.lfs.2025.124114

Modeling Postoperative Pathologic Ileus in Mice: A Simplified and Translational Approach. Romain Gauthier, Julie Thevenin, ..., Perrine Rousset, ..., Astrid Canivet, ..., Nathalie Vergnolle, Étienne Buscail, Céline Deraison, Neurogastroenterology & Motility 2025. DOI: 10.1111/nmo.70157

Bispecific nanobody® as a new pharmacological drug for the selective inhibition of Trypsin‐3. Mélissa David, Anaïs Faihy, ..., Anissa Edir, Astrid Canivet, ..., Nathalie Vergnolle, ..., Céline Deraison, British Journal of Pharmacology 2025. DOI: 10.1111/bph.70100

Pathogenicity of commensal gut biofilm in prefrail aging. Guillaume Le Cosquer, Melissa Pannier, ..., Céline Deraison, Nathalie Vergnolle, Jean‐Paul Motta, et al., npj Biofilms and Microbiomes 2025. DOI: 10.1038/s41522-025-00716-8

The associations between biological markers of aging and appetite loss across adulthood: retrospective case–control data from the INSPIRE-T study. Annelie Turesson, Afsaneh Koochek, ..., Nathalie Vergnolle, Jean‐Paul Motta, ..., Céline Deraison, et al., GeroScience 2025. DOI: 10.1007/s11357-025-01691-w

Human fallopian tube organoids provide a favourable environment for sperm motility. Nicolas Gatimel, Guillaume Perez, ..., David Sagnat, ..., Céline Deraison, Jean‐Paul Motta, ..., Nathalie Vergnolle, Human Reproduction 2025. DOI: 10.1093/humrep/deae258

Human colonic organoids for understanding early events of familial adenomatous polyposis pathogenesis. Nolwenn Laborde, Alexandre Barusseaud, ..., Anne Laure Breton, Nathalie Vergnolle, ..., Frédérick Barreau, Claire Racaud‐Sultan, Emmanuel Mas, The Journal of Pathology 2024. DOI: 10.1002/path.6366

TRPV4 stimulates colonic afferents through mucosal release of ATP and glutamate. Michelle Y. Meng, Luke W Paine, David Sagnat, ..., Étienne Buscail, ..., Nathalie Vergnolle, et al., British Journal of Pharmacology 2024. DOI: 10.1111/bph.17408

Proteolytic bacteria expansion during colitis amplifies inflammation through cleavage of the external domain of PAR2. Liam Emile Rondeau, B Barbosa da Luz, ..., Céline Deraison, ..., Nathalie Vergnolle, et al., Gut Microbes 2024. DOI: 10.1080/19490976.2024.2387857

Intestinal organoids to model Salmonella infection and its impact on progenitors. Yan Jin, Claire Racaud‐Sultan, ..., Anissa Edir, ..., Nathalie Vergnolle, Agnès Wiedemann, Scientific Reports 2024. DOI: 10.1038/s41598-024-65485-4

Chymotrypsin activity signals to intestinal epithelium by protease‐activated receptor‐dependent mechanisms. Simon Guignard, Mahmoud Saifeddine, ..., Laura Guiraud, David Sagnat, ..., Anissa Edir, ..., Étienne Buscail, ..., Nathalie Vergnolle, ..., Céline Deraison, Chrystelle Bonnart, British Journal of Pharmacology 2024. DOI: 10.1111/bph.16341

Involvement of CATSPER 2 mutation in a familial context of unexplained infertility and fertilization failure associated with hearing loss: a case report. Simon Guignard, Christina Guillaume, ..., Nathalie Vergnolle, Céline Deraison, Chrystelle Bonnart, et al., F&S Reports 2023. DOI: 10.1016/j.xfre.2023.12.003

S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis. Liwen Deng, Flavia G. Costa, ..., Céline Deraison, ..., Nathalie Vergnolle, et al., Cell 2023. DOI: 10.1016/j.cell.2023.10.019

Postoperative ileus after digestive surgery: Network meta‐analysis of pharmacological intervention. Étienne Buscail, Thibault Planchamp, ..., Jean‐Paul Motta, Nathalie Vergnolle, Céline Deraison, et al., British Journal of Clinical Pharmacology 2023. DOI: 10.1111/bcp.15878

40 PERIPHERAL MEDIATORS INVOLVED IN SENSORY NEURONS SENSITIZATION IN IBD PATIENTS IN REMISSION: A WINDOW ON A PAR1-MEDIATED MECHANISM OF IBD-ASSOCIATED PAIN. Corinne Rolland, Perrine Rousset, ..., Étienne Buscail, ..., Céline Deraison, Nathalie Vergnolle, Gastroenterology 2023. DOI: 10.1016/s0016-5085(23)00987-3

Elafin and its precursor trappin‐2: What is their therapeutic potential for intestinal diseases?. Céline Deraison, Chrystelle Bonnart, ..., Nathalie Vergnolle, British Journal of Pharmacology 2022. DOI: 10.1111/bph.15985

Prenatal stress induces changes in PAR2- and M3-dependent regulation of colon primitive cells. Mathieu Berger, Laura Guiraud, ..., David Sagnat, ..., Nathalie Vergnolle, Céline Deraison, ..., Claire Racaud‐Sultan, American Journal of Physiology-Gastrointestinal and Liver Physiology 2022. DOI: 10.1152/ajpgi.00061.2022

Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation. Jean‐Paul Motta, Corinne Rolland, Anissa Edir, ..., David Sagnat, Chrystelle Bonnart, Perrine Rousset, Laura Guiraud, ..., Emmanuel Mas, ..., Étienne Buscail, ..., Nathalie Vergnolle, Céline Deraison, Mucosal Immunology 2021. DOI: 10.1038/s41385-021-00375-w

Colitis Linked to Endoplasmic Reticulum Stress Induces Trypsin Activity Affecting Epithelial Functions. Núria Solà Tapias, Alexandre Denadai‐Souza, ..., Anissa Edir, ..., Emmanuel Mas, ..., Céline Deraison, Chrystelle Bonnart, Nathalie Vergnolle, Frédérick Barreau, Journal of Crohn's and Colitis 2021. DOI: 10.1093/ecco-jcc/jjab035

GSK3β, a Master Kinase in the Regulation of Adult Stem Cell Behavior. Claire Racaud‐Sultan, Nathalie Vergnolle, Cells 2021. DOI: 10.3390/cells10020225

Increased Mucosal Thrombin is Associated with Crohn’s Disease and Causes Inflammatory Damage through Protease-activated Receptors Activation. Jean‐Paul Motta, Simone Palese, ..., Perrine Rousset, David Sagnat, Laura Guiraud, Anissa Edir, Carine Séguy, ..., Éric Oswald, ..., Céline Deraison, Nathalie Vergnolle, Journal of Crohn's and Colitis 2020. DOI: 10.1093/ecco-jcc/jjaa229

Characterization of Human Colon Organoids From Inflammatory Bowel Disease Patients. Emilie d'Aldebert, Muriel Quaranta, ..., Claire Racaud‐Sultan, Emmanuel Mas, Céline Deraison, Nathalie Vergnolle, Frontiers in Cell and Developmental Biology 2020. DOI: 10.3389/fcell.2020.00363

The Interplay Between Genetic Risk Factors and Proteolytic Dysregulation in the Pathophysiology of Inflammatory Bowel Disease. Núria Solà-Tapias, Nathalie Vergnolle, ..., Frédérick Barreau, Journal of Crohn's and Colitis 2020. DOI: 10.1093/ecco-jcc/jjaa033

Sexual dimorphism in PAR2-dependent regulation of primitive colonic cells. Julie Noguerol, Pierre-Jean Roustan, ..., Laura Guiraud, David Sagnat, Anissa Edir, Chrystelle Bonnart, ..., Céline Deraison, Nathalie Vergnolle, Claire Racaud‐Sultan, Biology of Sex Differences 2019. DOI: 10.1186/s13293-019-0262-6

Active thrombin produced by the intestinal epithelium controls mucosal biofilms. Jean‐Paul Motta, Alexandre Denadai‐Souza, David Sagnat, Laura Guiraud, Anissa Edir, Chrystelle Bonnart, ..., Perrine Rousset, ..., Carine Séguy, ..., Éric Oswald, ..., Céline Deraison, Nathalie Vergnolle, Nature Communications 2019. DOI: 10.1038/s41467-019-11140-w

Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2. Alberto Caminero, Justin L. McCarville, ..., Céline Deraison, ..., Nathalie Vergnolle, et al., Nature Communications 2019. DOI: 10.1038/s41467-019-09037-9

Protectin D1 n-3 DPA and resolvin D5 n-3 DPA are effectors of intestinal protection. Thomas Gobbetti, Jesmond Dalli, ..., Nathalie Vergnolle, Céline Deraison, et al., Proceedings of the National Academy of Sciences 2017. DOI: 10.1073/pnas.1617290114

Epithelial expression and function of trypsin-3 in irritable bowel syndrome. Claire Rolland-Fourcade, Alexandre Denadai‐Souza, ..., Jean‐Paul Motta, ..., Céline Deraison, Nathalie Vergnolle, Gut 2017. DOI: 10.1136/gutjnl-2016-312094

Endogenous analgesia mediated by CD4+ T lymphocytes is dependent on enkephalins in mice. Lilian Basso, Jérôme Boué, ..., Nathalie Vergnolle, Céline Deraison, et al., Journal of Neuroinflammation 2016. DOI: 10.1186/s12974-016-0591-x

Apelin targets gut contraction to control glucose metabolism via the brain. Audren Fournel, Anne Drougard, ..., Perrine Rousset, ..., Nathalie Vergnolle, et al., Gut 2015. DOI: 10.1136/gutjnl-2015-310230