Digestive Models Platform

    Perrine Rousset

    Digestive Models IRSD
    Contact

    General Mission

    Despite the development of alternative methods, the use of animal models remains essential for the research themes of the IRSD teams. This platform aims to provide the most relevant in vivo digestive models to IRSD teams as well as to the broader academic and private scientific community.

    It facilitates the referencing and sharing of animal models already used by various teams and also seeks to identify researchers’ needs and develop new models. Experiments are conducted in compliance with animal ethics and regulatory requirements, in accordance with the European directive.

    Models

    • Colitis
      • Acute and chronic DSS
      • Acute and chronic TNBS
    • Transit
      • Constipation
      • Diarrhea
    • Visceral Pain
      • Mustard oil

    Techniques

    • Evaluation of visceral hypersensitivity: Measurement of intracolic pressure
    • IVIS monitoring (preclinical imaging)

    Services

    • Project execution: protocol design, experimentation, and result analysis
    • Training of personnel in experimental models
    • Development of new models

    Staff

    Perrine Rousset
    Manager

    Publications

    High thrombin activity associated with crohn’s disease induces microbiota pathogenicity contributing to mucosal inflammation. Guillaume Le Cosquer, Melissa Pannier, ..., Laura Guiraud, ..., Perrine Rousset, ..., Étienne Buscail, ..., Céline Deraison, Nathalie Vergnolle, Jean‐Paul Motta, Gut Microbes 2026. DOI: 10.1080/19490976.2026.2687903

    Modeling Postoperative Pathologic Ileus in Mice: A Simplified and Translational Approach. Romain Gauthier, Julie Thevenin, ..., Perrine Rousset, ..., Astrid Canivet, ..., Nathalie Vergnolle, Étienne Buscail, Céline Deraison, Neurogastroenterology & Motility 2025. DOI: 10.1111/nmo.70157

    Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation. Jean‐Paul Motta, Corinne Rolland, Anissa Edir, ..., David Sagnat, Chrystelle Bonnart, Perrine Rousset, Laura Guiraud, ..., Emmanuel Mas, ..., Étienne Buscail, ..., Nathalie Vergnolle, Céline Deraison, Mucosal Immunology 2021. DOI: 10.1038/s41385-021-00375-w

    Increased Mucosal Thrombin is Associated with Crohn’s Disease and Causes Inflammatory Damage through Protease-activated Receptors Activation. Jean‐Paul Motta, Simone Palese, ..., Perrine Rousset, David Sagnat, Laura Guiraud, Anissa Edir, Carine Séguy, ..., Éric Oswald, ..., Céline Deraison, Nathalie Vergnolle, Journal of Crohn's and Colitis 2020. DOI: 10.1093/ecco-jcc/jjaa229

    Active thrombin produced by the intestinal epithelium controls mucosal biofilms. Jean‐Paul Motta, Alexandre Denadai‐Souza, David Sagnat, Laura Guiraud, Anissa Edir, Chrystelle Bonnart, ..., Perrine Rousset, ..., Carine Séguy, ..., Éric Oswald, ..., Céline Deraison, Nathalie Vergnolle, Nature Communications 2019. DOI: 10.1038/s41467-019-11140-w

    Apelin targets gut contraction to control glucose metabolism via the brain. Audren Fournel, Anne Drougard, ..., Perrine Rousset, ..., Nathalie Vergnolle, et al., Gut 2015. DOI: 10.1136/gutjnl-2015-310230