Pathogénie et commensalisme des entérobactéries

Équipe 2

    Keywords: Commensalisme et pathogénie bactériennes, Microbiote intestinal​

    Programme de recherche

    ​L’équipe « Pathogenèse et Commensalisme des Entérobactéries », dirigée par Eric Oswald, développe une approche multidisciplinaire (microbiologie, biologie moléculaire et cellulaire, immunologie, métagénomique, physiologie intégrée, ainsi que des modèles animaux) pour étudier la frontière entre commensalisme et pathogénie bactériennes et leur rôle dans la modulation du cycle cellulaire et de l’intégrité génomique de la cellule hôte, la physiologie ou encore le métabolisme. Afin d’atteindre ces objectifs, de nouvelles connaissances scientifiques et technologiques ont été acquises dans les différents aspects de l’infection bactérienne, de la colonisation intestinale et de l’écologie. L’équipe travaille sur plusieurs pathovars de Escherichia coli tels que les E. coli entéropathogènes et hémorragiques ou pathogènes extra-intestinaux (EPEC et EHEC ou ExPEC), mais aussi sur les E. coli commensaux et probiotiques ainsi que sur le microbiote intestinal, la dysbiose et son impact sur l’infection, les maladies métaboliques et la carcinogenèse. Plusieurs axes de recherche sont développés:

    1. Toxines et cancers
    2. Du commensalisme à la pathogénicicité
    3. Bactéries pathogènes et résistance aux antibiotiques
    4. Dysbioses à Escherichia coli et maladies métaboliques

    Membres

    Toxines et cancer

    Du commensalisme à la pathogénicité

    Bactéries pathogènes et résistance aux antibiotiques

    Publications

    Comment un mécanisme de résistance aux antibiotiques favorise la virulence bactérienne. Audrey Goman, Lola Manenc, ..., Priscilla Branchu, et al., médecine/sciences 2026. DOI: 10.1051/medsci/2025252

    Outer Membrane Vesicles as a Versatile Platform for Vaccine Development: Engineering Strategies, Applications and Challenges. Asja Garling, Frédéric Auvray, ..., Éric Oswald, Priscilla Branchu, Journal of Extracellular Vesicles 2025. DOI: 10.1002/jev2.70150

    Zoonotic potential of uropathogenic Escherichia coli lineages from companion animals. Nicolas Jousserand, Frédéric Auvray, ..., Éric Oswald, Veterinary Research 2025. DOI: 10.1186/s13567-025-01493-0

    Uncovering a new family of conserved virulence factors that promote the production of host‐damaging outer membrane vesicles in Gram‐negative bacteria. Audrey Goman, Bérengère Ize, ..., Frédéric Taïeb, ..., Laure David, ..., Priscilla Branchu, Éric Oswald, Journal of Extracellular Vesicles 2025. DOI: 10.1002/jev2.70032

    Development of intimin-enriched outer membrane vesicles (OMVs) as a vaccine to control intestinal carriage of Enterohemorrhagic Escherichia coli. Asja Garling, Cécile Goursat, ..., Jean‐Philippe Nougayrède, Éric Oswald, Frédéric Auvray, Priscilla Branchu, Vaccine 2025. DOI: 10.1016/j.vaccine.2025.126899

    Rethinking the role of animals in antimicrobial resistance. Elissa Khamisse, Xavier Bertrand, et al., The Lancet Microbe 2025. DOI: 10.1016/j.lanmic.2025.101248

    Kinetics of molecular patterns captured by mannose-binding lectin in septic shock correlate with clinical outcome: a monocentric prospective observational study. A. Bicart-See, Fanny Vardon‐Bounes, ..., Éric Oswald, Intensive Care Medicine Experimental 2025. DOI: 10.1186/s40635-025-00832-x

    Humans as a potential reservoir for the emerging ST301 Shiga toxin-producing Escherichia coli clones of serotype O80:H2?. Frédéric Auvray, Federica Gigliucci, ..., Éric Oswald, Clinical Microbiology and Infection 2025. DOI: 10.1016/j.cmi.2025.05.018

    Bacterial nanoparticles as a potent and safe alternative to BCG for bladder cancer immunotherapy. Marine Colson, Arthur Aubry, ..., Éric Oswald, Laure David, Cancer Gene Therapy 2025. DOI: 10.1038/s41417-025-00984-8

    Prevalence and characterization of the seven major serotypes of Shiga toxin-producing Escherichia coli (STEC) in veal calves slaughtered in France. Frédéric Auvray, Clémence Bièche-Terrier, ..., Éric Oswald, et al., Veterinary Microbiology 2023. DOI: 10.1016/j.vetmic.2023.109754

    Oxygen concentration modulates colibactin production. Nadège Bossuet‐Greif, Cécile Guyonnet, ..., Priscilla Branchu, Éric Oswald, Jean‐Philippe Nougayrède, Gut Microbes 2023. DOI: 10.1080/19490976.2023.2222437

    HlyF, an underestimated virulence factor of uropathogenic Escherichia coli. Camille V. Chagneau, Delphine Payros, ..., Priscilla Branchu, ..., Jean‐Philippe Nougayrède, ..., Éric Oswald, Clinical Microbiology and Infection 2023. DOI: 10.1016/j.cmi.2023.07.024

    Outer membrane vesicles produced by pathogenic strains of *Escherichia coli* block autophagic flux and exacerbate inflammasome activation. Laure David, Frédéric Taïeb, ..., Éric Oswald, Autophagy 2022. DOI: 10.1080/15548627.2022.2054040

    A novel toxic effect of foodborne trichothecenes: The exacerbation of genotoxicity. Marion Garofalo, Delphine Payros, ..., Éric Oswald, Jean‐Philippe Nougayrède, et al., Environmental Pollution 2022. DOI: 10.1016/j.envpol.2022.120625

    Wild Boars as Reservoir of Highly Virulent Clone of Hybrid Shiga Toxigenic and Enterotoxigenic *Escherichia coli* Responsible for Edema Disease, France. Alexandre Perrat, Priscilla Branchu, ..., Frédéric Auvray, Éric Oswald, Emerging Infectious Diseases 2022. DOI: 10.3201/eid2802.211491

    Uncoupling the Hsp90 and DnaK chaperone activities revealed the in vivo relevance of their collaboration in bacteria. Marie Corteggiani, Nadège Bossuet‐Greif, Jean‐Philippe Nougayrède, ..., Éric Oswald, et al., Proceedings of the National Academy of Sciences 2022. DOI: 10.1073/pnas.2201779119

    The pks island: a bacterial Swiss army knife? Colibactin: beyond DNA damage and cancer. Camille V. Chagneau, Delphine Payros, ..., Frédéric Auvray, Jean‐Philippe Nougayrède, Éric Oswald, Trends in Microbiology 2022. DOI: 10.1016/j.tim.2022.05.010

    A Toxic Friend: Genotoxic and Mutagenic Activity of the Probiotic Strain Escherichia coli Nissle 1917. Jean‐Philippe Nougayrède, Camille V. Chagneau, Jean‐Paul Motta, ..., Frédéric Taïeb, ..., Éric Oswald, mSphere 2021. DOI: 10.1128/msphere.00624-21

    Insights into evolution and coexistence of the colibactin- and yersiniabactin secondary metabolite determinants in enterobacterial populations. Haleluya Wami, Alexander Wallenstein, ..., Éric Oswald, et al., Microbial Genomics 2021. DOI: 10.1099/mgen.0.000577

    Uropathogenic E. coli induces DNA damage in the bladder. Camille V. Chagneau, Clémence Massip, ..., Jean‐Paul Motta, ..., Marie‐Paule Roth, Hélène Coppin, ..., Jean‐Philippe Nougayrède, Éric Oswald, PLOS Pathogens 2021. DOI: 10.1371/journal.ppat.1009310

    The Genotoxin Colibactin Shapes Gut Microbiota in Mice. Sophie Tronnet, Pauline Floch, ..., Éric Oswald, mSphere 2020. DOI: 10.1128/msphere.00589-20

    Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917. Clémence Massip, Priscilla Branchu, ..., Jean‐Philippe Nougayrède, Éric Oswald, PLOS Pathogens 2019. DOI: 10.1371/journal.ppat.1008029

    The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells. Nadège Bossuet‐Greif, Julien Vignard, Frédéric Taïeb, ..., Éric Oswald, Jean‐Philippe Nougayrède, mBio 2018. DOI: 10.1128/mbio.02393-17

    The Food Contaminant Deoxynivalenol Exacerbates the Genotoxicity of Gut Microbiota. Delphine Payros, Ulrich Dobrindt, ..., Éric Oswald, et al., mBio 2017. DOI: 10.1128/mbio.00007-17

    Retrograde Trafficking Inhibitor of Shiga Toxins Reduces Morbidity and Mortality of Mice Infected with Enterohemorrhagic Escherichia coli. Thomas Sécher, Ayaka Shima, ..., Éric Oswald, Antimicrobial Agents and Chemotherapy 2015. DOI: 10.1128/aac.00455-15

    The Genotoxin Colibactin Exacerbates Lymphopenia and Decreases Survival Rate in Mice Infected With Septicemic Escherichia coli. Ingrid Marcq, Pascal Martin, ..., Jean‐Philippe Nougayrède, ..., Éric Oswald, Journal of Infectious Diseases 2014. DOI: 10.1093/infdis/jiu071

    Interplay between Siderophores and Colibactin Genotoxin Biosynthetic Pathways in Escherichia coli. Patricia Martín, Ingrid Marcq, ..., Jean‐Philippe Nougayrède, ..., Éric Oswald, PLoS Pathogens 2013. DOI: 10.1371/journal.ppat.1003437

    *Escherichia coli* induces DNA damage in vivo and triggers genomic instability in mammalian cells. Gabriel Cuevas‐Ramos, C. Petit, ..., Éric Oswald, Jean‐Philippe Nougayrède, Proceedings of the National Academy of Sciences 2010. DOI: 10.1073/pnas.1001261107

    Pathogenic Bacteria Target NEDD8-Conjugated Cullins to Hijack Host-Cell Signaling Pathways. Grégory Jubelin, Frédéric Taïeb, ..., Jean‐Philippe Nougayrède, ..., Éric Oswald, PLoS Pathogens 2010. DOI: 10.1371/journal.ppat.1001128

    *Escherichia coli* Induces DNA Double-Strand Breaks in Eukaryotic Cells. Jean‐Philippe Nougayrède, Stefan Homburg, Frédéric Taïeb, ..., Éric Oswald, Science 2006. DOI: 10.1126/science.1127059

    Role of Tir and Intimin in the Virulence of Rabbit Enteropathogenic*Escherichia coli*Serotype O103:H2. Olivier Marchès, Jean‐Philippe Nougayrède, ..., Éric Oswald, Infection and Immunity 2000. DOI: 10.1128/iai.68.4.2171-2182.2000

    A new cytolethal distending toxin (CDT) from *Escherichia coli* producing CNF2 blocks HeLa cell division in G2/M phase. Sylvie Pérès, Olivier Marchès, ..., Jean‐Philippe Nougayrède, ..., Éric Oswald, Molecular Microbiology 1997. DOI: 10.1046/j.1365-2958.1997.4181785.x