EQUIPE 3: INTERACTIONS NEURO-IMMUNES INTESTINALES

​gilles dietrich

Chef d'équipe

DESCRIPTION DU PROGRAMME DE RECHERCHE

Nous sommes un groupe en neuro-immunologie dédié à la neuro-gastro-entérologie avec un accent particulier sur l'inflammation intestinale, la douleur viscérale et l'axe intestin-cerveau et sa pertinence dans la régulation des fonctions digestives.
Objectifs:
  1. Identifier des composés lipidiques dérivés du microbiote et impliqués dans la régulation de l'inflammation intestinale et de la douleur
  2. Déchiffrer les mécanismes de régulation endogène de l'inflammation et la douleur viscérale par les opioïdes dérivés de cellules T
  3. Analyser les effets des médiateurs liés à l'inflammation sur l'activité du système nerveux entérique et leurs conséquences sur le métabolisme​

Membres 

MODELES CELLULAIRE ET ANIMAUX / METHODES

PUBLICATIONS

  1. Basso L , Boué J, Augé C, Deraison C, Blanpied C, Cenac N, Lluel P, Vergnolle N, Dietrich G.Mobilization of CD4+ T lymphocytes in inflamed mucosa reduces pain in colitis mice: towards a vaccinal strategy to alleviate inflammatory visceral pain
    Pain, accepted 7 nov 2017
  2. T Pérez-Berezo, J Pujo, P Martin, P Le-Faouder, J-M Galano, A Guy, C Knauf, J-C Tabet, S Tronnet, F Barreau, M Heuillet, G Dietrich, J Bertrand-Michel, T Durand, E Oswald, and N Cenac. Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917, in press, Nat comm. 
  3. Anne Abot, Lucie Murphy, Claude Knauf. Cahiers de nutrition et de diététique, in press.
  4. Bonnart C, Feuillet G, Vasseur V, Cenac N, Vergnolle N, Blanchard N. Protease-Activated Receptor 2 contributes to Toxoplasma gondii-mediated gut inflammation. 2017 Sep 7. Parasite Immunol.
  5. Casemayou A, Fournel A, Bagattin A, Schanstra J, Belliere J, Decramer S, Marsal D, Gillet M, Chassaing N, Huart A, Pontoglio M, Knauf C, Bascands JL, Chauveau D, Faguer S. Hepatocyte Nuclear Factor-1β Controls Mitochondrial Respiration in Renal Tubular Cells.  J Am Soc Nephrol. 2017 Jul 24.
  6. Bashashati M, Fichna J, Piscitelli F, Capasso R, Izzo AA, Sibaev A, Timmermans JP, Cenac N, Vergnolle N, Di Marzo V, Storr M. Targeting fatty acid amide hydrolase and transient receptor potential vanilloid-1 simultaneously to modulate colonic motility and visceral sensation in the mouse: A pharmacological intervention with N-arachidonoyl-serotonin (AA-5-HT). 2017 Jul 11, Neurogastroenterol Motil. 
  7. Ramírez S, Gómez-Valadés AG, Schneeberger M, Varela L, Haddad-Tóvolli R, Altirriba J, Noguera E, Drougard A, Flores-Martínez Á, Imbernón M, Chivite I, Pozo M, Vidal-Itriago A, Garcia A, Cervantes S, Gasa R, Nogueiras R, Gama-Pérez P, Garcia-Roves PM, Cano DA, Knauf C, Servitja JM, Horvath TL, Gomis R, Zorzano A, Claret M. Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control. Cell Metab. 2017 Jun 6;25(6):1390-1399
  8. Reiss D., R.A. Ceredig, , T. Secher, J. Boue, F. Barreau,  G. Dietrich and C. Gavériaux-Ruff .. Mu and delta opioid receptor knockout mice show increased colonic sensitivity. 2017 Apr 21, Eur J. Pain. 21: 623-634.
  9. Basso L., L. Garnier, A. Bessac, J. Boue, C. Blanpied,  N. Cenac, S. Laffont and G. Dietrich. 2017. T lymphocyte-derived enkephalins reduce Th1/Th17 colitis and associated pain in mice. 2017 Apr 19, J Gastroenterol.
  10. Nicolas S, Blasco-Baque V, Fournel A, Gilleron J, Klopp P, Waget A, Ceppo F, Marlin A, Padmanabhan R, Iacovoni JS, Tercé F, Cani PD, Tanti JF, Burcelin R, Knauf C, Cormont M, Serino M.Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism. Mol Syst Biol. 2017 Mar 16;13(3):921.
  11. Al Nabhani Z., G. Dietrich, JP. Hugot and F. Barreau. Nod2: the intestinal gate keeper. 2017 Mar 2, PLoS Pathog. 13(3):e1006177
  12. Lecoutre S, Marousez L, Drougard A, Knauf C, Guinez C, Eberlé D, Laborie C, Vieau D, Lesage J, Breton C. Maternal undernutrition programs the apelinergic system of adipose tissue in adult male rat offspring. J Dev Orig Health Dis. 2017 Feb;8(1):3-7.
  13. Fournel A, Drougard A, Duparc T, Marlin A, Brierley SM, Castro J, Le-Gonidec S, Masri B, Colom A, Lucas A, Rousset P, Cenac N, Vergnolle N, Valet P, Cani PD, Knauf C. Apelin targets gut contraction to control glucose metabolism via the brain. Gut. 2017 Feb;66(2):258-269
  14. Rolland-Fourcade C, Denadai-Souza A, Cirillo C, Lopez C, Jaramillo JO, Desormeaux C, Cenac N, Motta JP, Larauche M, Taché Y, Berghe PV, Neunlist M, Coron E, Kirzin S, Portier G, Bonnet D, Alric L, Vanner S, Deraison C, Vergnolle N. Epithelial expression and function of trypsin-3 in irritable bowel syndrome. 2017 Jan 17. Gut
  15. Viola JR, Lemnitzer P, Jansen Y, Csaba G, Winter C, Neideck C, Silvestre-Roig C, Dittmar G, Döring Y, Drechsler M, Weber C, Zimmer R, Cenac N, Soehnlein O. Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice. 2016 Oct 14, Circ Res
  16. Gaudenzio N, Sibilano R, Marichal T, Starkl P, Reber LL, Cenac N, McNeil BD, Dong X, Hernandez JD, Sagi-Eisenberg R, Hammel I, Roers A, Valitutti S, Tsai M, Espinosa E, Galli SJ. Different activation signals induce distinct mast cell degranulation strategies.  2016 Oct 3, J Clin Invest.
  17. Henry CO, Dalloneau E, Pérez-Berezo MT, Plata C, Wu Y, Guillon A, Morello E, Aimar RF, Potier-Cartereau M, Esnard F, Coraux C, Börnchen C, Kiefmann R, Vandier C, Touqui L, Valverde MA, Cenac N, Si-Tahar M. In vitro and in vivo evidence for an inflammatory role of the calcium channel TRPV4 in lung epithelium: Potential involvement in cystic fibrosis. 2016 Sep 1. Am J Physiol Lung Cell Mol Physiol.
  18. Drougard A, Fournel A, Marlin A, Meunier E, Abot A, Bautzova T, Duparc T, Louche K, Batut A, Lucas A, Le-Gonidec S, Lesage J, Fioramonti X, Moro C, Valet P, Cani PD, Knauf C. Central chronic apelin infusion decreases energy expenditure and thermogenesis in mice. Sci Rep. 2016 Aug 23;6:31849
  19. Nasri I, Bonnet D, Zwarycz B, d'Aldebert E, Khou S, Mezghani-Jarraya R, Quaranta M, Rolland C, Bonnart C, Mas E, Ferrand A, Cenac N, Magness S, Van Landeghem L, Vergnolle N, Racaud-Sultan C.PAR2-dependent activation of GSK3β regulates the survival of colon stem/progenitor cells. 2016 Aug 1, Am J Physiol Gastrointest Liver Physiol.
  20. Tcherniuk S, Cenac N, Comte M, Frouard J, Errazuriz-Cerda E, Galabov A, Morange PE, Vergnolle N, Si-Tahar M, Alessi MC, Riteau B. Formyl Peptide Receptor 2 Plays a Deleterious Role During Influenza A Virus Infections. 2016 Jul 15. J Infect Dis.
  21. Basso L., J. Boue, K. Mahiddine, C. Blanpied, S. Robiou-du-Pont, N. Vergnolle, C. Deraison and G. Dietrich. 2016 Jun 1. Endogenous analgesia mediated by CD4+ T lymphocytes is dependent on enkephalins in mice. J. Neuro. Inflamm. 13:132.
  22. Cani PD, Knauf C. How gut microbes talk to organs: The role of endocrine and nervous routes. Mol Metab. 2016 May 27; 5(9):743-52.
  23. Cenac N, Castro M, Desormeaux C, Colin P, Sie M, Ranger M, Vergnolle N. A novel orally administered trimebutine compound (GIC-1001) is anti-nociceptive and features peripheral opioid agonistic activity and Hydrogen Sulphide-releasing capacity in mice. 2016 May 20. Eur J Pain.
  24. Coquenlorge S, Van Landeghem L, Jaulin J, Cenac N, Vergnolle N, Duchalais E, Neunlist M, Rolli-Derkinderen M. The arachidonic acid metabolite 11β-ProstaglandinF2α controls intestinal epithelial healing: deficiency in patients with Crohn's disease. 2016 May 3, Sci Rep
  25. Rolland M, Li X, Sellier Y, Martin H, Perez-Berezo T, Rauwel B, Benchoua A, Bessières B, Aziza J, Cenac N, Luo M, Casper C, Peschanski M, Gonzalez-Dunia D, Leruez-Ville M, Davrinche C, Chavanas S. PPARγ Is Activated during Congenital Cytomegalovirus Infection and Inhibits Neuronogenesis from Human Neural Stem Cells. 2016 Apr 14, PLoS Pathog. 
  26. Fournel A, Marlin A, Abot A, Pasquio C, Cirillo C, Cani PD, Knauf C. Glucosensing in the gastrointestinal tract: Impact on glucose metabolism. Am J Physiol Gastrointest Liver Physiol. 2016 May 1;310(9):G645-58. doi: 10.1152/ajpgi.00015.2016. Epub 2016 Mar 3
  27. Hanssens S, Marx-Deseure A, Lecoutre S, Butruille L, Fournel A, Knauf C, Besengez C, Breton C, Storme L, Deruelle P, Lesage J. Maternal obesity alters the apelinergic system at the feto-maternal interface. Placenta. 2016 Mar;39:41-4.
  28. Mayeur S, Wattez JS, Lukaszewski MA, Lecoutre S, Butruille L, Drougard A, Eberlé D, Bastide B, Laborie C, Storme L, Knauf C, Vieau D, Breton C, Lesage J. Apelin Controls Fetal and Neonatal Glucose Homeostasis and Is Altered by Maternal Undernutrition. Diabetes. 2016 Mar;65(3):554-60.
  29. Pochard C, Coquenlorge S, Jaulin J, Cenac N, Vergnolle N, Meurette G, Freyssinet M, Neunlist M, Rolli-Derkinderen M. Defects in 15-HETE Production and Control of Epithelial Permeability by Human Enteric Glial Cells from Patients with Crohn's Disease. 2016 Jan, Gastroenterology
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