éQUIPE 3 INTéRACTIONS NEURO-IMMUNES INTESTINALES |
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éQUIPE 3: INTERACTIONS NEURO-IMMUNES INTESTINALES
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DESCRIPTION DU PROGRAMME DE RECHERCHE
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L'inflammation intestinale s’accompagne souvent de douleurs abdominales, d’une hypercontractilité intestinale et d’altérations du métabolisme, notamment une hyperglycémie chronique. Notre groupe de recherche en neuro-gastro-entérologie vise principalement à mieux comprendre les mécanismes endogènes de régulation de la douleur viscérale et des fonctions digestives dans un contexte inflammatoire comprenant aussi les troubles endocriniens et métaboliques tels que l'obésité et le diabète.
Plus précisément, nous étudions les effets de la flore intestinale et des opioïdes d’origine hématopoïétique sur les systèmes nerveux entériques extrinsèque et intrinsèque et leurs répercussions sur l’inflammation, la douleur viscérale et le métabolisme du glucose |
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membres
anciens membres
MODèLES CELLULAIRE ET ANIMAUX / MéTHODES
- Mesure de la douleur in vivo (réponse viscéro-motrice, filaments de von Frey)
- Identification et quantification des lipides par spectrométrie de masse
- Cultures primaires de neurones sensitifs humains / murins
- Métabolisme des lipides et du glucose (in vitro et in vivo)
- Mesure de la libération de NO et de H2O2 en temps réel dans les tissus in vivo et in vitro
- Mesure des contractions intestinales (télémétrie, isotonique)
- Modèles animaux de colite
- Modèles animaux de douleur viscérale
- Modèles animaux de troubles métaboliques
publications
2018
Bautzova T, Hockley JRF, Perez-Berezo T, Pujo J, Tranter MM, Desormeaux C, Barbaro MR, Basso L, Le Faouder P, Rolland C, Malapert P, Moqrich A, Eutamene H, Denadai-Souza A, Vergnolle N, St John Smith E, Hughes DI, Barbara G, Dietrich G, Bulmer D, Cenac N. (2018) 5-oxoETE triggers nociception in constipation predominant irritable bowel syndrome through MAS-related G protein coupled receptor D. Sci. Signal. In press
Desormeaux C, Bautzova T, Garcia-Caraballo S, Rolland C, Barbaro MR, Brierley SM, Barbara G, Vergnolle N, Cenac N. (2018) Protease-activated receptor 1 is implicated in irritable bowel syndrome mediators-induced signaling to thoracic human sensory neurons. Pain. 159(7):1257-1267.
Abot A, Lucas A, Bautzova T, Bessac A, Fournel A, Le-Gonidec S, Valet P, Moro C, Cani PD, Knauf C. (2018) Galanin enhances systemic glucose metabolism through enteric Nitric Oxide Synthase-expressed neurons. Mol Metab. 10:100-108.
Basso L, Boué J, Augé C, Deraison C, Blanpied C, Cenac N, Lluel P, Vergnolle N, Dietrich G. (2018) Mobilization of CD4+ T lymphocytes in inflamed mucosa reduces pain in colitis mice: toward a vaccinal strategy to alleviate inflammatory visceral pain. Pain. 159(2):331-341.
Basso L, Garnier L, Bessac A, Boué J, Blanpied C, Cenac N, Laffont S, Dietrich G. (2018) T-lymphocyte-derived enkephalins reduce Th1/Th17 colitis and associated pain in mice.
J Gastroenterol. 53(2):215-226.
Bessac A, Cani PD, Meunier E, Dietrich G, Knauf C. (2018) Inflammation and Gut-Brain Axis During Type 2 Diabetes: Focus on the Crosstalk Between Intestinal Immune Cells and Enteric Nervous System. Front Neurosci. 12:725.
Abot A, Cani PD, Knauf C. (2018) Impact of Intestinal Peptides on the Enteric Nervous System: Novel Approaches to Control Glucose Metabolism and Food Intake. Front Endocrinol. 9:328.
Rezg R, Abot A, Mornagui B, Aydi S, Knauf C. (2018) Effects of Bisphenol S on hypothalamic neuropeptides regulating feeding behavior and apelin/APJ system in mice. Ecotoxicol Environ Saf. 161:459-466.
Guivarc'h E, Buscato M, Guihot AL, Favre J, Vessières E, Grimaud L, Wakim J, Melhem NJ, Zahreddine R, Adlanmerini M, Loufrani L, Knauf C, Katzenellenbogen JA, Katzenellenbogen BS, Foidart JM, Gourdy P, Lenfant F, Arnal JF, Henrion D, Fontaine C. (2018) Predominant Role of Nuclear Versus Membrane Estrogen Receptor α in Arterial Protection: Implications for Estrogen Receptor α Modulation in Cardiovascular Prevention/Safety. J Am Heart Assoc. 7(13).
Rastelli M, Knauf C, Cani PD. (2018) Gut Microbes and Health: A Focus on the Mechanisms Linking Microbes, Obesity, and Related Disorders. Obesity. 26(5):792-800.
2017
Pérez-Berezo T, Pujo J, Martin P, Le Faouder P, Galano JM, Guy A, Knauf C, Tabet JC, Tronnet S, Barreau F, Heuillet M, Dietrich G, Bertrand-Michel J, Durand T, Oswald E, Cenac N. (2017) Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917. Nat Commun. 8(1):1314.
Fournel A, Drougard A, Duparc T, Marlin A, Brierley SM, Castro J, Le-Gonidec S, Masri B, Colom A, Lucas A, Rousset P, Cenac N, Vergnolle N, Valet P, Cani PD, Knauf C. (2017) Apelin targets gut contraction to control glucose metabolism via the brain. Gut. 66(2):258-269.
Reiss D, Ceredig RA, Secher T, Boue J, Barreau F, Dietrich G, Gavériaux-Ruff C. (2017) Mu and delta opioid receptor knockout mice show increased colonic sensitivity. Eur J. Pain. 21:623-634.
Al Nabhani Z, Dietrich G, Hugot JP, Barreau F. (2017) Nod2: the intestinal gate keeper. PLoS Pathog. 13(3):e1006177
Alessi MC, Cenac N, Si-Tahar M, Riteau B. (2017) FPR2: A Novel Promising Target for the Treatment of Influenza. Front Microbiol. 8:1719.
Bonnart C, Feuillet G, Vasseur V, Cenac N, Vergnolle N, Blanchard N. (2017) Protease-activated receptor 2 contributes to Toxoplasma gondii-mediated gut inflammation. Parasite Immunol. 39(11).
Bashashati M, Fichna J, Piscitelli F, Capasso R, Izzo AA, Sibaev A, Timmermans JP, Cenac N, Vergnolle N, Di Marzo V, Storr M. (2017) Targeting fatty acid amide hydrolase and transient receptor potential vanilloid-1 simultaneously to modulate colonic motility and visceral sensation in the mouse: A pharmacological intervention with N-arachidonoyl-serotonin (AA-5-HT). Neurogastroenterol Motil. 29(12).
Rolland-Fourcade C, Denadai-Souza A, Cirillo C, Lopez C, Jaramillo JO, Desormeaux C, Cenac N, Motta JP, Larauche M, Taché Y, Berghe PV, Neunlist M, Coron E, Kirzin S, Portier G, Bonnet D, Alric L, Vanner S, Deraison C, Vergnolle N. (2017) Epithelial expression and function of trypsin-3 in irritable bowel syndrome. Gut. 66(10):1767-1778.
Casemayou A, Fournel A, Bagattin A, Schanstra J, Belliere J, Decramer S, Marsal D, Gillet M, Chassaing N, Huart A, Pontoglio M, Knauf C, Bascands JL, Chauveau D, Faguer S. (2017) Hepatocyte Nuclear Factor-1β Controls Mitochondrial Respiration in Renal Tubular Cells. J Am Soc Nephrol. 28(11):3205-3217.
Ramírez S, Gómez-Valadés AG, Schneeberger M, Varela L, Haddad-Tóvolli R, Altirriba J, Noguera E, Drougard A, Flores-Martínez Á, Imbernón M, Chivite I, Pozo M, Vidal-Itriago A, Garcia A, Cervantes S, Gasa R, Nogueiras R, Gama-Pérez P, Garcia-Roves PM, Cano DA, Knauf C, Servitja JM, Horvath TL, Gomis R, Zorzano A, Claret M. (2017) Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control. Cell Metab. 25(6):1390-1399.
Nicolas S, Blasco-Baque V, Fournel A, Gilleron J, Klopp P, Waget A, Ceppo F, Marlin A, Padmanabhan R, Iacovoni JS, Tercé F, Cani PD, Tanti JF, Burcelin R, Knauf C, Cormont M, Serino M. (2017) Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism. Mol Syst Biol. 13(3):921.
Lecoutre S, Marousez L, Drougard A, Knauf C, Guinez C, Eberlé D, Laborie C, Vieau D, Lesage J, Breton C. (2017) Maternal undernutrition programs the apelinergic system of adipose tissue in adult male rat offspring. J Dev Orig Health Dis. 8(1):3-7.
Dietrich G, Barreau F. (2017) Le microbiote : un acteur décisif dans le syndrome de l’intestin irritable ? mt Pédiatrie. 20 :203-212.
2016
Cani PD, Knauf C. (2016) How gut microbes talk to organs: The role of endocrine and nervous routes. Mol Metab.5(9):743-52.
Drougard A, Fournel A, Marlin A, Meunier E, Abot A, Bautzova T, Duparc T, Louche K, Batut A, Lucas A, Le-Gonidec S, Lesage J, Fioramonti X, Moro C, Valet P, Cani PD, Knauf C. Central chronic apelin infusion decreases energy expenditure and thermogenesis in mice. (2016) Sci Rep. 23;6:31849.
Fournel A, Marlin A, Abot A, Pasquio C, Cirillo C, Cani PD, Knauf C. (2016) Glucosensing in the gastrointestinal tract: Impact on glucose metabolism. Am J Physiol Gastrointest Liver Physiol. 310(9):G645-58.
Basso L, Boue J, Mahiddine K, Blanpied C, Robiou-du-Pont S, Vergnolle N, Deraison C, Dietrich G. (2016) Endogenous analgesia mediated by CD4+ T lymphocytes is dependent on enkephalins in mice. J. Neuro. Inflamm. 13:132.
Cenac N, Castro M, Desormeaux C, Colin P, Sie M, Ranger M, Vergnolle N. (2016) A novel orally administered trimebutine compound (GIC-1001) is anti-nociceptive and features peripheral opioid agonistic activity and Hydrogen Sulphide-releasing capacity in mice. Eur J Pain. 20(5):723-30.
Gaudenzio N, Sibilano R, Marichal T, Starkl P, Reber LL, Cenac N, McNeil BD, Dong X, Hernandez JD, Sagi-Eisenberg R, Hammel I, Roers A, Valitutti S, Tsai M, Espinosa E, Galli SJ. (2016) Different activation signals induce distinct mast cell degranulation strategies.
J Clin Invest. 126(10):3981-3998.
Viola JR, Lemnitzer P, Jansen Y, Csaba G, Winter C, Neideck C, Silvestre-Roig C, Dittmar G, Döring Y, Drechsler M, Weber C, Zimmer R, Cenac N, Soehnlein O. (2016) Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice. Circ Res. 119(9):1030-1038.
Henry CO, Dalloneau E, Pérez-Berezo MT, Plata C, Wu Y, Guillon A, Morello E, Aimar RF, Potier-Cartereau M, Esnard F, Coraux C, Börnchen C, Kiefmann R, Vandier C, Touqui L, Valverde MA, Cenac N, Si-Tahar M. (2016) In vitro and in vivo evidence for an inflammatory role of the calcium channel TRPV4 in lung epithelium: Potential involvement in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol. 311(3):L664-75.
Nasri I, Bonnet D, Zwarycz B, d'Aldebert E, Khou S, Mezghani-Jarraya R, Quaranta M, Rolland C, Bonnart C, Mas E, Ferrand A, Cenac N, Magness S, Van Landeghem L, Vergnolle N, Racaud-Sultan C. (2016) PAR2-dependent activation of GSK3β regulates the survival of colon stem/progenitor cells. Am J Physiol Gastrointest Liver Physiol. 311(2):G221-36.
Coquenlorge S, Van Landeghem L, Jaulin J, Cenac N, Vergnolle N, Duchalais E, Neunlist M, Rolli-Derkinderen M. (2016) The arachidonic acid metabolite 11β-ProstaglandinF2α controls intestinal epithelial healing: deficiency in patients with Crohn's disease. Sci Rep. 6:25203.
Rolland M, Li X, Sellier Y, Martin H, Perez-Berezo T, Rauwel B, Benchoua A, Bessières B, Aziza J, Cenac N, Luo M, Casper C, Peschanski M, Gonzalez-Dunia D, Leruez-Ville M, Davrinche C, Chavanas S. (2016) PPARγ Is Activated during Congenital Cytomegalovirus Infection and Inhibits Neuronogenesis from Human Neural Stem Cells. PLoS Pathog. 12(4):e1005547.
Tcherniuk S, Cenac N, Comte M, Frouard J, Errazuriz-Cerda E, Galabov A, Morange PE, Vergnolle N, Si-Tahar M, Alessi MC, Riteau B. (2016) Formyl Peptide Receptor 2 Plays a Deleterious Role During Influenza A Virus Infections. J Infect Dis. 214(2):237-47.
Pochard C, Coquenlorge S, Jaulin J, Cenac N, Vergnolle N, Meurette G, Freyssinet M, Neunlist M, Rolli-Derkinderen M. (2016) Defects in 15-HETE Production and Control of Epithelial Permeability by Human Enteric Glial Cells From Patients With Crohn's Disease. Gastroenterology. 150(1):168-80.
Hanssens S, Marx-Deseure A, Lecoutre S, Butruille L, Fournel A, Knauf C, Besengez C, Breton C, Storme L, Deruelle P, Lesage J. (2016) Maternal obesity alters the apelinergic system at the feto-maternal interface. Placenta. 39:41-4.
Mayeur S, Wattez JS, Lukaszewski MA, Lecoutre S, Butruille L, Drougard A, Eberlé D, Bastide B, Laborie C, Storme L, Knauf C, Vieau D, Breton C, Lesage J. (2016) Apelin Controls Fetal and Neonatal Glucose Homeostasis and Is Altered by Maternal Undernutrition. Diabetes. 65(3):554-60.
2015
Cenac N, Bautzova T, Le Faouder P, Veldhuis NA, Poole DP, Rolland C, Bertrand J, Liedtke W, Dubourdeau M, Bertrand-Michel J, Zecchi L, Stanghellini V, Bunnett NW, Barbara G, Vergnolle N. (2015) Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome. Gastroenterology. 149(2):433-44.e7.
Gobbetti T, Ducheix S, le Faouder P, Perez T, Riols F, Boue J, Bertrand-Michel J, Dubourdeau M, Guillou H, Perretti M, Vergnolle N, Cenac N. (2015) Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor. Br J Pharmacol. 172(3):910-23.
Drougard A, Fournel A, Valet P, Knauf C. (2015) Impact of hypothalamic reactive oxygen species in the regulation of energy metabolism and food intake. Front Neurosci. 9:56.
Basso L, Bourreille A, Dietrich G. (2015) Intestinal inflammation and pain management. Curr. Opin. Pharmacol. 25:50-55.
Federici Canova D, Pavlov AM, Norling LV, Gobbetti T, Brunelleschi S, Le Fauder P, Cenac N, Sukhorukov GB, Perretti M. (2015) Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response. J Control Release. 217:284-92.
Leghmar K, Cenac N, Rolland M, Martin H, Rauwel B, Bertrand-Michel J, Le Faouder P, Bénard M, Casper C, Davrinche C, Fournier T, Chavanas S. (2015) Cytomegalovirus Infection Triggers the Secretion of the PPARγ Agonists 15-Hydroxyeicosatetraenoic Acid (15-HETE) and 13-Hydroxyoctadecadienoic Acid (13-HODE) in Human Cytotrophoblasts and Placental Cultures. PLoS One. 10(7):e0132627.
Boal F, Roumegoux J, Alfarano C, Timotin A, Calise D, Anesia R, Drougard A, Knauf C, Lagente C, Roncalli J, Desmoulin F, Tronchere H, Valet P, Parini A, Kunduzova O. (2015) Apelin regulates FoxO3 translocation to mediate cardioprotective responses to myocardial injury and obesity. Sci Rep. 5:16104.
Chaves-Almagro C, Castan-Laurell I, Dray C, Knauf C, Valet P, Masri B. (2015) Apelin receptors: From signaling to antidiabetic strategy. Eur J Pharmacol. 763(Pt B):149-59.
Masri B, Dray C, Knauf C, Valet P, Castan-Laurell I. (2015) The APJ receptor: a new therapeutic approach in diabetic treatment. Med Sci (Paris). 31(3):275-81.
Lapointe T, Basso L, Iftinca M, Flynn R, Chapman K, Dietrich G, Vergnolle N, Altier C. (2015) TRPV1 sensitization mediates post-inflammatory visceral pain following acute colitis. American Journal of Physiology - Gastrointestinal and Liver Physiology. 309:G87-G99.
2014
Boue J, Basso L, Cenac N, Blanpied C, Rolli-Derkinderen M, Neunlist M, Vergnolle N, Dietrich G. (2014) Endogenous regulation of visceral pain via production of opioids by colitogenic CD4(+) T cells in mice. Gastroenterology. 146(1):166-75.
Drougard A, Duparc T, Brenachot X, Carneiro L, Gouazé A, Fournel A, Geurts L, Cadoudal T, Prats AC, Pénicaud L, Vieau D, Lesage J, Leloup C, Benani A, Cani PD, Valet P, Knauf C. (2014) Hypothalamic apelin/reactive oxygen species signaling controls hepatic glucose metabolism in the onset of diabetes. Antioxid Redox Signal. 20(4):557-73.
Basso L, Boue J, Bourreille A, Dietrich G. (2014) Endogenous regulation of inflammatory pain by T cell-derived opioids: when friend turns to foe. Inflamm. Bowel Dis. 20:1870-1977.
Gobbetti T, Coldewey SM, Chen J, McArthur S, le Faouder P, Cenac N, Flower RJ, Thiemermann C, Perretti M. (2014) Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. Proc Natl Acad Sci U S A. 111(52):18685-90.
Fichna J, Sobczak M, Mokrowiecka A, Cygankiewicz AI, Zakrzewski PK, Cenac N, Sałaga M, Timmermans JP, Vergnolle N, Małecka-Panas E, Krajewska WM, Storr M. (2014) Activation of the endogenous nociceptin system by selective nociceptin receptor agonist SCH 221510 produces antitransit and antinociceptive effect: a novel strategy for treatment of diarrhea-predominant IBS. Neurogastroenterol Motil. 26(11):1539-50.
Ochoa-Cortes F, Guerrero-Alba R, Valdez-Morales EE, Spreadbury I, Barajas-Lopez C, Castro M, Bertrand J, Cenac N, Vergnolle N, Vanner SJ. (2014) Chronic stress mediators act synergistically on colonic nociceptive mouse dorsal root ganglia neurons to increase excitability. Neurogastroenterol Motil. 26(3):334-45.
Abot A, Fontaine C, Buscato M, Solinhac R, Flouriot G, Fabre A, Drougard A, Rajan S, Laine M, Milon A, Muller I, Henrion D, Adlanmerini M, Valéra MC, Gompel A, Gerard C, Péqueux C, Mestdagt M, Raymond-Letron I, Knauf C, Ferriere F, Valet P, Gourdy P, Katzenellenbogen BS, Katzenellenbogen JA, Lenfant F, Greene GL, Foidart JM, Arnal JF. (2014) The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation. EMBO Mol Med. 6(10):1328-46.
Geurts L, Neyrinck AM, Delzenne NM, Knauf C, Cani PD. Gut microbiota controls adipose tissue expansion, gut barrier and glucose metabolism: novel insights into molecular targets and interventions using prebiotics. (2014) Benef Microbes. 5(1):3-17.
Bautzova T, Hockley JRF, Perez-Berezo T, Pujo J, Tranter MM, Desormeaux C, Barbaro MR, Basso L, Le Faouder P, Rolland C, Malapert P, Moqrich A, Eutamene H, Denadai-Souza A, Vergnolle N, St John Smith E, Hughes DI, Barbara G, Dietrich G, Bulmer D, Cenac N. (2018) 5-oxoETE triggers nociception in constipation predominant irritable bowel syndrome through MAS-related G protein coupled receptor D. Sci. Signal. In press
Desormeaux C, Bautzova T, Garcia-Caraballo S, Rolland C, Barbaro MR, Brierley SM, Barbara G, Vergnolle N, Cenac N. (2018) Protease-activated receptor 1 is implicated in irritable bowel syndrome mediators-induced signaling to thoracic human sensory neurons. Pain. 159(7):1257-1267.
Abot A, Lucas A, Bautzova T, Bessac A, Fournel A, Le-Gonidec S, Valet P, Moro C, Cani PD, Knauf C. (2018) Galanin enhances systemic glucose metabolism through enteric Nitric Oxide Synthase-expressed neurons. Mol Metab. 10:100-108.
Basso L, Boué J, Augé C, Deraison C, Blanpied C, Cenac N, Lluel P, Vergnolle N, Dietrich G. (2018) Mobilization of CD4+ T lymphocytes in inflamed mucosa reduces pain in colitis mice: toward a vaccinal strategy to alleviate inflammatory visceral pain. Pain. 159(2):331-341.
Basso L, Garnier L, Bessac A, Boué J, Blanpied C, Cenac N, Laffont S, Dietrich G. (2018) T-lymphocyte-derived enkephalins reduce Th1/Th17 colitis and associated pain in mice.
J Gastroenterol. 53(2):215-226.
Bessac A, Cani PD, Meunier E, Dietrich G, Knauf C. (2018) Inflammation and Gut-Brain Axis During Type 2 Diabetes: Focus on the Crosstalk Between Intestinal Immune Cells and Enteric Nervous System. Front Neurosci. 12:725.
Abot A, Cani PD, Knauf C. (2018) Impact of Intestinal Peptides on the Enteric Nervous System: Novel Approaches to Control Glucose Metabolism and Food Intake. Front Endocrinol. 9:328.
Rezg R, Abot A, Mornagui B, Aydi S, Knauf C. (2018) Effects of Bisphenol S on hypothalamic neuropeptides regulating feeding behavior and apelin/APJ system in mice. Ecotoxicol Environ Saf. 161:459-466.
Guivarc'h E, Buscato M, Guihot AL, Favre J, Vessières E, Grimaud L, Wakim J, Melhem NJ, Zahreddine R, Adlanmerini M, Loufrani L, Knauf C, Katzenellenbogen JA, Katzenellenbogen BS, Foidart JM, Gourdy P, Lenfant F, Arnal JF, Henrion D, Fontaine C. (2018) Predominant Role of Nuclear Versus Membrane Estrogen Receptor α in Arterial Protection: Implications for Estrogen Receptor α Modulation in Cardiovascular Prevention/Safety. J Am Heart Assoc. 7(13).
Rastelli M, Knauf C, Cani PD. (2018) Gut Microbes and Health: A Focus on the Mechanisms Linking Microbes, Obesity, and Related Disorders. Obesity. 26(5):792-800.
2017
Pérez-Berezo T, Pujo J, Martin P, Le Faouder P, Galano JM, Guy A, Knauf C, Tabet JC, Tronnet S, Barreau F, Heuillet M, Dietrich G, Bertrand-Michel J, Durand T, Oswald E, Cenac N. (2017) Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917. Nat Commun. 8(1):1314.
Fournel A, Drougard A, Duparc T, Marlin A, Brierley SM, Castro J, Le-Gonidec S, Masri B, Colom A, Lucas A, Rousset P, Cenac N, Vergnolle N, Valet P, Cani PD, Knauf C. (2017) Apelin targets gut contraction to control glucose metabolism via the brain. Gut. 66(2):258-269.
Reiss D, Ceredig RA, Secher T, Boue J, Barreau F, Dietrich G, Gavériaux-Ruff C. (2017) Mu and delta opioid receptor knockout mice show increased colonic sensitivity. Eur J. Pain. 21:623-634.
Al Nabhani Z, Dietrich G, Hugot JP, Barreau F. (2017) Nod2: the intestinal gate keeper. PLoS Pathog. 13(3):e1006177
Alessi MC, Cenac N, Si-Tahar M, Riteau B. (2017) FPR2: A Novel Promising Target for the Treatment of Influenza. Front Microbiol. 8:1719.
Bonnart C, Feuillet G, Vasseur V, Cenac N, Vergnolle N, Blanchard N. (2017) Protease-activated receptor 2 contributes to Toxoplasma gondii-mediated gut inflammation. Parasite Immunol. 39(11).
Bashashati M, Fichna J, Piscitelli F, Capasso R, Izzo AA, Sibaev A, Timmermans JP, Cenac N, Vergnolle N, Di Marzo V, Storr M. (2017) Targeting fatty acid amide hydrolase and transient receptor potential vanilloid-1 simultaneously to modulate colonic motility and visceral sensation in the mouse: A pharmacological intervention with N-arachidonoyl-serotonin (AA-5-HT). Neurogastroenterol Motil. 29(12).
Rolland-Fourcade C, Denadai-Souza A, Cirillo C, Lopez C, Jaramillo JO, Desormeaux C, Cenac N, Motta JP, Larauche M, Taché Y, Berghe PV, Neunlist M, Coron E, Kirzin S, Portier G, Bonnet D, Alric L, Vanner S, Deraison C, Vergnolle N. (2017) Epithelial expression and function of trypsin-3 in irritable bowel syndrome. Gut. 66(10):1767-1778.
Casemayou A, Fournel A, Bagattin A, Schanstra J, Belliere J, Decramer S, Marsal D, Gillet M, Chassaing N, Huart A, Pontoglio M, Knauf C, Bascands JL, Chauveau D, Faguer S. (2017) Hepatocyte Nuclear Factor-1β Controls Mitochondrial Respiration in Renal Tubular Cells. J Am Soc Nephrol. 28(11):3205-3217.
Ramírez S, Gómez-Valadés AG, Schneeberger M, Varela L, Haddad-Tóvolli R, Altirriba J, Noguera E, Drougard A, Flores-Martínez Á, Imbernón M, Chivite I, Pozo M, Vidal-Itriago A, Garcia A, Cervantes S, Gasa R, Nogueiras R, Gama-Pérez P, Garcia-Roves PM, Cano DA, Knauf C, Servitja JM, Horvath TL, Gomis R, Zorzano A, Claret M. (2017) Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control. Cell Metab. 25(6):1390-1399.
Nicolas S, Blasco-Baque V, Fournel A, Gilleron J, Klopp P, Waget A, Ceppo F, Marlin A, Padmanabhan R, Iacovoni JS, Tercé F, Cani PD, Tanti JF, Burcelin R, Knauf C, Cormont M, Serino M. (2017) Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism. Mol Syst Biol. 13(3):921.
Lecoutre S, Marousez L, Drougard A, Knauf C, Guinez C, Eberlé D, Laborie C, Vieau D, Lesage J, Breton C. (2017) Maternal undernutrition programs the apelinergic system of adipose tissue in adult male rat offspring. J Dev Orig Health Dis. 8(1):3-7.
Dietrich G, Barreau F. (2017) Le microbiote : un acteur décisif dans le syndrome de l’intestin irritable ? mt Pédiatrie. 20 :203-212.
2016
Cani PD, Knauf C. (2016) How gut microbes talk to organs: The role of endocrine and nervous routes. Mol Metab.5(9):743-52.
Drougard A, Fournel A, Marlin A, Meunier E, Abot A, Bautzova T, Duparc T, Louche K, Batut A, Lucas A, Le-Gonidec S, Lesage J, Fioramonti X, Moro C, Valet P, Cani PD, Knauf C. Central chronic apelin infusion decreases energy expenditure and thermogenesis in mice. (2016) Sci Rep. 23;6:31849.
Fournel A, Marlin A, Abot A, Pasquio C, Cirillo C, Cani PD, Knauf C. (2016) Glucosensing in the gastrointestinal tract: Impact on glucose metabolism. Am J Physiol Gastrointest Liver Physiol. 310(9):G645-58.
Basso L, Boue J, Mahiddine K, Blanpied C, Robiou-du-Pont S, Vergnolle N, Deraison C, Dietrich G. (2016) Endogenous analgesia mediated by CD4+ T lymphocytes is dependent on enkephalins in mice. J. Neuro. Inflamm. 13:132.
Cenac N, Castro M, Desormeaux C, Colin P, Sie M, Ranger M, Vergnolle N. (2016) A novel orally administered trimebutine compound (GIC-1001) is anti-nociceptive and features peripheral opioid agonistic activity and Hydrogen Sulphide-releasing capacity in mice. Eur J Pain. 20(5):723-30.
Gaudenzio N, Sibilano R, Marichal T, Starkl P, Reber LL, Cenac N, McNeil BD, Dong X, Hernandez JD, Sagi-Eisenberg R, Hammel I, Roers A, Valitutti S, Tsai M, Espinosa E, Galli SJ. (2016) Different activation signals induce distinct mast cell degranulation strategies.
J Clin Invest. 126(10):3981-3998.
Viola JR, Lemnitzer P, Jansen Y, Csaba G, Winter C, Neideck C, Silvestre-Roig C, Dittmar G, Döring Y, Drechsler M, Weber C, Zimmer R, Cenac N, Soehnlein O. (2016) Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice. Circ Res. 119(9):1030-1038.
Henry CO, Dalloneau E, Pérez-Berezo MT, Plata C, Wu Y, Guillon A, Morello E, Aimar RF, Potier-Cartereau M, Esnard F, Coraux C, Börnchen C, Kiefmann R, Vandier C, Touqui L, Valverde MA, Cenac N, Si-Tahar M. (2016) In vitro and in vivo evidence for an inflammatory role of the calcium channel TRPV4 in lung epithelium: Potential involvement in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol. 311(3):L664-75.
Nasri I, Bonnet D, Zwarycz B, d'Aldebert E, Khou S, Mezghani-Jarraya R, Quaranta M, Rolland C, Bonnart C, Mas E, Ferrand A, Cenac N, Magness S, Van Landeghem L, Vergnolle N, Racaud-Sultan C. (2016) PAR2-dependent activation of GSK3β regulates the survival of colon stem/progenitor cells. Am J Physiol Gastrointest Liver Physiol. 311(2):G221-36.
Coquenlorge S, Van Landeghem L, Jaulin J, Cenac N, Vergnolle N, Duchalais E, Neunlist M, Rolli-Derkinderen M. (2016) The arachidonic acid metabolite 11β-ProstaglandinF2α controls intestinal epithelial healing: deficiency in patients with Crohn's disease. Sci Rep. 6:25203.
Rolland M, Li X, Sellier Y, Martin H, Perez-Berezo T, Rauwel B, Benchoua A, Bessières B, Aziza J, Cenac N, Luo M, Casper C, Peschanski M, Gonzalez-Dunia D, Leruez-Ville M, Davrinche C, Chavanas S. (2016) PPARγ Is Activated during Congenital Cytomegalovirus Infection and Inhibits Neuronogenesis from Human Neural Stem Cells. PLoS Pathog. 12(4):e1005547.
Tcherniuk S, Cenac N, Comte M, Frouard J, Errazuriz-Cerda E, Galabov A, Morange PE, Vergnolle N, Si-Tahar M, Alessi MC, Riteau B. (2016) Formyl Peptide Receptor 2 Plays a Deleterious Role During Influenza A Virus Infections. J Infect Dis. 214(2):237-47.
Pochard C, Coquenlorge S, Jaulin J, Cenac N, Vergnolle N, Meurette G, Freyssinet M, Neunlist M, Rolli-Derkinderen M. (2016) Defects in 15-HETE Production and Control of Epithelial Permeability by Human Enteric Glial Cells From Patients With Crohn's Disease. Gastroenterology. 150(1):168-80.
Hanssens S, Marx-Deseure A, Lecoutre S, Butruille L, Fournel A, Knauf C, Besengez C, Breton C, Storme L, Deruelle P, Lesage J. (2016) Maternal obesity alters the apelinergic system at the feto-maternal interface. Placenta. 39:41-4.
Mayeur S, Wattez JS, Lukaszewski MA, Lecoutre S, Butruille L, Drougard A, Eberlé D, Bastide B, Laborie C, Storme L, Knauf C, Vieau D, Breton C, Lesage J. (2016) Apelin Controls Fetal and Neonatal Glucose Homeostasis and Is Altered by Maternal Undernutrition. Diabetes. 65(3):554-60.
2015
Cenac N, Bautzova T, Le Faouder P, Veldhuis NA, Poole DP, Rolland C, Bertrand J, Liedtke W, Dubourdeau M, Bertrand-Michel J, Zecchi L, Stanghellini V, Bunnett NW, Barbara G, Vergnolle N. (2015) Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome. Gastroenterology. 149(2):433-44.e7.
Gobbetti T, Ducheix S, le Faouder P, Perez T, Riols F, Boue J, Bertrand-Michel J, Dubourdeau M, Guillou H, Perretti M, Vergnolle N, Cenac N. (2015) Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor. Br J Pharmacol. 172(3):910-23.
Drougard A, Fournel A, Valet P, Knauf C. (2015) Impact of hypothalamic reactive oxygen species in the regulation of energy metabolism and food intake. Front Neurosci. 9:56.
Basso L, Bourreille A, Dietrich G. (2015) Intestinal inflammation and pain management. Curr. Opin. Pharmacol. 25:50-55.
Federici Canova D, Pavlov AM, Norling LV, Gobbetti T, Brunelleschi S, Le Fauder P, Cenac N, Sukhorukov GB, Perretti M. (2015) Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response. J Control Release. 217:284-92.
Leghmar K, Cenac N, Rolland M, Martin H, Rauwel B, Bertrand-Michel J, Le Faouder P, Bénard M, Casper C, Davrinche C, Fournier T, Chavanas S. (2015) Cytomegalovirus Infection Triggers the Secretion of the PPARγ Agonists 15-Hydroxyeicosatetraenoic Acid (15-HETE) and 13-Hydroxyoctadecadienoic Acid (13-HODE) in Human Cytotrophoblasts and Placental Cultures. PLoS One. 10(7):e0132627.
Boal F, Roumegoux J, Alfarano C, Timotin A, Calise D, Anesia R, Drougard A, Knauf C, Lagente C, Roncalli J, Desmoulin F, Tronchere H, Valet P, Parini A, Kunduzova O. (2015) Apelin regulates FoxO3 translocation to mediate cardioprotective responses to myocardial injury and obesity. Sci Rep. 5:16104.
Chaves-Almagro C, Castan-Laurell I, Dray C, Knauf C, Valet P, Masri B. (2015) Apelin receptors: From signaling to antidiabetic strategy. Eur J Pharmacol. 763(Pt B):149-59.
Masri B, Dray C, Knauf C, Valet P, Castan-Laurell I. (2015) The APJ receptor: a new therapeutic approach in diabetic treatment. Med Sci (Paris). 31(3):275-81.
Lapointe T, Basso L, Iftinca M, Flynn R, Chapman K, Dietrich G, Vergnolle N, Altier C. (2015) TRPV1 sensitization mediates post-inflammatory visceral pain following acute colitis. American Journal of Physiology - Gastrointestinal and Liver Physiology. 309:G87-G99.
2014
Boue J, Basso L, Cenac N, Blanpied C, Rolli-Derkinderen M, Neunlist M, Vergnolle N, Dietrich G. (2014) Endogenous regulation of visceral pain via production of opioids by colitogenic CD4(+) T cells in mice. Gastroenterology. 146(1):166-75.
Drougard A, Duparc T, Brenachot X, Carneiro L, Gouazé A, Fournel A, Geurts L, Cadoudal T, Prats AC, Pénicaud L, Vieau D, Lesage J, Leloup C, Benani A, Cani PD, Valet P, Knauf C. (2014) Hypothalamic apelin/reactive oxygen species signaling controls hepatic glucose metabolism in the onset of diabetes. Antioxid Redox Signal. 20(4):557-73.
Basso L, Boue J, Bourreille A, Dietrich G. (2014) Endogenous regulation of inflammatory pain by T cell-derived opioids: when friend turns to foe. Inflamm. Bowel Dis. 20:1870-1977.
Gobbetti T, Coldewey SM, Chen J, McArthur S, le Faouder P, Cenac N, Flower RJ, Thiemermann C, Perretti M. (2014) Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. Proc Natl Acad Sci U S A. 111(52):18685-90.
Fichna J, Sobczak M, Mokrowiecka A, Cygankiewicz AI, Zakrzewski PK, Cenac N, Sałaga M, Timmermans JP, Vergnolle N, Małecka-Panas E, Krajewska WM, Storr M. (2014) Activation of the endogenous nociceptin system by selective nociceptin receptor agonist SCH 221510 produces antitransit and antinociceptive effect: a novel strategy for treatment of diarrhea-predominant IBS. Neurogastroenterol Motil. 26(11):1539-50.
Ochoa-Cortes F, Guerrero-Alba R, Valdez-Morales EE, Spreadbury I, Barajas-Lopez C, Castro M, Bertrand J, Cenac N, Vergnolle N, Vanner SJ. (2014) Chronic stress mediators act synergistically on colonic nociceptive mouse dorsal root ganglia neurons to increase excitability. Neurogastroenterol Motil. 26(3):334-45.
Abot A, Fontaine C, Buscato M, Solinhac R, Flouriot G, Fabre A, Drougard A, Rajan S, Laine M, Milon A, Muller I, Henrion D, Adlanmerini M, Valéra MC, Gompel A, Gerard C, Péqueux C, Mestdagt M, Raymond-Letron I, Knauf C, Ferriere F, Valet P, Gourdy P, Katzenellenbogen BS, Katzenellenbogen JA, Lenfant F, Greene GL, Foidart JM, Arnal JF. (2014) The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation. EMBO Mol Med. 6(10):1328-46.
Geurts L, Neyrinck AM, Delzenne NM, Knauf C, Cani PD. Gut microbiota controls adipose tissue expansion, gut barrier and glucose metabolism: novel insights into molecular targets and interventions using prebiotics. (2014) Benef Microbes. 5(1):3-17.
