David Sagnat


    Publications

    Human fallopian tube organoids provide a favourable environment for sperm motility. Nicolas Gatimel, Guillaume Perez, ..., David Sagnat, ..., Céline Deraison, Jean‐Paul Motta, ..., Nathalie Vergnolle, Human Reproduction 2025. DOI: 10.1093/humrep/deae258

    Chymotrypsin activity signals to intestinal epithelium by protease‐activated receptor‐dependent mechanisms. Simon Guignard, Mahmoud Saifeddine, ..., Laura Guiraud, David Sagnat, ..., Anissa Edir, ..., Étienne Buscail, ..., Nathalie Vergnolle, ..., Céline Deraison, Chrystelle Bonnart, British Journal of Pharmacology 2024. DOI: 10.1111/bph.16341

    TRPV4 stimulates colonic afferents through mucosal release of ATP and glutamate. Michelle Y. Meng, Luke W Paine, David Sagnat, ..., Étienne Buscail, ..., Nathalie Vergnolle, et al., British Journal of Pharmacology 2024. DOI: 10.1111/bph.17408

    Daphnanes diterpenes from the latex of Hura crepitans L. and their PKCζ-dependent anti-proliferative activity on colorectal cancer cells. Elise Crossay, Valérie Jullian, ..., David Sagnat, ..., Étienne Buscail, ..., Céline Deraison, Claire Racaud‐Sultan, et al., Bioorganic & Medicinal Chemistry 2023. DOI: 10.1016/j.bmc.2023.117366

    Prenatal stress induces changes in PAR2- and M3-dependent regulation of colon primitive cells. Mathieu Berger, Laura Guiraud, ..., David Sagnat, ..., Nathalie Vergnolle, Céline Deraison, ..., Claire Racaud‐Sultan, American Journal of Physiology-Gastrointestinal and Liver Physiology 2022. DOI: 10.1152/ajpgi.00061.2022

    Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation. Jean‐Paul Motta, Corinne Rolland, Anissa Edir, ..., David Sagnat, Chrystelle Bonnart, Perrine Rousset, Laura Guiraud, ..., Emmanuel Mas, ..., Étienne Buscail, ..., Nathalie Vergnolle, Céline Deraison, Mucosal Immunology 2021. DOI: 10.1038/s41385-021-00375-w

    Increased Mucosal Thrombin is Associated with Crohn’s Disease and Causes Inflammatory Damage through Protease-activated Receptors Activation. Jean‐Paul Motta, Simone Palese, ..., Perrine Rousset, David Sagnat, Laura Guiraud, Anissa Edir, Carine Séguy, ..., Éric Oswald, ..., Céline Deraison, Nathalie Vergnolle, Journal of Crohn's and Colitis 2020. DOI: 10.1093/ecco-jcc/jjaa229

    Active thrombin produced by the intestinal epithelium controls mucosal biofilms. Jean‐Paul Motta, Alexandre Denadai‐Souza, David Sagnat, Laura Guiraud, Anissa Edir, Chrystelle Bonnart, ..., Perrine Rousset, ..., Carine Séguy, ..., Éric Oswald, ..., Céline Deraison, Nathalie Vergnolle, Nature Communications 2019. DOI: 10.1038/s41467-019-11140-w

    Sexual dimorphism in PAR2-dependent regulation of primitive colonic cells. Julie Noguerol, Pierre-Jean Roustan, ..., Laura Guiraud, David Sagnat, Anissa Edir, Chrystelle Bonnart, ..., Céline Deraison, Nathalie Vergnolle, Claire Racaud‐Sultan, Biology of Sex Differences 2019. DOI: 10.1186/s13293-019-0262-6