High thrombin activity associated with crohn’s disease induces microbiota pathogenicity contributing to mucosal inflammation. Guillaume Le Cosquer, Melissa Pannier, ..., Laura Guiraud, ..., Perrine Rousset, ..., Céline Deraison, Nathalie Vergnolle, Jean‐Paul Motta, Gut Microbes 2026. DOI: 10.1080/19490976.2026.2687903

Human fallopian tube organoids provide a favourable environment for sperm motility. Nicolas Gatimel, Guillaume Perez, ..., David Sagnat, ..., Céline Deraison, Jean‐Paul Motta, ..., Nathalie Vergnolle, Human Reproduction 2025. DOI: 10.1093/humrep/deae258

A Toxic Friend: Genotoxic and Mutagenic Activity of the Probiotic Strain Escherichia coli Nissle 1917. Jean‐Philippe Nougayrède, Camille V. Chagneau, Jean‐Paul Motta, Nadège Bossuet‐Greif, ..., Frédéric E. Taieb, ..., Éric Oswald, mSphere 2021. DOI: 10.1128/msphere.00624-21

Uropathogenic E. coli induces DNA damage in the bladder. Camille V. Chagneau, Clémence Massip, Nadège Bossuet‐Greif, ..., Jean‐Paul Motta, ..., Marie‐Paule Roth, Hélène Coppin, ..., Jean‐Philippe Nougayrède, Éric Oswald, PLOS Pathogens 2021. DOI: 10.1371/journal.ppat.1009310

Effects of Hydrogen Sulfide on the Microbiome: From Toxicity to Therapy. André G. Buret, Thibault Allain, Jean‐Paul Motta, et al., Antioxidants & Redox Signaling 2021. DOI: 10.1089/ars.2021.0004

Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation. Jean‐Paul Motta, Corinne Rolland, Anissa Edir, ..., David Sagnat, Chrystelle Bonnart, Perrine Rousset, Laura Guiraud, ..., Emmanuel Mas, ..., Nathalie Vergnolle, Céline Deraison, Mucosal Immunology 2021. DOI: 10.1038/s41385-021-00375-w

Increased Mucosal Thrombin is Associated with Crohn’s Disease and Causes Inflammatory Damage through Protease-activated Receptors Activation. Jean‐Paul Motta, Simone Palese, ..., Perrine Rousset, David Sagnat, Laura Guiraud, Anissa Edir, Carine Séguy, ..., Éric Oswald, ..., Céline Deraison, Nathalie Vergnolle, Journal of Crohn's and Colitis 2020. DOI: 10.1093/ecco-jcc/jjaa229

Active thrombin produced by the intestinal epithelium controls mucosal biofilms. Jean‐Paul Motta, Alexandre Denadai‐Souza, David Sagnat, Laura Guiraud, Anissa Edir, Chrystelle Bonnart, ..., Perrine Rousset, ..., Carine Séguy, ..., Éric Oswald, ..., Céline Deraison, Nathalie Vergnolle, Nature Communications 2019. DOI: 10.1038/s41467-019-11140-w

Giardia duodenalis induces pathogenic dysbiosis of human intestinal microbiota biofilms. Jennifer Beatty, Sarah V. Akierman, Jean‐Paul Motta, et al., International Journal for Parasitology 2017. DOI: 10.1016/j.ijpara.2016.11.010

Epithelial expression and function of trypsin-3 in irritable bowel syndrome. Claire Rolland-Fourcade, Alexandre Denadai‐Souza, ..., Jean‐Paul Motta, ..., Céline Deraison, Nathalie Vergnolle, Gut 2017. DOI: 10.1136/gutjnl-2016-312094