High thrombin activity associated with crohn’s disease induces microbiota pathogenicity contributing to mucosal inflammation. Guillaume Le Cosquer, Melissa Pannier, ..., Laura Guiraud, ..., Perrine Rousset, ..., Étienne Buscail, ..., Céline Deraison, Nathalie Vergnolle, Jean‐Paul Motta, Gut Microbes 2026. DOI: 10.1080/19490976.2026.2687903

Human fallopian tube organoids provide a favourable environment for sperm motility. Nicolas Gatimel, Guillaume Perez, ..., David Sagnat, ..., Céline Deraison, Jean‐Paul Motta, ..., Nathalie Vergnolle, Human Reproduction 2025. DOI: 10.1093/humrep/deae258

Modeling Postoperative Pathologic Ileus in Mice: A Simplified and Translational Approach. Romain Gauthier, Julie Thevenin, ..., Perrine Rousset, ..., Astrid Canivet, ..., Nathalie Vergnolle, Étienne Buscail, Céline Deraison, Neurogastroenterology & Motility 2025. DOI: 10.1111/nmo.70157

Bispecific nanobody® as a new pharmacological drug for the selective inhibition of Trypsin‐3. Mélissa David, Anaïs Faihy, ..., Anissa Edir, Astrid Canivet, ..., Nathalie Vergnolle, ..., Céline Deraison, British Journal of Pharmacology 2025. DOI: 10.1111/bph.70100

Human colonic organoids for understanding early events of familial adenomatous polyposis pathogenesis. Nolwenn Laborde, Alexandre Barusseaud, ..., Anne Laure Breton, Nathalie Vergnolle, ..., Frédérick Barreau, Claire Racaud‐Sultan, Emmanuel Mas, The Journal of Pathology 2024. DOI: 10.1002/path.6366

Chymotrypsin activity signals to intestinal epithelium by protease‐activated receptor‐dependent mechanisms. Simon Guignard, Mahmoud Saifeddine, ..., Laura Guiraud, David Sagnat, ..., Anissa Edir, ..., Étienne Buscail, ..., Nathalie Vergnolle, ..., Céline Deraison, Chrystelle Bonnart, British Journal of Pharmacology 2024. DOI: 10.1111/bph.16341

TRPV4 stimulates colonic afferents through mucosal release of ATP and glutamate. Michelle Y. Meng, Luke W Paine, David Sagnat, ..., Étienne Buscail, ..., Nathalie Vergnolle, et al., British Journal of Pharmacology 2024. DOI: 10.1111/bph.17408

Intestinal organoids to model Salmonella infection and its impact on progenitors. Yan Jin, Claire Racaud‐Sultan, ..., Anissa Edir, ..., Nathalie Vergnolle, Agnès Wiedemann, Scientific Reports 2024. DOI: 10.1038/s41598-024-65485-4

S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis. Liwen Deng, Flavia G. Costa, ..., Céline Deraison, ..., Nathalie Vergnolle, et al., Cell 2023. DOI: 10.1016/j.cell.2023.10.019

Postoperative ileus after digestive surgery: Network meta‐analysis of pharmacological intervention. Étienne Buscail, Thibault Planchamp, ..., Jean‐Paul Motta, Nathalie Vergnolle, Céline Deraison, et al., British Journal of Clinical Pharmacology 2023. DOI: 10.1111/bcp.15878

Prenatal stress induces changes in PAR2- and M3-dependent regulation of colon primitive cells. Mathieu Berger, Laura Guiraud, ..., David Sagnat, ..., Nathalie Vergnolle, Céline Deraison, ..., Claire Racaud‐Sultan, American Journal of Physiology-Gastrointestinal and Liver Physiology 2022. DOI: 10.1152/ajpgi.00061.2022

Elafin and its precursor trappin‐2: What is their therapeutic potential for intestinal diseases?. Céline Deraison, Chrystelle Bonnart, ..., Nathalie Vergnolle, British Journal of Pharmacology 2022. DOI: 10.1111/bph.15985

Colitis Linked to Endoplasmic Reticulum Stress Induces Trypsin Activity Affecting Epithelial Functions. Núria Solà Tapias, Alexandre Denadai‐Souza, ..., Anissa Edir, ..., Emmanuel Mas, ..., Céline Deraison, Chrystelle Bonnart, Nathalie Vergnolle, Frédérick Barreau, Journal of Crohn's and Colitis 2021. DOI: 10.1093/ecco-jcc/jjab035

Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation. Jean‐Paul Motta, Corinne Rolland, Anissa Edir, ..., David Sagnat, Chrystelle Bonnart, Perrine Rousset, Laura Guiraud, ..., Emmanuel Mas, ..., Étienne Buscail, ..., Nathalie Vergnolle, Céline Deraison, Mucosal Immunology 2021. DOI: 10.1038/s41385-021-00375-w

GSK3β, a Master Kinase in the Regulation of Adult Stem Cell Behavior. Claire Racaud‐Sultan, Nathalie Vergnolle, Cells 2021. DOI: 10.3390/cells10020225

Characterization of Human Colon Organoids From Inflammatory Bowel Disease Patients. Emilie d'Aldebert, Muriel Quaranta, ..., Claire Racaud‐Sultan, Emmanuel Mas, Céline Deraison, Nathalie Vergnolle, Frontiers in Cell and Developmental Biology 2020. DOI: 10.3389/fcell.2020.00363

The Interplay Between Genetic Risk Factors and Proteolytic Dysregulation in the Pathophysiology of Inflammatory Bowel Disease. Núria Solà-Tapias, Nathalie Vergnolle, ..., Frédérick Barreau, Journal of Crohn's and Colitis 2020. DOI: 10.1093/ecco-jcc/jjaa033

Increased Mucosal Thrombin is Associated with Crohn’s Disease and Causes Inflammatory Damage through Protease-activated Receptors Activation. Jean‐Paul Motta, Simone Palese, ..., Perrine Rousset, David Sagnat, Laura Guiraud, Anissa Edir, Carine Séguy, ..., Éric Oswald, ..., Céline Deraison, Nathalie Vergnolle, Journal of Crohn's and Colitis 2020. DOI: 10.1093/ecco-jcc/jjaa229

Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2. Alberto Caminero, Justin L. McCarville, ..., Céline Deraison, ..., Nathalie Vergnolle, et al., Nature Communications 2019. DOI: 10.1038/s41467-019-09037-9

Active thrombin produced by the intestinal epithelium controls mucosal biofilms. Jean‐Paul Motta, Alexandre Denadai‐Souza, David Sagnat, Laura Guiraud, Anissa Edir, Chrystelle Bonnart, ..., Perrine Rousset, ..., Carine Séguy, ..., Éric Oswald, ..., Céline Deraison, Nathalie Vergnolle, Nature Communications 2019. DOI: 10.1038/s41467-019-11140-w

Sexual dimorphism in PAR2-dependent regulation of primitive colonic cells. Julie Noguerol, Pierre-Jean Roustan, ..., Laura Guiraud, David Sagnat, Anissa Edir, Chrystelle Bonnart, ..., Céline Deraison, Nathalie Vergnolle, Claire Racaud‐Sultan, Biology of Sex Differences 2019. DOI: 10.1186/s13293-019-0262-6

Protectin D1 n-3 DPA and resolvin D5 n-3 DPA are effectors of intestinal protection. Thomas Gobbetti, Jesmond Dalli, ..., Nathalie Vergnolle, Céline Deraison, et al., Proceedings of the National Academy of Sciences 2017. DOI: 10.1073/pnas.1617290114

Epithelial expression and function of trypsin-3 in irritable bowel syndrome. Claire Rolland-Fourcade, Alexandre Denadai‐Souza, ..., Jean‐Paul Motta, ..., Céline Deraison, Nathalie Vergnolle, Gut 2017. DOI: 10.1136/gutjnl-2016-312094

Apelin targets gut contraction to control glucose metabolism via the brain. Audren Fournel, Anne Drougard, ..., Perrine Rousset, ..., Nathalie Vergnolle, et al., Gut 2015. DOI: 10.1136/gutjnl-2015-310230