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CONTACTS
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EQUIPE 1 :SIGNAUX PROTÉOLYTIQUES DE L'INTESTIN
TEAM 1 : GUT PROTEASE SIGNALS |
Mini CV
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mots cles KeywordsBiofilms et microbiote intestinal, Thrombine, Maladies Inflammatoires Chroniques de l'Intestin, Inflammation, Cellules Epitheliales, Protéases/Antiprotéases , Infections à entéropathogènes
Biofilms and intestinal microbiota, Thrombin, Inflammatory Bowel Diseases, Inflammation, Intestinal Epithelial Cells, Proteases/ Antiproteases, Enteropathogen infections |
Recherche/projet research/project
Mes recherches portent sur l'étude des facteurs de l'hôte impliqués dans la réponse aux communautés microbiennes qui vivent en biofilms à la surface de la muqueuse intestinale. Je cherche à comprendre comment une mauvaise régulation de ces facteurs peut modifier de façon délétère les biofilms microbiens, et contribuer à la physiopathologie de maladies digestives inflammatoires et infectieuses. Ces recherches visent aussi à développer des stratégies pour restaurer l'équilibre hôte/biofilm dans l'intestin, et d'offrir de nouvelles pistes thérapeutiques pour le traitement de patients atteints de maladies digestives.
My research interest broadly relates to host and microbial biofilms interactions in the gut. I am studying how dysregulation in the production of host factors (for instance, epithelial proteases) leads to biofilm alterations, and participate in the pathophysiology of inflammatory and infectious intestinal diseases. Importantly, I am evaluating strategies to restore homeostatic epithelium/biofilm crosstalk with the hope of gaining insights for future treatment options for diseases affecting intestinal tissues.
My research interest broadly relates to host and microbial biofilms interactions in the gut. I am studying how dysregulation in the production of host factors (for instance, epithelial proteases) leads to biofilm alterations, and participate in the pathophysiology of inflammatory and infectious intestinal diseases. Importantly, I am evaluating strategies to restore homeostatic epithelium/biofilm crosstalk with the hope of gaining insights for future treatment options for diseases affecting intestinal tissues.
Production scientifique scientific production
RESEAUX SOCIAUX Social network
https://orcid.org/0000-0002-9464-0695
https://orcid.org/0000-0002-9464-0695
Sélection de publications: Selected publication
- Gastrointestinal biofilms in health and disease.
Motta JP, Wallace JL, Buret AG, Deraison C, Vergnolle N.Nat Rev Gastroenterol Hepatol. 2021 Jan 28. doi: 10.1038/s41575-020-00397-y. Online ahead of print. PMID: 33510461 Review. - Increased mucosal thrombin is associated with Crohn's disease and causes inflammatory damage through Protease-Activated Receptors activation.
Motta JP, Palese S, Giorgio C, Chapman K, Denadai-Souza A, Rousset P, Sagnat D, Guiraud L, Edir A, Seguy C, Alric L, Bonnet D, Bournet B, Buscail L, Gilletta C, Buret AG, Wallace JL, Hollenberg MD, Oswald E, Barocelli E, LE Grand S, LE Grand B, Deraison C, Vergnolle N.J Crohns Colitis. 2020 Nov 17:jjaa229. doi: 10.1093/ecco-jcc/jjaa229. Online ahead of print. PMID: 33201214 - Active thrombin produced by the intestinal epithelium controls mucosal biofilms.
Motta JP, Denadai-Souza A, Sagnat D, Guiraud L, Edir A, Bonnart C, Sebbag M, Rousset P, Lapeyre A, Seguy C, Mathurine-Thomas N, Galipeau HJ, Bonnet D, Alric L, Buret AG, Wallace JL, Dufour A, Verdu EF, Hollenberg MD, Oswald E, Serino M, Deraison C, Vergnolle N.Nat Commun. 2019 Jul 19;10(1):3224. doi: 10.1038/s41467-019-11140-w. PMID: 31324782 Free PMC article. - Iron Sequestration in Microbiota Biofilms As A Novel Strategy for Treating Inflammatory Bowel Disease.
Motta JP, Allain T, Green-Harrison LE, Groves RA, Feener T, Ramay H, Beck PL, Lewis IA, Wallace JL, Buret AG.Inflamm Bowel Dis. 2018 Jun 8;24(7):1493-1502. doi: 10.1093/ibd/izy116. PMID: 29788224 Free PMC article. - Hydrogen sulfide protects from colitis and restores intestinal microbiota biofilm and mucus production.
Motta JP, Flannigan KL, Agbor TA, Beatty JK, Blackler RW, Workentine ML, Da Silva GJ, Wang R, Buret AG, Wallace JL.Inflamm Bowel Dis. 2015 May;21(5):1006-17. doi: 10.1097/MIB.0000000000000345.PMID: 25738373 - Food-grade bacteria expressing elafin protect against inflammation and restore colon homeostasis.
Motta JP, Bermúdez-Humarán LG, Deraison C, Martin L, Rolland C, Rousset P, Boue J, Dietrich G, Chapman K, Kharrat P, Vinel JP, Alric L, Mas E, Sallenave JM, Langella P, Vergnolle N.Sci Transl Med. 2012 Oct 31;4(158):158ra144. doi: 10.1126/scitranslmed.3004212.PMID: 23115353 Free article. - Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.
Motta JP, Magne L, Descamps D, Rolland C, Squarzoni-Dale C, Rousset P, Martin L, Cenac N, Balloy V, Huerre M, Fröhlich LF, Jenne D, Wartelle J, Belaaouaj A, Mas E, Vinel JP, Alric L, Chignard M, Vergnolle N, Sallenave JM.Gastroenterology. 2011 Apr;140(4):1272-82. doi: 10.1053/j.gastro.2010.12.050. Epub 2011 Jan 1.PMID: 21199654
