ASSISTANTE-INGENIEURE (AI)
INSERM
​

CONTACTS

00 33 (0)5 62 74 45 10
EQUIPE 2 : PATHOGÉNIE ET COMMENSALISME DES ENTEROBACTÉRIES
TEAM 2 : PATHOGENESIS AND COMMENSALISM OF ENTEROBACTERIA

CARREER PATH/ CARRIERE 

2017 : M2 physiopathologie, Université Paul Sabatier, Toulouse. M2 internship – Study of the effects of an immunomodulatory phosphorus dendrimer targeting microglia in neuroinflammatory processes, INSERM – Centre de Physiopathologie de Toulouse Purpan.
 
2017 October – 2019 September : Project engineer on a project financed by a private company (Toulouse Tech Transfert) – Study of the therapeutic targeting of reactive microgliosis by a phosphorus dendrimer for the treatment of Parkinson’s disease, INSERM – Centre de Physiopathologie de Toulouse Purpan.

research/project

ENTEROBACTERIAL INFECTIONS AND DYSBIOSIS IN METABOLIC DISEASES AND GUT INFLAMMATION

ANIMAL AND CELLULAR MODELS /
TECHNICS AND METHODS

  • Cell biology : Culture of cell line and primary cells in L1 and L2 confined room, multiparametric flow cytometry, light microscopy, confocal microscopy and immunocytochemistry, isolation and cultivation of adult murin primary microglia.
  • Molecular biology : DNA/RNA extraction, quantitative PCR.
  • Animal experimentation : Restraint, intraperitoneal, intranasal and intravenous injection, organ removal, suture, microdissection under magnifying glass and small animal imaging, intracerebral injection. 
  • Animal experimentation at applicator and designer level

scientific production ​

Multivalent nanosystems: targeting monocytes/macrophages.
Poupot R, Goursat C, Fruchon S.Int J Nanomedicine. 2018 Sep 19;13:5511-5521. doi: 10.2147/IJN.S146192. eCollection 2018.PMID: 30271144 
 
Biodistribution and Biosafety of a Poly(Phosphorhydrazone) Dendrimer, an Anti-Inflammatory Drug-Candidate.
Fruchon S, Bellard E, Beton N, Goursat C, Oukhrib A, Caminade AM, Blanzat M, Turrin CO, Golzio M, Poupot R.Biomolecules. 2019 Sep 11;9(9):475. doi: 10.3390/biom9090475.PMID: 31514434