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CONTACTS
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EQUIPE 2 : PATHOGÉNIE ET COMMENSALISME DES ENTEROBACTÉRIES
TEAM 2 : PATHOGENESIS AND COMMENSALISM OF ENTEROBACTERIA |
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CARREER PATH/ CARRIERE
2017 : M2 physiopathologie, Université Paul Sabatier, Toulouse. M2 internship – Study of the effects of an immunomodulatory phosphorus dendrimer targeting microglia in neuroinflammatory processes, INSERM – Centre de Physiopathologie de Toulouse Purpan.
2017 October – 2019 September : Project engineer on a project financed by a private company (Toulouse Tech Transfert) – Study of the therapeutic targeting of reactive microgliosis by a phosphorus dendrimer for the treatment of Parkinson’s disease, INSERM – Centre de Physiopathologie de Toulouse Purpan.
2017 October – 2019 September : Project engineer on a project financed by a private company (Toulouse Tech Transfert) – Study of the therapeutic targeting of reactive microgliosis by a phosphorus dendrimer for the treatment of Parkinson’s disease, INSERM – Centre de Physiopathologie de Toulouse Purpan.
research/project
ENTEROBACTERIAL INFECTIONS AND DYSBIOSIS IN METABOLIC DISEASES AND GUT INFLAMMATION
ANIMAL AND CELLULAR MODELS /
TECHNICS AND METHODS
- Cell biology : Culture of cell line and primary cells in L1 and L2 confined room, multiparametric flow cytometry, light microscopy, confocal microscopy and immunocytochemistry, isolation and cultivation of adult murin primary microglia.
- Molecular biology : DNA/RNA extraction, quantitative PCR.
- Animal experimentation : Restraint, intraperitoneal, intranasal and intravenous injection, organ removal, suture, microdissection under magnifying glass and small animal imaging, intracerebral injection.
- Animal experimentation at applicator and designer level
scientific production
HlyF, an underestimated virulence factor of uropathogenic Escherichia coli.
Chagneau CV, Payros D, Goman A, Goursat C, David L, Okuno M, Bordignon PJ, Séguy C, Massip C, Branchu P, Ogura Y, Nougayrède JP, Marenda M, Oswald E. Clin Microbiol Infect. 2023. S1198-743X(23)00352-X.
Multivalent nanosystems: targeting monocytes/macrophages.
Poupot R, Goursat C, Fruchon S.Int J Nanomedicine. 2018 Sep 19;13:5511-5521. doi: 10.2147/IJN.S146192. eCollection 2018.PMID: 30271144
Biodistribution and Biosafety of a Poly(Phosphorhydrazone) Dendrimer, an Anti-Inflammatory Drug-Candidate.
Fruchon S, Bellard E, Beton N, Goursat C, Oukhrib A, Caminade AM, Blanzat M, Turrin CO, Golzio M, Poupot R.Biomolecules. 2019 Sep 11;9(9):475. doi: 10.3390/biom9090475.PMID: 31514434
Chagneau CV, Payros D, Goman A, Goursat C, David L, Okuno M, Bordignon PJ, Séguy C, Massip C, Branchu P, Ogura Y, Nougayrède JP, Marenda M, Oswald E. Clin Microbiol Infect. 2023. S1198-743X(23)00352-X.
Multivalent nanosystems: targeting monocytes/macrophages.
Poupot R, Goursat C, Fruchon S.Int J Nanomedicine. 2018 Sep 19;13:5511-5521. doi: 10.2147/IJN.S146192. eCollection 2018.PMID: 30271144
Biodistribution and Biosafety of a Poly(Phosphorhydrazone) Dendrimer, an Anti-Inflammatory Drug-Candidate.
Fruchon S, Bellard E, Beton N, Goursat C, Oukhrib A, Caminade AM, Blanzat M, Turrin CO, Golzio M, Poupot R.Biomolecules. 2019 Sep 11;9(9):475. doi: 10.3390/biom9090475.PMID: 31514434
