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EQUIPE 1 :SIGNAUX PROTÉOLYTIQUES DE L'INTESTIN
TEAM 1 : GUT PROTEASE SIGNALS |
Mini CV
- 2016-présent : Chercheur statutaire, INSERM Unité 1220, Institut de Recherche en Santé Digestive IRSD
- 2011-2015: Chercheur statutaire, UMR INSERM U1043/ CNRS U5282
- 2002-2010: Chercheur statutaire, INSERM Unité 563
- 1993-2002: Chercheur statutaire, INSERM Unité 326
- 2016-present : Full position researcher at INSERM Unit 1220, Institut de Recherche en Santé Digestive IRSD
- 2011-2015: Full position researcher at UMR INSERM U1043/ CNRS U5282
- 2002-2010: Full position researcher at INSERM Unit 563
- 1993-2002: Full position researcher at INSERM Unit 326
expertise
- Cellules intestinales primaires humaines et murines cultivées sous forme d’organoïde (Tri de cellules souches, co-culture avec le stroma)
- Lignées cellulaires cancéreuses cultivées sous forme de sphéroïdes
- Tissus de souris PAR2 KO
- Etudes en transduction du signal par les techniques de biochimie des protéines et des lipides
- Human and mouse primary intestinal cells cultured as organoids (Stem cell sorting, co-culture with stroma)
- Cancer cell lines cultured as spheroids
- PAR2 KO tissues
- Signal transduction studies (protein and lipid biochemistry)
Recherche/projet research/project
Cellules souches, adhésion cellulaire et transduction du signal
Les cellules souches intestinales (CSI) ont récemment été identifiées et impliquées dans les pathologies inflammatoires et cancéreuses intestinales. Notre objectif est de mieux appréhender les différents sous-types de CSI et leurs fonctions en physiologie et physiopathologie. En particulier, nous étudions la signalisation croisée entre les récepteurs d’adhésion et les autres récepteurs membranaires tels que les récepteurs de protéases inflammatoires
Stem cells, cell adhesion and signal transduction
Intestinal stem cells (ISC) have recently been identified and implicated in both inflammatory and cancer intestinal pathologies. Our aim is to get a better understanding of ISC sub-types and functions in both physiological and pathological conditions. Specially, we investigate the signaling crosstalk between adhesion receptors and other receptors such as protease-activated receptors.
Les cellules souches intestinales (CSI) ont récemment été identifiées et impliquées dans les pathologies inflammatoires et cancéreuses intestinales. Notre objectif est de mieux appréhender les différents sous-types de CSI et leurs fonctions en physiologie et physiopathologie. En particulier, nous étudions la signalisation croisée entre les récepteurs d’adhésion et les autres récepteurs membranaires tels que les récepteurs de protéases inflammatoires
Stem cells, cell adhesion and signal transduction
Intestinal stem cells (ISC) have recently been identified and implicated in both inflammatory and cancer intestinal pathologies. Our aim is to get a better understanding of ISC sub-types and functions in both physiological and pathological conditions. Specially, we investigate the signaling crosstalk between adhesion receptors and other receptors such as protease-activated receptors.
Production scientifique scientific production
1. Nasri I, Bonnet D, Zwarycz B, D’Aldebert E, Khou S, Mezghani-Jarraya R, Quaranta M, Rolland C, Bonnart C, Mas E, Ferrand A, Cenac N, Magness S, Van Landeghem L, Vergnolle N and Racaud-Sultan C. PAR2-dependent activation of GSK3b regulates the survival of colon stem/progenitor cells. Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1; 311 (2): G221-36.
2. Despeaux M, Chicanne G, Rouer E, De Toni-Costes F, Bertrand J, Mansat-De Mas V, Vergnolle N, Eaves C, Payrastre B, Girault JA and Racaud-Sultan C. Focal Adhesion Kinase Splice Variants Maintain Primitive Acute Myeloid Leukemia Cells Through Altered Wnt Signaling. Stem Cells. 2012 ; 30 :1597-610.
3. Bertrand J, Despeaux M, Joly S, Bourogaa E, Gallay N, Demur C, Bonnevialle P, Louache F, Maguer-Satta V, Vergnolle N, Payrastre B, Racaud-Sultan C. Sex differences in the GSK3b-mediated survival of adherent leukemic progenitors. Oncogene 2012 Feb 9;31(6):694-705.
4. Despeaux, M., Labat, E., Gadelorge, M., Prade, N., Bertrand, J., Demur, C., Recher, C., Bonnevialle, P., Payrastre, B., Bourin, P. and Racaud-Sultan, C. Critical features of FAK-expressing AML bone marrow microenvironment through leukemia stem cell hijacking of mesenchymal stromal cells. Leukemia 2011 Nov;25(11):1789-93.
5. De Toni-Costes, F., Despeaux, M., Bertrand, J., Bourogaa, E., Ysebaert, L., Payrastre, B., and Racaud-Sultan, C. A new a5b1 integrin-dependent survival pathway through GSK3b activation in leukemic cells. PLoS One 2010, 5, e9807
6. De Toni, F., Racaud-Sultan, C., Chicanne, G., Mansat-De Mas, V., Cariven, C., Mesange, F., Salles, J.P., Demur, C., Allouche, M., Payrastre, B., Manenti, S. and Ysebaert, L. A cross-talk between the Wnt and adhesion-dependent signaling pathways governs the chemosensitivity of acute myeloid leukemia. Oncogene 2006, 25, 3113-22.
7. Recher, C., Ysebaert, L., Beyne-Rauzy, O., Mansat-De Mas, V., Ruidavets, J. B., Cariven, P., Demur, C., Payrastre, B., Laurent, G. and Racaud-Sultan, C. Expression of focal adhesion kinase in acute myeloid leukemia is associated with enhanced blast migration, increased cellularity, and poor prognosis. Cancer Res. 2004, 64, 3191-3197.
8. Paulhe, F., Racaud-Sultan, C., Ragab, A., Albiges-Rizo, C., Chap, H., Iberg, N., Morand, O., and Perret, B. Differential regulation of phosphoinositides metabolism by avb3 and avb5 integrins upon smooth muscle cell migration. J. Biol. Chem. 2001, 276, 41832-41840.
9. Heraud, J. M., Racaud-Sultan, C., Gironcel, D., Albiges-Rizo, C., Giacomini, T., Roques, S., Martel, V., Breton-Douillon, M., Perret, B., and Chap, H. Lipid products of phosphoinositide 3-kinase and phosphatidylinositol 4,5-bisphophate are both required for ADP-dependent platelet spreading. J. Biol. Chem. 1998, 273, 17817-17823
10. Sultan, C., Plantavid, M., Bachelot, C., Grondin, P., Breton, M., Mauco, G., Lévy-Toledano, S., Caen, J. P., and Chap, H. Involvement of platelet glycoprotein IIb-IIIa (aIIbb3-integrin) in thrombin-induced synthesis of phosphatidylinositol 3,4-bisphosphate. J. Biol. Chem. 1991, 266, 23554-23557.
2. Despeaux M, Chicanne G, Rouer E, De Toni-Costes F, Bertrand J, Mansat-De Mas V, Vergnolle N, Eaves C, Payrastre B, Girault JA and Racaud-Sultan C. Focal Adhesion Kinase Splice Variants Maintain Primitive Acute Myeloid Leukemia Cells Through Altered Wnt Signaling. Stem Cells. 2012 ; 30 :1597-610.
3. Bertrand J, Despeaux M, Joly S, Bourogaa E, Gallay N, Demur C, Bonnevialle P, Louache F, Maguer-Satta V, Vergnolle N, Payrastre B, Racaud-Sultan C. Sex differences in the GSK3b-mediated survival of adherent leukemic progenitors. Oncogene 2012 Feb 9;31(6):694-705.
4. Despeaux, M., Labat, E., Gadelorge, M., Prade, N., Bertrand, J., Demur, C., Recher, C., Bonnevialle, P., Payrastre, B., Bourin, P. and Racaud-Sultan, C. Critical features of FAK-expressing AML bone marrow microenvironment through leukemia stem cell hijacking of mesenchymal stromal cells. Leukemia 2011 Nov;25(11):1789-93.
5. De Toni-Costes, F., Despeaux, M., Bertrand, J., Bourogaa, E., Ysebaert, L., Payrastre, B., and Racaud-Sultan, C. A new a5b1 integrin-dependent survival pathway through GSK3b activation in leukemic cells. PLoS One 2010, 5, e9807
6. De Toni, F., Racaud-Sultan, C., Chicanne, G., Mansat-De Mas, V., Cariven, C., Mesange, F., Salles, J.P., Demur, C., Allouche, M., Payrastre, B., Manenti, S. and Ysebaert, L. A cross-talk between the Wnt and adhesion-dependent signaling pathways governs the chemosensitivity of acute myeloid leukemia. Oncogene 2006, 25, 3113-22.
7. Recher, C., Ysebaert, L., Beyne-Rauzy, O., Mansat-De Mas, V., Ruidavets, J. B., Cariven, P., Demur, C., Payrastre, B., Laurent, G. and Racaud-Sultan, C. Expression of focal adhesion kinase in acute myeloid leukemia is associated with enhanced blast migration, increased cellularity, and poor prognosis. Cancer Res. 2004, 64, 3191-3197.
8. Paulhe, F., Racaud-Sultan, C., Ragab, A., Albiges-Rizo, C., Chap, H., Iberg, N., Morand, O., and Perret, B. Differential regulation of phosphoinositides metabolism by avb3 and avb5 integrins upon smooth muscle cell migration. J. Biol. Chem. 2001, 276, 41832-41840.
9. Heraud, J. M., Racaud-Sultan, C., Gironcel, D., Albiges-Rizo, C., Giacomini, T., Roques, S., Martel, V., Breton-Douillon, M., Perret, B., and Chap, H. Lipid products of phosphoinositide 3-kinase and phosphatidylinositol 4,5-bisphophate are both required for ADP-dependent platelet spreading. J. Biol. Chem. 1998, 273, 17817-17823
10. Sultan, C., Plantavid, M., Bachelot, C., Grondin, P., Breton, M., Mauco, G., Lévy-Toledano, S., Caen, J. P., and Chap, H. Involvement of platelet glycoprotein IIb-IIIa (aIIbb3-integrin) in thrombin-induced synthesis of phosphatidylinositol 3,4-bisphosphate. J. Biol. Chem. 1991, 266, 23554-23557.
