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EQUIPE 2 : PATHOGÉNIE ET COMMENSALISME DES ENTEROBACTÉRIES
TEAM 2 : PATHOGENESIS AND COMMENSALISM OF ENTEROBACTERIA |
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Mini CV
Dr. Oswald is a trained veterinarian (DVM). He graduated (PhD) in 1990 and worked then since 1994 at the Uniformed Services University of Health Sciences in Bethesda (USA). Until 2009, he worked as an INRA research director at the veterinary school of Toulouse (France). In 2009, he was appointed as professor at the medical faculty of the university of Toulouse. He is now professor of bacteriology at the faculty of medicine of Toulouse and hospital practitioner in the laboratory of bacteriology of the university hospital (CHU). He is an expert in cellular microbiology and molecular biology of pathogenic Escherichia coli. His main research interest is in studying toxins. His research group is working on the integration of human and animal research to decipher the thin line between commensal and pathogenic enterobacteria. Several publications generated by the team represent milestones in the understanding of bacterial pathogenicity especially discovery of new toxins.
Education and career
Education and career
- 1987 D.V.M., National Veterinary School of Toulouse, Toulouse, France
- 1987-1990 Laboratory of infectious diseases and immunology, INRA, Nouzilly, France
- 1991 Ph.D. in Microbiology, University Claude Bernard, Lyon, France
- 1991-1994 USUHS, School of Medicine, Bethesda, USA
- 1994-2010 Team leader at INRA U1225 "Host-pathogen interactions", Veterinary School
- of Toulouse, France
- 1997 Habilitation to direct research (HDR), Toulouse University, France
- 2009-2014 Deputy director of the laboratory of bacteriology at the university hospital of
- Toulouse, France
- 2009-2015 Team leader, Inserm U1043 Center for Pathophysiology of Toulouse-Purpan
- 2016-present Team leader Inserm U1220 Digestive Health Research Institute, France
- 2014-present Head of the Laboratory of bacteriology at the university hospital of Toulouse.
- 2016-present Deputy director of the Digestive Health Research Institute.
Recherche/projet research/project
RESEARCH INTERESTS:
Our goal is to use a multidisciplinary approach to understand the pathogenicity and the danger for humans and animals of different pathovars of E. coli (Enteropathogenic E. coli, Enterohemorrhagic E. coli and Extraintestinal pathogenic E. coli).
Our goal is to use a multidisciplinary approach to understand the pathogenicity and the danger for humans and animals of different pathovars of E. coli (Enteropathogenic E. coli, Enterohemorrhagic E. coli and Extraintestinal pathogenic E. coli).
Production scientifique scientific production
Selected Publications in peer-reviewed journals :
Bossuet-Greif N, Vignard J, Taieb F, Mirey G, Dubois D, Petit C, Oswald E, Nougayrède JP. The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells. MBio. 2018 Mar 20;9(2). pii: e02393-17.
Bibbal D, Um MM, Diallo AA, Kérourédan M, Dupouy V, Toutain PL, Bousquet-Mélou A, Oswald E, Brugère H. Mixing of Shiga toxin-producing and enteropathogenic Escherichia coli in a wastewater treatment plant receiving city and slaughterhouse wastewater. Int J Hyg Environ Health. 2018 Ma,. 221(2):355-363.
Pérez-Berezo T, Pujo J, Martin P, Le Faouder P, Galano JM, Guy A, Knauf C, Tabet JC, Tronnet S, Barreau F, Heuillet M, Dietrich G, Bertrand-Michel J, Durand T, Oswald E, Cenac N. Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917. Nat Commun. 2017 Nov 3;8(1):1314. doi: 10.1038/s41467-017-01403-9.
Garcie C., Tronnet S., Garénaux A., McCarthy A.J., Brachmann A.O., Pénary M, Houle S., Nougayrède J.P., Piel J., Taylor P.W., Dozois C.M., Genevaux P., Oswald E. and Martin P. The stress-responsive Hsp90 chaperone is required for the production of genotoxin and siderophore by pathogenic Escherichia coli. J Infect Dis. 2016;214(6):916-24.
Secher T, Kassem S, Benamar M, Bernard I, Boury M, Barreau F, Oswald E, Saoudi A. Oral Administration of the Probiotic Strain Escherichia coli Nissle 1917 Reduces Susceptibility to Neuroinflammation and Repairs Experimental Autoimmune Encephalomyelitis-Induced Intestinal Barrier Dysfunction.
Front Immunol. 2017 Sep 14;8:1096.
Tronnet S, Garcie C, Brachmann AO, Piel J, Oswald E, Martin P.
High iron supply inhibits the synthesis of the genotoxin colibactin by pathogenic Escherichia coli through a non-canonical Fur/RyhB-mediated pathway. Pathog Dis. 2017 Jul 31;75(5).
Martin P, Tronnet S, Garcie C, Oswald E. Interplay between siderophores and colibactin genotoxin in Escherichia coli. Life. 2017 Jun;69(6):435-441.
Tomkovich S, Yang Y, Winglee K, Gauthier J, Mühlbauer M, Sun X, Mohamadzadeh M, Liu X, Martin P, Wang GP, Oswald E, Fodor AA, Jobin C.
Locoregional effects of microbiota in a preclinical model of colon carcinogenesis. Cancer Res. 2017. Apr 17 .
Payros D, Dobrindt U, Martin P, Secher T, Bracarense AP, Boury M, Laffitte J, Pinton P, Oswald E, Oswald IP. The Food Contaminant Deoxynivalenol Exacerbates the Genotoxicity of Gut Microbiota. MBio. 2017 Mar 14;8(2).
Besson-Fournier C, Gineste A, Latour C, Gourbeyre O, Meynard D, Martin P, Oswald E, Coppin H, Roth MP. Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B. Blood. 2017 Jan 26;129(4):533-536.
Taieb F, Petit C, Nougayrède JP, Oswald E. 2016. The Enterobacterial Genotoxins: Cytolethal Distending Toxin and Colibactin. EcoSal Plus. 2016 7 (1) doi: 10.1128/ecolsalplus.ESP-0008-2016.
Secher T, Brehin C, Oswald E. 2016. Early settlers: which E. coli strains do you not want at birth? Am J Physiol Gastrointest Liver Physiol.311(1):G123-9.
Tronnet S., Garcie C., Rehms N., Dobrindt U., Oswald E., Martin P. Iron homeostasis regulates the genotoxicity of Escherichia coli producing colibactin. Infect Immun. 2016 pii: IAI.00659-16. [Epub ahead of print].
Bossuet-Greif N, Dubois D, Petit C, Tronnet S, Martin P, Bonnet R, Oswald E, Nougayrède JP. Escherichia coli ClbS is a colibactin resistance protein. Mol Microbiol. 2016 ;99(5):897-908
Um MM, Barraud O, Kérourédan M, Gaschet M, Stalder T, Oswald E, Dagot C, Ploy MC, Brugère H, Bibbal D. 2015. Comparison of the incidence of pathogenic and antibiotic-resistant Escherichia coli strains in adult cattle and veal calf slaughterhouse effluents highlighted different risks for public health. Appl Environ Microbiol. 81(4):1397-1405.
Murase K, Martin P, Porcheron G, Houle S, Helloin E, Penary M, Nougayrede JP, Dozois CM, Hayashi T, Oswald E. 2016. HlyF produced by extraintestinal pathogenic Escherichia coli is a virulence factor that regulates outer membrane vesicle biogenesis. J Infect Dis. 213:856-865.
Secher T, Payros D, Brehin C, Boury M, Watrin C, Gillet M, Bernard-Cadenat I, Menard S, Theodorou V, Saoudi A, Olier M, Oswald E. 2015 . Oral tolerance failure upon neonatal gut colonization with Escherichia coli producing the genotoxin colibactin. Infect Immun 83:2420-2429.
