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EQUIPE 2 : PATHOGÉNIE ET COMMENSALISME DES ENTEROBACTÉRIES
TEAM 2 : PATHOGENESIS AND COMMENSALISM OF ENTEROBACTERIA |
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Mini CV
Dr. Oswald is a trained veterinarian (DVM). He graduated (PhD) in 1990 and worked then since 1994 at the Uniformed Services University of Health Sciences in Bethesda (USA). Until 2009, he worked as an INRA research director at the veterinary school of Toulouse (France). In 2009, he was appointed as professor at the medical faculty of the university of Toulouse. He is now professor of bacteriology at the faculty of medicine of Toulouse and hospital practitioner in the laboratory of bacteriology of the university hospital (CHU). He is an expert in cellular microbiology and molecular biology of pathogenic Escherichia coli. His main research interest is in studying toxins. His research group is working on the integration of human and animal research to decipher the thin line between commensal and pathogenic enterobacteria. Several publications generated by the team represent milestones in the understanding of bacterial pathogenicity especially discovery of new toxins.
Education and career
Education and career
- 1987 D.V.M., National Veterinary School of Toulouse, Toulouse, France
- 1987-1990 Laboratory of infectious diseases and immunology, INRA, Nouzilly, France
- 1991 Ph.D. in Microbiology, University Claude Bernard, Lyon, France
- 1991-1994 USUHS, School of Medicine, Bethesda, USA
- 1994-2010 Team leader at INRA U1225 "Host-pathogen interactions", Veterinary School
- of Toulouse, France
- 1997 Habilitation to direct research (HDR), Toulouse University, France
- 2009-2014 Deputy director of the laboratory of bacteriology at the university hospital of
- Toulouse, France
- 2009-2015 Team leader, Inserm U1043 Center for Pathophysiology of Toulouse-Purpan
- 2016-present Team leader Inserm U1220 Digestive Health Research Institute, France
- 2014-present Head of the Laboratory of bacteriology at the university hospital of Toulouse.
- 2016-present Deputy director of the Digestive Health Research Institute.
Recherche/projet research/project
RESEARCH INTERESTS:
Our goal is to use a multidisciplinary approach to understand the pathogenicity and the danger for humans and animals of different pathovars of E. coli (Enteropathogenic E. coli, Enterohemorrhagic E. coli and Extraintestinal pathogenic E. coli).
Our goal is to use a multidisciplinary approach to understand the pathogenicity and the danger for humans and animals of different pathovars of E. coli (Enteropathogenic E. coli, Enterohemorrhagic E. coli and Extraintestinal pathogenic E. coli).
Production scientifique scientific production
Selected Publications in peer-reviewed journals :
Garcie C., Tronnet S., Garénaux A., McCarthy A.J., Brachmann A.O., Pénary M, Houle S., Nougayrède J.P., Piel J., Taylor P.W., Dozois C.M., Genevaux P., Oswald E. and Martin P. The stress-responsive Hsp90 chaperone is required for the production of genotoxin and siderophore by pathogenic Escherichia coli. J Infect Dis. 2016;214(6):916-24.
Taieb F, Petit C, Nougayrède JP, Oswald E. 2016. The Enterobacterial Genotoxins: Cytolethal Distending Toxin and Colibactin. EcoSal Plus. 2016 7 (1) doi: 10.1128/ecolsalplus.ESP-0008-2016.
Secher T, Brehin C, Oswald E. 2016. Early settlers: which E. coli strains do you not want at birth? Am J Physiol Gastrointest Liver Physiol.311(1):G123-9.
Tronnet S., Garcie C., Rehms N., Dobrindt U., Oswald E., Martin P. Iron homeostasis regulates the genotoxicity of Escherichia coli producing colibactin. Infect Immun. 2016 pii: IAI.00659-16. [Epub ahead of print].
Bossuet-Greif N, Dubois D, Petit C, Tronnet S, Martin P, Bonnet R, Oswald E, Nougayrède JP. Escherichia coli ClbS is a colibactin resistance protein. Mol Microbiol. 2016 ;99(5):897-908
Um MM, Barraud O, Kérourédan M, Gaschet M, Stalder T, Oswald E, Dagot C, Ploy MC, Brugère H, Bibbal D. 2015. Comparison of the incidence of pathogenic and antibiotic-resistant Escherichia coli strains in adult cattle and veal calf slaughterhouse effluents highlighted different risks for public health. Appl Environ Microbiol. 81(4):1397-1405.
Murase K, Martin P, Porcheron G, Houle S, Helloin E, Penary M, Nougayrede JP, Dozois CM, Hayashi T, Oswald E. 2016. HlyF produced by extraintestinal pathogenic Escherichia coli is a virulence factor that regulates outer membrane vesicle biogenesis. J Infect Dis. 213:856-865.
Secher T, Payros D, Brehin C, Boury M, Watrin C, Gillet M, Bernard-Cadenat I, Menard S, Theodorou V, Saoudi A, Olier M, Oswald E. 2015 . Oral tolerance failure upon neonatal gut colonization with Escherichia coli producing the genotoxin colibactin. Infect Immun 83:2420-2429.
Marcq I, Martin P, Payros D, Cuevas-Ramos G, Boury M, Watrin C, Nougayrede JP, Olier M, Oswald E. 2014. The genotoxin colibactin exacerbates lymphopenia and decreases survival rate in mice infected with septicemic Escherichia coli. J Infect Dis. 210:285-294.
Martin P, Marcq I, Magistro G, Penary M, Garcie C, Payros D, Boury M, Olier M, Nougayrede JP, Audebert M, Chalut C, Schubert S, Oswald E. 2013. Interplay between siderophores and colibactin genotoxin biosynthetic pathways in Escherichia coli. PLoS Pathog 9:e1003437.
Diallo AA, Brugère H, Kérourédan M, Dupouy V, Toutain PL, Bousquet-Mélou A, Oswald E, Bibbal D. 2013. Persistence and prevalence of pathogenic and extended-spectrum beta-lactamase-producing Escherichia coli in municipal wastewater treatment plant receiving slaughterhouse wastewater. Water Res. 47(13):4719-29.
Jubelin G, Taieb F, Duda DM, Hsu Y, Samba-Louaka A, Nobe R, Penary M, Watrin C, Nougayrede JP, Schulman BA, Stebbins CE, Oswald E. 2010. Pathogenic bacteria target NEDD8-conjugated cullins to hijack host-cell signaling pathways. PLoS Pathog 6(9):e1001128.
Nougayrede JP, Homburg S, Taieb F, Boury M, Brzuszkiewicz E, Gottschalk G, Buchrieser C, Hacker J, Dobrindt U, Oswald E. 2006. Escherichia coli induces DNA double-strand breaks in eukaryotic cells. Science 313:848-851.
Garcie C., Tronnet S., Garénaux A., McCarthy A.J., Brachmann A.O., Pénary M, Houle S., Nougayrède J.P., Piel J., Taylor P.W., Dozois C.M., Genevaux P., Oswald E. and Martin P. The stress-responsive Hsp90 chaperone is required for the production of genotoxin and siderophore by pathogenic Escherichia coli. J Infect Dis. 2016;214(6):916-24.
Taieb F, Petit C, Nougayrède JP, Oswald E. 2016. The Enterobacterial Genotoxins: Cytolethal Distending Toxin and Colibactin. EcoSal Plus. 2016 7 (1) doi: 10.1128/ecolsalplus.ESP-0008-2016.
Secher T, Brehin C, Oswald E. 2016. Early settlers: which E. coli strains do you not want at birth? Am J Physiol Gastrointest Liver Physiol.311(1):G123-9.
Tronnet S., Garcie C., Rehms N., Dobrindt U., Oswald E., Martin P. Iron homeostasis regulates the genotoxicity of Escherichia coli producing colibactin. Infect Immun. 2016 pii: IAI.00659-16. [Epub ahead of print].
Bossuet-Greif N, Dubois D, Petit C, Tronnet S, Martin P, Bonnet R, Oswald E, Nougayrède JP. Escherichia coli ClbS is a colibactin resistance protein. Mol Microbiol. 2016 ;99(5):897-908
Um MM, Barraud O, Kérourédan M, Gaschet M, Stalder T, Oswald E, Dagot C, Ploy MC, Brugère H, Bibbal D. 2015. Comparison of the incidence of pathogenic and antibiotic-resistant Escherichia coli strains in adult cattle and veal calf slaughterhouse effluents highlighted different risks for public health. Appl Environ Microbiol. 81(4):1397-1405.
Murase K, Martin P, Porcheron G, Houle S, Helloin E, Penary M, Nougayrede JP, Dozois CM, Hayashi T, Oswald E. 2016. HlyF produced by extraintestinal pathogenic Escherichia coli is a virulence factor that regulates outer membrane vesicle biogenesis. J Infect Dis. 213:856-865.
Secher T, Payros D, Brehin C, Boury M, Watrin C, Gillet M, Bernard-Cadenat I, Menard S, Theodorou V, Saoudi A, Olier M, Oswald E. 2015 . Oral tolerance failure upon neonatal gut colonization with Escherichia coli producing the genotoxin colibactin. Infect Immun 83:2420-2429.
Marcq I, Martin P, Payros D, Cuevas-Ramos G, Boury M, Watrin C, Nougayrede JP, Olier M, Oswald E. 2014. The genotoxin colibactin exacerbates lymphopenia and decreases survival rate in mice infected with septicemic Escherichia coli. J Infect Dis. 210:285-294.
Martin P, Marcq I, Magistro G, Penary M, Garcie C, Payros D, Boury M, Olier M, Nougayrede JP, Audebert M, Chalut C, Schubert S, Oswald E. 2013. Interplay between siderophores and colibactin genotoxin biosynthetic pathways in Escherichia coli. PLoS Pathog 9:e1003437.
Diallo AA, Brugère H, Kérourédan M, Dupouy V, Toutain PL, Bousquet-Mélou A, Oswald E, Bibbal D. 2013. Persistence and prevalence of pathogenic and extended-spectrum beta-lactamase-producing Escherichia coli in municipal wastewater treatment plant receiving slaughterhouse wastewater. Water Res. 47(13):4719-29.
Jubelin G, Taieb F, Duda DM, Hsu Y, Samba-Louaka A, Nobe R, Penary M, Watrin C, Nougayrede JP, Schulman BA, Stebbins CE, Oswald E. 2010. Pathogenic bacteria target NEDD8-conjugated cullins to hijack host-cell signaling pathways. PLoS Pathog 6(9):e1001128.
Nougayrede JP, Homburg S, Taieb F, Boury M, Brzuszkiewicz E, Gottschalk G, Buchrieser C, Hacker J, Dobrindt U, Oswald E. 2006. Escherichia coli induces DNA double-strand breaks in eukaryotic cells. Science 313:848-851.
