|
contaCt
00 33 (0)5 62 74 45 02 |
|
EQUIPE 3 : PHYSIOPATHOLOGY OF THE GUT BRAIN AXIS
Physiopathologie de l’axe intestin-cerveau |
|
Mini CV
DR2 INSERM
PhD in fundamental immunology
|
expertise |
Recherche/projet research/project
Analgesic and anti-inflammatory properties of T cell-derived opioids
Role of immune-derived opioids in intestinal homeostasis
The visceral pain resulting from inflammation-induced neuronal firing is endogenously regulated by opioids locally released by effector CD4+ T lymphocytes generated in response to microbe-derived antigens. Our objective is to better define the role of immune-derived opioids in the intestinal homeostasis including physical barrier function, mucosal immunity, and enteric nervous system activity.
Role of immune-derived opioids in intestinal homeostasis
The visceral pain resulting from inflammation-induced neuronal firing is endogenously regulated by opioids locally released by effector CD4+ T lymphocytes generated in response to microbe-derived antigens. Our objective is to better define the role of immune-derived opioids in the intestinal homeostasis including physical barrier function, mucosal immunity, and enteric nervous system activity.
Production scientifique scientific production
Basso L., J. Boue, K. Mahiddine, C. Blanpied, S. Robiou-du-Pont, N. Vergnolle, C. Deraison and G. Dietrich. 2016. Endogenous analgesia mediated by CD4+ T lymphocytes is dependent on enkephalins in mice. J. Neuro. Inflamm. 13:132.
Basso L., A. Bourreille and G. Dietrich. 2015. Intestinal inflammation and pain management. Curr. Opin. Pharmacol. 25:50-55.
Boue J., L. Basso, N. Cenac, C. Blanpied, M. Rolli-Derkinderen, M. Neunlist, N. Vergnolle and G. Dietrich. 2014. Endogenous regulation of visceral pain via opioid production by colitogenic CD4+ T lymphocytes in mice. Gastroenterology. 146: 166-175
Basso L., A. Bourreille and G. Dietrich. 2015. Intestinal inflammation and pain management. Curr. Opin. Pharmacol. 25:50-55.
Boue J., L. Basso, N. Cenac, C. Blanpied, M. Rolli-Derkinderen, M. Neunlist, N. Vergnolle and G. Dietrich. 2014. Endogenous regulation of visceral pain via opioid production by colitogenic CD4+ T lymphocytes in mice. Gastroenterology. 146: 166-175
