CHERCHEUR CR
INSERM 

CONTACTS

​00 33 (0)5 62 74 45 56

EQUIPE 1 : PHYSIOPATHOLOGIE DE L’EPITHELIUM INTESTINAL

Mini CV

  • present: CRCN INSERM
  • 2013-2020 : Postdoctoral fellow at McMaster University (Ontario, Canada, 2013), University of Calgary (Alberta, Canada, 2013-2018), IRSD (Team 1 and Team 2, 2018-2020)
  • ERC AgreenSkills Plus Fellow (2017-2019), Alberta Innovate Health Solution Fellow (2015-2018), Killam Laureate (2013-2015), Eye's High Fellow (2013-2015), CIHR-CAG Fellow (2013).

mots cles Keywords

Biofilms et microbiote intestinal, Thrombine, Maladies Inflammatoires Chroniques de l'Intestin, Inflammation, Cellules Epitheliales, Protéases/Antiprotéases , Infections à entéropathogènes
Biofilms and intestinal microbiota, Thrombin, Inflammatory Bowel Diseases, Inflammation, Intestinal Epithelial Cells, Proteases/ Antiproteases, Enteropathogen infections
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Recherche/projet  research/project

Mes recherches portent sur l'étude des facteurs de l'hôte impliqués dans la réponse aux communautés microbiennes qui vivent en biofilms à la surface de la muqueuse intestinale. Je cherche à comprendre comment une mauvaise régulation de ces facteurs peut modifier de façon délétère les biofilms microbiens, et contribuer à la physiopathologie de maladies digestives inflammatoires et infectieuses. Ces recherches visent aussi à développer des stratégies pour restaurer l'équilibre hôte/biofilm dans l'intestin, et d'offrir de nouvelles pistes thérapeutiques pour le traitement de patients atteints de maladies digestives.
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My research interest broadly relates to host and microbial biofilms interactions in the gut. I am studying how dysregulation in the production of host factors (for instance, epithelial proteases) leads to biofilm alterations, and participate in the pathophysiology of inflammatory and infectious intestinal diseases. Importantly, I am evaluating strategies to restore homeostatic epithelium/biofilm crosstalk with the hope of gaining insights for future treatment options for diseases affecting intestinal tissues.
 

Production scientifique scientific production 

RESEAUX SOCIAUX Social network 
https://orcid.org/0000-0002-9464-0695
https://loop.frontiersin.org/people/390084/overview
https://www.linkedin.com/in/jpmotta
https://www.researchgate.net/profile/Jean-Paul_MOTTA
Sélection de publications: ​Selected publication 
  • Motta, J. P., S. Palese, C. Giorgio, K. Chapman, A. Denadai-Souza, P. Rousset, D. Sagnat, L. Guiraud, A. Edir, C. Seguy, L. Alric, D. Bonnet, B. Bournet, L. Buscail, C. Gilletta, A. G. Buret, J. L. Wallace, M. D. Hollenberg, E. Oswald, E. Barocelli, L. E. G. S, L. E. G. B, C. Deraison and N. Vergnolle (2020). "Increased mucosal thrombin is associated with Crohn's disease and causes inflammatory damage through Protease-Activated Receptors activation." J Crohns Colitis
    DOI: 10.1093/ecco-jcc/jjaa229
  • Motta, J. P., A. Denadai-Souza, D. Sagnat, L. Guiraud, A. Edir, C. Bonnart, M. Sebbag, P. Rousset, A. Lapeyre, C. Seguy, N. Mathurine-Thomas, H. J. Galipeau, D. Bonnet, L. Alric, A. G. Buret, J. L. Wallace, A. Dufour, E. F. Verdu, M. D. Hollenberg, E. Oswald, M. Serino, C. Deraison and N. Vergnolle (2019). "Active thrombin produced by the intestinal epithelium controls mucosal biofilms." Nat Commun 10(1): 3224.
    DOI 10.1038/s41467-019-11140-w
  • Motta JP., Allain T, L. G-H, Groves R, T. F, H. R, Beck P, Lewis I, Wallace JL, and Buret A. "Iron Sequestration in Microbiota Biofilms As A Novel Strategy for Treating Inflammatory Bowel Disease" (2018) Inflamm Bowel Dis 24(7): 1493-1502.
    DOI: 10.1093/ibd/izy116
  • Motta, JP., K. L. Flannigan, T. A. Agbor, J. K. Beatty, R. W. Blackler, M. L. Workentine, G. J. Da Silva, R. Wang, A. G. Buret and J. L. Wallace (2015). "Hydrogen Sulfide Protects from Colitis and Restores Intestinal Microbiota Biofilm and Mucus Production." Inflammatory Bowel Diseases 21(5): 1006-1017.
  • N. Vergnolle* and P. Langella* (2015). "Serine protease inhibitors protect better than IL-10 and TGF-beta anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci." Microbial Cell Factories 14(26). doi:10.1186/s12934-015-0198-4

  • Motta, JP.*, L. G. Bermudez-Humaran*, C. Deraison, L. Martin, C. Rolland, P. Rousset, J. Boue, G. Dietrich, K. Chapman, P. Kharrat, J. P. Vinel, L. Alric, E. Mas, J. M. Sallenave, P. Langella* and N. Vergnolle* (2012). "Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis." Science Translational Medicine 4(158).
  • Motta, JP.*, L. Magne*, D. Descamps, C. Rolland, C. Squarzoni-Dale, P. Rousset, L. Martin, N. Cenac, V. Balloy, M. Huerre, L. F. Frohlich, D. Jenne, J. Wartelle, A. Belaaouaj, E. Mas, J. P. Vinel, L. Alric, M. Chignard, N. Vergnolle* and J. M. Sallenave* (2011). "Modifying the Protease, Antiprotease Pattern by Elafin Overexpression Protects Mice From Colitis." Gastroenterology 140(4): 1272-1282.
  • Motta, JP., L. Martin and N. Vergnolle (2011). Proteases/Antiproteases in Inflammatory Bowel Diseases. Proteases and Their Receptors in Inflammation., Springer Basel: 173-215.