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POST-DOCTORANT

JEAN-PAUL MOTTA

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00 33 (0)5 62 64 45 56
EQUIPE 1 : PHYSIOPATHOLOGIE DE L’EPITHELIUM INTESTINAL
TEAM 1 : PATHOPHYSIOLOGY OF THE INTESTINAL EPITHELIUM

Mini CV

  • present: Postdoctorant/ INRA AgreenSkills+ Postdoctoral fellow
  • 2013-2018: Postdoctorant/Postdoctorate fellow Killam Laureate (2013-2015)/ University of Calgary Eye's High (2013-2015) / Bourse CIHR-CAG Research Fellow (2013) / Alberta-Inovates Health-Solutions (2015-2018)
(1) Department of Biological Sciences, Faculty of Sciences, (2) Department of Pharmacology and Physiology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.

  • 2009-2012: PhD candidate, University Paul Sabatier of Toulouse, France.
Centre de Physiopathologie de l'Hopital Toulouse Purpan (CPTP), INSERM U1043, Toulouse
  • 2008-2009: Master II of Research, University Paul Sabatier of Toulouse, France Centre of Physiopathology of Toulouse Hospital Purpan (CPTP), INSERM U1043, Toulouse

Mots cles / keywords

Biofilms et microbiote intestinal, Maladies Inflammatoires Chroniques de l'Intestin, Inflammation, Cellules Epitheliales Intestinales, Protéases/Antiprotéases , Infections à entéropathogènes
 
Biofilms and intestinal microbiota, Inflammatory Bowel Diseases, Inflammation, Intestinal Epithelial Cells, Proteases/ Antiproteases, Enteropathogen infections

Recherche/projet  research/project

My research is aimed to better define the role of host and microbial proteases, released during inflammation, on the gut microbiota biofilm, their physiopathological consequences and to develop novel therapeutic approach.  
I am supported by the INRA and AgreenSkills+ European postdoctoral fellowship.  
I am hosted by two teams at the IRSD, team 1 "Physiopathology of intestinal epithelium" and team 2 "Pathogeny and commensalism of enterobacteria". 

Mon projet de recherche est destiné à mieux comprendre le rôle des protéases microbiennes et de l'hôte, libérées au cours de la réponse inflammatoire, sur le biofilm microbien intestinal, leurs conséquences physiopathologiques et découvrir de nouvelles approches thérapeutiques.  
Je suis financé par l'INRA et une bourse postdoctorale européenne AgreenSkills+.  
J'ai intégré l'IRSD au sein de deux équipes d'accueil équipe 1 " Physiopathologie de l'épithélium intestinal" et équipe 2 "Pathogénie et commensalisme des entérobactéries".

Production scientifique scientific production 

  • Motta JP., Allain T, L. G-H, Groves R, T. F, H. R, Beck P, Lewis I, Wallace JL, and Buret A. Iron Sequestration in Microbiota Biofilms As A Novel Strategy for Treating Inflammatory Bowel Disease" (2018) Inflammatory Bowel Diseases accepted 02/2018
  • Motta, JP., K. L. Flannigan, T. A. Agbor, J. K. Beatty, R. W. Blackler, M. L. Workentine, G. J. Da Silva, R. Wang, A. G. Buret and J. L. Wallace (2015). "Hydrogen Sulfide Protects from Colitis and Restores Intestinal Microbiota Biofilm and Mucus Production." Inflammatory Bowel Diseases 21(5): 1006-1017.
  • Bermudez-Humaran, L. G.*, JP. Motta*, C. Aubry, P. Kharrat, L. Rous-Martin, J. M. Sallenave, C. Deraison,
  • N. Vergnolle* and P. Langella* (2015). "Serine protease inhibitors protect better than IL-10 and TGF-beta anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci." Microbial Cell Factories 14(26). doi:10.1186/s12934-015-0198-4

  • Motta, JP.*, L. G. Bermudez-Humaran*, C. Deraison, L. Martin, C. Rolland, P. Rousset, J. Boue, G. Dietrich, K. Chapman, P. Kharrat, J. P. Vinel, L. Alric, E. Mas, J. M. Sallenave, P. Langella* and N. Vergnolle* (2012). "Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis." Science Translational Medicine 4(158).
  • Motta, JP.*, L. Magne*, D. Descamps, C. Rolland, C. Squarzoni-Dale, P. Rousset, L. Martin, N. Cenac, V. Balloy, M. Huerre, L. F. Frohlich, D. Jenne, J. Wartelle, A. Belaaouaj, E. Mas, J. P. Vinel, L. Alric, M. Chignard, N. Vergnolle* and J. M. Sallenave* (2011). "Modifying the Protease, Antiprotease Pattern by Elafin Overexpression Protects Mice From Colitis." Gastroenterology 140(4): 1272-1282.
  • Motta, JP., L. Martin and N. Vergnolle (2011). Proteases/Antiproteases in Inflammatory Bowel Diseases. Proteases and Their Receptors in Inflammation., Springer Basel: 173-215.