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EQUIPE 2 : PATHOGÉNIE ET COMMENSALISME DES ENTEROBACTÉRIES
TEAM 2 : PATHOGENESIS AND COMMENSALISM OF ENTEROBACTERIA |
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Mini CV
- Depuis Février 2011 Université Toulouse, Inserm, INRA, France
Centre de physiopathologie Toulouse-Purpan/IRSD
Equipe Commensalisme et pathogénie des Entérobactéries
Thème : Interaction hôte-pathogène, le colibacille (Escherichia coli)
Direction : Pr. Eric OSWALD.
- Décembre 2004-Octobre 2009 Université Paris Descartes, Inserm, France
Hôpital Necker Enfants Malades
Unité Pathogénie des maladies infectieuses
Thème : Interaction hôte-pathogène, le méningocoque (Neisseria meningitidis)
Direction : Pr. Xavier NASSIF. - Janvier 2001-Octobre 2004 Université Oxford, Royaume-Uni
Weatherall Institute of Molecular Medicine Department of paediatrics
Thème : Variation de phase chez la bactérie pathogène Neisseria meningitidis
Direction : Pr. E. Richard MOXON.
Recherche/projet research/project
Molecular bases of commensalism and pathogenesis of enterobacteria
Biosynthèse des facteurs de virulence chez les enterobactéries
Biosynthèse des facteurs de virulence chez les enterobactéries
Production scientifique scientific production
24 articles, deux brevets déposés
Pérez-Berezo T, Pujo J, Martin P, Le Faouder P, Galano JM, Guy A, Knauf C, Tabet JC, Tronnet S, Barreau F, Heuillet M, Dietrich G, Bertrand-Michel J, Durand T, Oswald E, Cenac N. Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917. Nat Commun. 2017 Nov 3;8(1):1314.
Delphine Payros D, Ulrich Dobrindt U, Patricia Martin, Thomas Secher, Ana Paula Bracarense, Michèle Boury, Joelle Laffitte, Philippe Pinton, Eric Oswald and Isabelle Oswald. The Food Contaminant Deoxynivalenol Exacerbates the Genotoxicity of Gut Microbiota. MBio. 2017. 8(2) pii: e00007-17 (IF 6.4)
Tronnet S, Garcie C, Brachmann AO, Piel J, Oswald E, Martin P. High iron supply inhibits the synthesis of the genotoxin colibactin by pathogenic Escherichia coli through a non-canonical Fur/RyhB-mediated pathway. Pathog Dis. 2017 Jul 31;75(5).
Sarah Tomkovich, Ye Yang, Kathryn Winglee, Josee Gauthier, Marcus Mühlbauer, Xiaolun Sun, Mansour Mohamadzadeh, Xiuli Liu, Patricia Martin, Gary P. Wang, Eric Oswald, Anthony A. Fodor, Christian Jobin. Locoregional effects of microbiota in a preclinical model of colon carcinogenesis. Cancer Research. 2017. 77(10):2620-2632 (IF 8.6)
Patricia Martin, Sophie Tronnet, Christophe Garcie, Eric Oswald. Interplay between siderophores and colibactin genotoxin in Escherichia coli. IUBMB Life. 2017. doi: 10.1002/iub.1612. (IF 2.6)
Besson-Fournier C, Gineste A, Latour C, Gourbeyre O, Meynard D, Martin P, Oswald E, Coppin H, Roth MP. Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B. Blood. 2017 Jan 26;129(4):533-536.
Sophie Tronnet, Christophe Garcie, Nadine Rehms, Ulrich Dobrindt, Eric Oswald, Patricia Martin. Iron homeostasis regulates the genotoxicity of Escherichia coli producing colibactin. Infect Immun. Infection and immunity. 2016. 84(12):3358-3368 (IF 3.7)
Christophe Garcie, Sophie Tronnet, Amélie Garénaux, A.J. McCarthy, A.O. Brachmann, Marie Pénary, Sébastien Houle, J-P. Nougayrède, Jorn Piel, P.W. Taylor, C.M. Dozois, Pierre Genevaux, Eris Oswald, Patricia Martin. The stress-responsive Hsp90 chaperone controls genotoxin and siderophore production by pathogenic Escherichia coli. Journal of Infectious Diseases. 2016. 214(6):916-24 (IF 6.0)
Patricia Martin*, Kazunori Murase*, Gaëlle Porcheron, Sebastien Houle, Emmanuelle Helloin, Marie Pénary, Jean-Philippe Nougayrède, Charles Dozois, Tetsuya Hayashi, Eric Oswald. HlyF produced by extraintestinal pathogenic Escherichia coli is a virulence factor that regulates outer membrane vesicle biogenesis. Journal of Infectious Diseases. 2016. 213(5):856-65. *co-premier auteur. (IF 6.0)
Aurélie Gineste, Patricia Martin, Eric Oswald, Hélène Coppin, Marie-Paule Roth, 2015 Evidence for IL-6/STAT3-independent induction of lipocalin-2 in the liver of mice infected with Escherichia coli, Hepathology doi: 10.1002/hep.27845. (IF 11.0)
Brevet
1°) Date de dépôt : 03/07/2013 ; Numéro de dépôt : EP13305943.6
Methods for the screening of substances that may be useful for the prevention and treatment of infections by enterobacteriaceae family
Inventeurs : Eric Oswald, Patricia Martin
2°) Date de dépôt : 07/04/2014 ; Numéro de dépôt : EP14305508.5
New method for producing outer membrane vesicles.
Inventeurs: Eric Oswald, Patricia Martin, Kazunori Murase
Pérez-Berezo T, Pujo J, Martin P, Le Faouder P, Galano JM, Guy A, Knauf C, Tabet JC, Tronnet S, Barreau F, Heuillet M, Dietrich G, Bertrand-Michel J, Durand T, Oswald E, Cenac N. Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917. Nat Commun. 2017 Nov 3;8(1):1314.
Delphine Payros D, Ulrich Dobrindt U, Patricia Martin, Thomas Secher, Ana Paula Bracarense, Michèle Boury, Joelle Laffitte, Philippe Pinton, Eric Oswald and Isabelle Oswald. The Food Contaminant Deoxynivalenol Exacerbates the Genotoxicity of Gut Microbiota. MBio. 2017. 8(2) pii: e00007-17 (IF 6.4)
Tronnet S, Garcie C, Brachmann AO, Piel J, Oswald E, Martin P. High iron supply inhibits the synthesis of the genotoxin colibactin by pathogenic Escherichia coli through a non-canonical Fur/RyhB-mediated pathway. Pathog Dis. 2017 Jul 31;75(5).
Sarah Tomkovich, Ye Yang, Kathryn Winglee, Josee Gauthier, Marcus Mühlbauer, Xiaolun Sun, Mansour Mohamadzadeh, Xiuli Liu, Patricia Martin, Gary P. Wang, Eric Oswald, Anthony A. Fodor, Christian Jobin. Locoregional effects of microbiota in a preclinical model of colon carcinogenesis. Cancer Research. 2017. 77(10):2620-2632 (IF 8.6)
Patricia Martin, Sophie Tronnet, Christophe Garcie, Eric Oswald. Interplay between siderophores and colibactin genotoxin in Escherichia coli. IUBMB Life. 2017. doi: 10.1002/iub.1612. (IF 2.6)
Besson-Fournier C, Gineste A, Latour C, Gourbeyre O, Meynard D, Martin P, Oswald E, Coppin H, Roth MP. Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B. Blood. 2017 Jan 26;129(4):533-536.
Sophie Tronnet, Christophe Garcie, Nadine Rehms, Ulrich Dobrindt, Eric Oswald, Patricia Martin. Iron homeostasis regulates the genotoxicity of Escherichia coli producing colibactin. Infect Immun. Infection and immunity. 2016. 84(12):3358-3368 (IF 3.7)
Christophe Garcie, Sophie Tronnet, Amélie Garénaux, A.J. McCarthy, A.O. Brachmann, Marie Pénary, Sébastien Houle, J-P. Nougayrède, Jorn Piel, P.W. Taylor, C.M. Dozois, Pierre Genevaux, Eris Oswald, Patricia Martin. The stress-responsive Hsp90 chaperone controls genotoxin and siderophore production by pathogenic Escherichia coli. Journal of Infectious Diseases. 2016. 214(6):916-24 (IF 6.0)
Patricia Martin*, Kazunori Murase*, Gaëlle Porcheron, Sebastien Houle, Emmanuelle Helloin, Marie Pénary, Jean-Philippe Nougayrède, Charles Dozois, Tetsuya Hayashi, Eric Oswald. HlyF produced by extraintestinal pathogenic Escherichia coli is a virulence factor that regulates outer membrane vesicle biogenesis. Journal of Infectious Diseases. 2016. 213(5):856-65. *co-premier auteur. (IF 6.0)
Aurélie Gineste, Patricia Martin, Eric Oswald, Hélène Coppin, Marie-Paule Roth, 2015 Evidence for IL-6/STAT3-independent induction of lipocalin-2 in the liver of mice infected with Escherichia coli, Hepathology doi: 10.1002/hep.27845. (IF 11.0)
Brevet
1°) Date de dépôt : 03/07/2013 ; Numéro de dépôt : EP13305943.6
Methods for the screening of substances that may be useful for the prevention and treatment of infections by enterobacteriaceae family
Inventeurs : Eric Oswald, Patricia Martin
2°) Date de dépôt : 07/04/2014 ; Numéro de dépôt : EP14305508.5
New method for producing outer membrane vesicles.
Inventeurs: Eric Oswald, Patricia Martin, Kazunori Murase
