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EQUIPE 2 : PATHOGÉNIE ET COMMENSALISME DES ENTEROBACTÉRIES
TEAM 2 : PATHOGENESIS AND COMMENSALISM OF ENTEROBACTERIA |
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Mini CV
- September 2014-December 2016 :
Post-doctorate (BBSRC contract)
Topic : Linking genotype and phenotypic diversity of the intestinal pathogen Salmonella Typhimurium
Supervisor : Robert Kingsley, Institute of Food research, Norwich (UK), Gut Health and Food safety departement - January 2013-August 2014 :
Post-doctorate (ANR contract)
Topic : Morphology and biofilm structure at water-hydrophobic organic compounds of the marine bacteria Marinobacter hydrocarbonoclasticus SP17
Supervisor : Murielle Naïtali, INRA Massy (91, France), MICALIS unit - October 2008-December 2012 :
PhD molecular microbiology (INRA-Auvergne Region Fellowship and one year Fondation pour la Recherche Médicale)
Topic : Identification of regulatory pathway controling Enterohaemorrhagic E. coli motility, biofilm formation and the locus of enterocyte effacement
Supervisor : Christine Martin, INRA Clermont-Ferrand/Theix (63, France), Microbiology unit
- Septembre 2014-Decembre 2016 :
Post-doctorat (contrat BBSRC)
Sujet : Relation entre le genotype et la diversité phénotypique du pathogène intestinal Salmonella Typhimurium
Superviseur : Robert Kingsley, Institute of Food research, Norwich (UK), département Gut Health and Food safety - Janvier 2013-Août 2014 :
Post-doctorat (contrat ANR)
Sujet : Morpholgie et structure des biofilms de la bactérie marine Marinobacter hydrocarbonoclasticus SP17 à l’interface Eau-composé organiques hydrophobes
Superviseur : Murielle Naïtali, INRA Massy (91, France), unité MICALIS - Octobre 2008-Decembre 2012 :
PhD molecular microbiology (Bourse INRA-Région Auvergne et un an Fondation pour la recherche médicale)
Sujet : Identification de voies de régulation contrôlant la mobilité, la formation de biofilms et le locus d’effacement des enterocytes chez les Escherichia coli entérohémorragiques
Superviseur : Christine Martin, INRA Clermont-Ferrand/Theix (63, France), unité de Microbiologie
Recherche/projet research/project
MOLECULAR BASES OF COMMENSALISM AND PATHOGENESIS OF ENTEROBACTERIA
Production scientifique scientific production
- Chagneau CV, Payros D, Goman A, Goursat C, David L, Okuno M, Bordignon PJ, Séguy C, Massip C, Branchu P, Ogura Y, Nougayrède JP, Marenda M, Oswald E. HlyF, an underestimated virulence factor of uropathogenic Escherichia coli. Clin Microbiol Infect. 2023. S1198-743X(23)00352-X
- Auvray F, Perrat A, Arimizu Y, Chagneau CV, Bossuet-Greif N, Massip C, Brugère H, Nougayrède JP, Hayashi T, Branchu P, Ogura Y, Oswald E. Insights into the acquisition of the pks island and production of colibactin in the Escherichia coli population. Microb Genom. 2021;7(5):000579. doi: 10.1099/mgen.0.000579. PMID: 33961542; PMCID: PMC8209727.
- Kirkwood M, Vohra P, Bawn M, Thilliez G, Pye H, Tanner J, Chintoan-Uta C, Branchu P, Petrovska L, Dallman T, Hall N, Stevens MP, Kingsley RA. Ecological niche adaptation of Salmonella Typhimurium U288 is associated with altered pathogenicity and reduced zoonotic potential. Commun Biol. 2021;4(1):498. doi: 10.1038/s42003-021-02013-4. PMID: 33893390; PMCID: PMC8065163.
- Tang-Fichaux M, Chagneau CV, Bossuet-Greif N, Nougayrède JP, Oswald É, Branchu P. The Polyphosphate Kinase of Escherichia coli Is Required for Full Production of the Genotoxin Colibactin. mSphere. 2020;5(6):e01195-20. doi: 10.1128/mSphere.01195-20. PMID: 33328353; PMCID: PMC7771237.
- Massip C, Branchu P, Bossuet-Greif N, Chagneau CV, Gaillard D, Martin P, Boury M, Sécher T, Dubois D, Nougayrède JP, Oswald E. Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917. PLoS Pathog. 2019;15(9):e1008029. doi: 10.1371/journal.ppat.1008029. PMID: 31545853; PMCID: PMC6776366.
- Branchu P, Charity OJ, Bawn M, Thilliez G, Dallman TJ, Petrovska L, Kingsley RA. SGI-4 in Monophasic Salmonella Typhimurium ST34 Is a Novel ICE That Enhances Resistance to Copper. Front Microbiol. 2019 10:1118.
- Mounier J, Hakil F, Branchu P, Naïtali M, Goulas P, Sivadon P, Grimaud R. AupA and AupB Are Outer and Inner Membrane Proteins Involved in Alkane Uptake in Marinobacter hydrocarbonoclasticus SP17. MBio. 2018 9(3)
- Branchu P, Bawn M, Kingsley RA. Genome variation and molecular epidemiology of Salmonella Typhimurium pathovariants. Infect Immun. 2018 pii: IAI.00079-18. doi: 10.1128/IAI.00079-18.
- Métris A, Sudhakar P, Fazekas D, Demeter A, Ari E, Olbei M, Branchu P, Kingsley RA, Baranyi J, Korcsmáros T. SalmoNet, an integrated network of ten Salmonella enterica strains reveals common and distinct pathways to host adaptation. NPJ Syst Biol Appl. 2017 doi: 10.1038/s41540-017-0034-z. eCollection 2017
- Branchu P, Canette A, Medina Fernandez S, Mounier J, Meylheuc T, Briandet R, Grimaud R, Naïtali M. Impact of temperature on Marinobacter hydrocarbonoclasticus SP17 morphology and biofilm structure during growth on alkanes. Microbiology. 2017 doi: 10.1099/mic.0.000466. [Epub ahead of print]
- Ennouri H, d'Abzac P, Hakil F, Branchu P, Naïtali M, Lomenech AM, Oueslati R, Desbrières J, Sivadon P, Grimaud R. The extracellular matrix of the oleolytic biofilms of Marinobacter hydrocarbonoclasticus comprises cytoplasmic proteins and T2SS effectors that promote growth on hydrocarbons and lipids. Environ Microbiol. 2017 19(1):159-173
- L. Petrovska, A. E. Mather, M. Aubuoun, P. Branchu, S. R. Harris, T. Connor, K. L. Hopkins, A. Underwood, A. A. Lettini, A. Page, M. Bagnall, J. Wain, J. Parkhill, G. Dougan, R. Davies, R. A. Kingsley. Microevolution during the emergence of a monophasic Salmonella Typhimurium epidemic in the United Kingdom. Emerg Infect Dis. 2016;22(4):617-24
- A. Canette, P. Branchu, R. Grimaud, and M. Naïtali. Imaging bacterial cells and biofilms adhering to hydrophobic organic compounds-water interfaces. McGenity, Terry J., Timmis, Kenneth N., Nogales Fernández, Balbina Hydrocarbon and Lipid Microbiology Protocols , 2016, Springer Protocols Handbooks, 978-3-662-49135-5.
- P. Branchu, S. Matrat, M. Vareille, A. Garrivier, A. Durand, S. Crépin, J. Harel, G. Jubelin, A. P. Gobert. NsrR, GadE and GadX interplay in repressing expression of the Escherichia coli O157:H7 LEE pathogenicity island in response ot nitric oxide. PLoS Pathogens, 2014;10(1) e1003874)
- P. Branchu, T. Hindré, X. Fang, R. Thomas, M. Gomeslky, L. Claret, J. Harel, A. P. Gobert, C. Martin. The c-di-GMP phosphodiesterase VmpA absent in Escherichia coli K-12 strains affects motility and biofilm formation in the enterohemorrhagic O157:H7 serotype. Vet Immunol Immunopathol., 2013;152(1-2):132-40
- C. Braem, B.Recolin, R. C. Rancourt, C. Angiolini, P.Barthès, P.Branchu, F. Court, G. Cathala, A. C. Ferguson-Smith, T. Forné. Genomic matrix attachment region and chromosome conformation capture quantitative real time PCR assays identify novel putative regulatory elements at the imprinted Dlk1/Gtl2 locus. J Biol Chem., 2008;283(27):18612-20
- Auvray F, Perrat A, Arimizu Y, Chagneau CV, Bossuet-Greif N, Massip C, Brugère H, Nougayrède JP, Hayashi T, Branchu P, Ogura Y, Oswald E. Insights into the acquisition of the pks island and production of colibactin in the Escherichia coli population. Microb Genom. 2021;7(5):000579. doi: 10.1099/mgen.0.000579. PMID: 33961542; PMCID: PMC8209727.
- Kirkwood M, Vohra P, Bawn M, Thilliez G, Pye H, Tanner J, Chintoan-Uta C, Branchu P, Petrovska L, Dallman T, Hall N, Stevens MP, Kingsley RA. Ecological niche adaptation of Salmonella Typhimurium U288 is associated with altered pathogenicity and reduced zoonotic potential. Commun Biol. 2021;4(1):498. doi: 10.1038/s42003-021-02013-4. PMID: 33893390; PMCID: PMC8065163.
- Tang-Fichaux M, Chagneau CV, Bossuet-Greif N, Nougayrède JP, Oswald É, Branchu P. The Polyphosphate Kinase of Escherichia coli Is Required for Full Production of the Genotoxin Colibactin. mSphere. 2020;5(6):e01195-20. doi: 10.1128/mSphere.01195-20. PMID: 33328353; PMCID: PMC7771237.
- Massip C, Branchu P, Bossuet-Greif N, Chagneau CV, Gaillard D, Martin P, Boury M, Sécher T, Dubois D, Nougayrède JP, Oswald E. Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917. PLoS Pathog. 2019;15(9):e1008029. doi: 10.1371/journal.ppat.1008029. PMID: 31545853; PMCID: PMC6776366.
- Branchu P, Charity OJ, Bawn M, Thilliez G, Dallman TJ, Petrovska L, Kingsley RA. SGI-4 in Monophasic Salmonella Typhimurium ST34 Is a Novel ICE That Enhances Resistance to Copper. Front Microbiol. 2019 10:1118.
- Mounier J, Hakil F, Branchu P, Naïtali M, Goulas P, Sivadon P, Grimaud R. AupA and AupB Are Outer and Inner Membrane Proteins Involved in Alkane Uptake in Marinobacter hydrocarbonoclasticus SP17. MBio. 2018 9(3)
- Branchu P, Bawn M, Kingsley RA. Genome variation and molecular epidemiology of Salmonella Typhimurium pathovariants. Infect Immun. 2018 pii: IAI.00079-18. doi: 10.1128/IAI.00079-18.
- Métris A, Sudhakar P, Fazekas D, Demeter A, Ari E, Olbei M, Branchu P, Kingsley RA, Baranyi J, Korcsmáros T. SalmoNet, an integrated network of ten Salmonella enterica strains reveals common and distinct pathways to host adaptation. NPJ Syst Biol Appl. 2017 doi: 10.1038/s41540-017-0034-z. eCollection 2017
- Branchu P, Canette A, Medina Fernandez S, Mounier J, Meylheuc T, Briandet R, Grimaud R, Naïtali M. Impact of temperature on Marinobacter hydrocarbonoclasticus SP17 morphology and biofilm structure during growth on alkanes. Microbiology. 2017 doi: 10.1099/mic.0.000466. [Epub ahead of print]
- Ennouri H, d'Abzac P, Hakil F, Branchu P, Naïtali M, Lomenech AM, Oueslati R, Desbrières J, Sivadon P, Grimaud R. The extracellular matrix of the oleolytic biofilms of Marinobacter hydrocarbonoclasticus comprises cytoplasmic proteins and T2SS effectors that promote growth on hydrocarbons and lipids. Environ Microbiol. 2017 19(1):159-173
- L. Petrovska, A. E. Mather, M. Aubuoun, P. Branchu, S. R. Harris, T. Connor, K. L. Hopkins, A. Underwood, A. A. Lettini, A. Page, M. Bagnall, J. Wain, J. Parkhill, G. Dougan, R. Davies, R. A. Kingsley. Microevolution during the emergence of a monophasic Salmonella Typhimurium epidemic in the United Kingdom. Emerg Infect Dis. 2016;22(4):617-24
- A. Canette, P. Branchu, R. Grimaud, and M. Naïtali. Imaging bacterial cells and biofilms adhering to hydrophobic organic compounds-water interfaces. McGenity, Terry J., Timmis, Kenneth N., Nogales Fernández, Balbina Hydrocarbon and Lipid Microbiology Protocols , 2016, Springer Protocols Handbooks, 978-3-662-49135-5.
- P. Branchu, S. Matrat, M. Vareille, A. Garrivier, A. Durand, S. Crépin, J. Harel, G. Jubelin, A. P. Gobert. NsrR, GadE and GadX interplay in repressing expression of the Escherichia coli O157:H7 LEE pathogenicity island in response ot nitric oxide. PLoS Pathogens, 2014;10(1) e1003874)
- P. Branchu, T. Hindré, X. Fang, R. Thomas, M. Gomeslky, L. Claret, J. Harel, A. P. Gobert, C. Martin. The c-di-GMP phosphodiesterase VmpA absent in Escherichia coli K-12 strains affects motility and biofilm formation in the enterohemorrhagic O157:H7 serotype. Vet Immunol Immunopathol., 2013;152(1-2):132-40
- C. Braem, B.Recolin, R. C. Rancourt, C. Angiolini, P.Barthès, P.Branchu, F. Court, G. Cathala, A. C. Ferguson-Smith, T. Forné. Genomic matrix attachment region and chromosome conformation capture quantitative real time PCR assays identify novel putative regulatory elements at the imprinted Dlk1/Gtl2 locus. J Biol Chem., 2008;283(27):18612-20
