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EQUIPE 1 : PHYSIOPATHOLOGIE DE L’EPITHELIUM INTESTINAL
TEAM 1 : PATHOPHYSIOLOGY OF THE INTESTINAL EPITHELIUM PLATEFORME ORGANOÏDES
CORE FACILITY ORGANOÏDS |
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Mini CV
Nathalie Vergnolle, directrice de recherche à l’INSERM, est depuis le 1er janvier 2016 à la tête de l’ Institut de Recherche en Santé Digestive. Elle est également responsable de l’équipe «Pathophysiologie de l’épithélium intestinal ».
Avant de mener ses recherches à Toulouse, le Dr Vergnolle a passé 10 ans à l'Université de Calgary (Canada) au sein du département de Pharmacologie. Ses travaux ont permis de mettre en évidence le rôle de plusieurs médiateurs impliqués dans l'inflammation et la douleur. En collaboration avec des chercheurs de l’INRA et de l’Institut Pasteur, son équipe a produit des bactéries capables de protéger l’organisme des inflammations intestinales à partir d'une protéine humaine, l’Élafine. Ses recherches lui ont valu une reconnaissance internationale et sont soutenues au niveau européen, national et régional. Elles ont mené à des collaborations académiques et privées très actives.
Nathalie Vergnolle, research director at INSERM, is since 1 January 2016 as head of the Research Institute for Digestive Health. She is also responsible for the team "Pathophysiology of the intestinal epithelium."
Before conducting her research in Toulouse, Dr. Vergnolle spent 10 years at the University of Calgary (Canada) in the Department of Pharmacology. Her work has highlighted the role of several mediators involved in inflammation and pain. In collaboration with researchers from INRA and the Pasteur Institute, her team produced bacteria expressing a human protein, elafin that can protect the body from intestinal inflammation. Her researches have earned him international recognition and are supported at European, national and regional level. They have led to very active academic and private collaborations .
FORMATION
• 1997 : Doctorat en Sciences biologiques, Université Toulouse III, France, Laboratoire de pharmacologie de l’INRA (direction L. Bueno)
POSITIONS
• 1997-2000 : Stage Post-doctoral, Université de Calgary, Canada, Laboratoire de John Wallace
• 2000 : Nommée Assistant Professor, Université de Calgary, Canada
• 2004 : Nommée Associate Professor, Université de Calgary, Canada
• 2007 : Nommée Directrice de Recherche 2ème classe INSERM, Toulouse, direction d’une équipe INSERM-AVENIR soutenue par la fondation Bettencourt-Schueller.
• 2011 : Nommée Directrice de Recherche 1ère classe INSERM, Toulouse, leader d’une equipe INSERM.
• 2016 : Nommée Directrice de l’Institut de Recherche en Santé Digestive.
DISTINCTIONS
• Prix Coup d’Elan de la Recherche Scientifique Fondation Bettencourt Schueller 2016.
• Chevalier de la légion d'honneur, 2013
• Femme en Science de l’inflammation, International Association of Inflammation Societies, 2013
• Subvention du Conseil Européen de la Recherche (ERC Consolidator Grant), 2012
• Master Award en Gastroenterologie (Association de Gastroenterologie Americaine) 2006
Avant de mener ses recherches à Toulouse, le Dr Vergnolle a passé 10 ans à l'Université de Calgary (Canada) au sein du département de Pharmacologie. Ses travaux ont permis de mettre en évidence le rôle de plusieurs médiateurs impliqués dans l'inflammation et la douleur. En collaboration avec des chercheurs de l’INRA et de l’Institut Pasteur, son équipe a produit des bactéries capables de protéger l’organisme des inflammations intestinales à partir d'une protéine humaine, l’Élafine. Ses recherches lui ont valu une reconnaissance internationale et sont soutenues au niveau européen, national et régional. Elles ont mené à des collaborations académiques et privées très actives.
Nathalie Vergnolle, research director at INSERM, is since 1 January 2016 as head of the Research Institute for Digestive Health. She is also responsible for the team "Pathophysiology of the intestinal epithelium."
Before conducting her research in Toulouse, Dr. Vergnolle spent 10 years at the University of Calgary (Canada) in the Department of Pharmacology. Her work has highlighted the role of several mediators involved in inflammation and pain. In collaboration with researchers from INRA and the Pasteur Institute, her team produced bacteria expressing a human protein, elafin that can protect the body from intestinal inflammation. Her researches have earned him international recognition and are supported at European, national and regional level. They have led to very active academic and private collaborations .
FORMATION
• 1997 : Doctorat en Sciences biologiques, Université Toulouse III, France, Laboratoire de pharmacologie de l’INRA (direction L. Bueno)
POSITIONS
• 1997-2000 : Stage Post-doctoral, Université de Calgary, Canada, Laboratoire de John Wallace
• 2000 : Nommée Assistant Professor, Université de Calgary, Canada
• 2004 : Nommée Associate Professor, Université de Calgary, Canada
• 2007 : Nommée Directrice de Recherche 2ème classe INSERM, Toulouse, direction d’une équipe INSERM-AVENIR soutenue par la fondation Bettencourt-Schueller.
• 2011 : Nommée Directrice de Recherche 1ère classe INSERM, Toulouse, leader d’une equipe INSERM.
• 2016 : Nommée Directrice de l’Institut de Recherche en Santé Digestive.
DISTINCTIONS
• Prix Coup d’Elan de la Recherche Scientifique Fondation Bettencourt Schueller 2016.
• Chevalier de la légion d'honneur, 2013
• Femme en Science de l’inflammation, International Association of Inflammation Societies, 2013
• Subvention du Conseil Européen de la Recherche (ERC Consolidator Grant), 2012
• Master Award en Gastroenterologie (Association de Gastroenterologie Americaine) 2006
Recherche/projet research/project
Production scientifique scientific production
PAR2-dependent activation of GSK3β regulates the survival of colon stem/progenitor cells.
Nasri I, Bonnet D, Zwarycz B, D'Aldebert E, Khou S, Mezghani-Jarraya R, Quaranta M, Rolland C, Bonnart C, Mas E, Ferrand A, Cenac N, Magness S, Van Landeghem L, Vergnolle N, Racaud-Sultan C.
Am J Physiol Gastrointest Liver Physiol. 2016 Jun 16:ajpgi.00328.2015. doi: 10.1152/ajpgi.00328.2015.
[Epub ahead of print]
Endogenous analgesia mediated by CD4(+) T lymphocytes is dependent on enkephalins in mice.
Basso L, Boué J, Mahiddine K, Blanpied C, Robiou-du-Pont S, Vergnolle N, Deraison C, Dietrich G.
J Neuroinflammation. 2016 Jun 1;13(1):132. doi: 10.1186/s12974-016-0591-x.
PMID: 27245576 Free PMC Article
Protease inhibition as new therapeutic strategy for GI diseases.
Vergnolle N.
Gut. 2016 Jul;65(7):1215-24. doi: 10.1136/gutjnl-2015-309147. Epub 2016 Apr 12. Review.
PMID: 27196587 Free PMC Article
The Intestinal Microenvironment and Functional Gastrointestinal Disorders.
Barbara G, Feinle-Bisset C, Ghoshal UC, Quigley EM, Santos J, Vanner S, Vergnolle N, Zoetendal EG.
Gastroenterology. 2016 Feb 18. pii: S0016-5085(16)00219-5. doi: 10.1053/j.gastro.2016.02.028. [Epub ahead of print]
PMID: 27144620
The arachidonic acid metabolite 11β-ProstaglandinF2α controls intestinal epithelial healing: deficiency in patients with Crohn's disease.
Coquenlorge S, Van Landeghem L, Jaulin J, Cenac N, Vergnolle N, Duchalais E, Neunlist M, Rolli-Derkinderen M.
Sci Rep. 2016 May 3;6:25203. doi: 10.1038/srep25203.
PMID: 27140063 Free PMC Article
Formyl Peptide Receptor 2 Plays a Deleterious Role During Influenza A Virus Infections.
Tcherniuk S, Cenac N, Comte M, Frouard J, Errazuriz-Cerda E, Galabov A, Morange PE, Vergnolle N, Si-Tahar M, Alessi MC, Riteau B.
J Infect Dis. 2016 Jul 15;214(2):237-47. doi: 10.1093/infdis/jiw127. Epub 2016 Mar 30.
PMID: 27034344
Sacral nerve stimulation enhances early intestinal mucosal repair following mucosal injury in a pig model.
Brégeon J, Coron E, Da Silva AC, Jaulin J, Aubert P, Chevalier J, Vergnolle N, Meurette G, Neunlist M.
J Physiol. 2016 Mar 4. doi: 10.1113/JP271783. [Epub ahead of print]
PMID: 26939757
Bladder telemetry: A new approach to evaluate micturition behavior under physiological and inflammatory conditions.
Monjotin N, Farrié M, Vergnolle N, Le Grand B, Gillespie J, Junquero D.
Neurourol Urodyn. 2016 Feb 16. doi: 10.1002/nau.22970. [Epub ahead of print]
PMID: 26879122
Reply.
Vergnolle N.
Gastroenterology. 2016 Mar;150(3):777-8. doi: 10.1053/j.gastro.2016.01.026. Epub 2016 Jan 29. No abstract available.
PMID: 26827802
Presence of commensal house dust mite allergen in human gastrointestinal tract: a potential contributor to intestinal barrier dysfunction.
Tulic MK, Vivinus-Nébot M, Rekima A, Rabelo Medeiros S, Bonnart C, Shi H, Walker A, Dainese R, Boyer J, Vergnolle N, Piche T, Verhasselt V.
Gut. 2016 May;65(5):757-66. doi: 10.1136/gutjnl-2015-310523. Epub 2015 Dec 8.
PMID: 26646935
Apelin targets gut contraction to control glucose metabolism via the brain.
Fournel A, Drougard A, Duparc T, Marlin A, Brierley SM, Castro J, Le-Gonidec S, Masri B, Colom A, Lucas A, Rousset P, Cenac N, Vergnolle N, Valet P, Cani PD, Knauf C.
Gut. 2015 Nov 12. pii: gutjnl-2015-310230. doi: 10.1136/gutjnl-2015-310230. [Epub ahead of print]
PMID: 26565000 Free Article
Defects in 15-HETE Production and Control of Epithelial Permeability by Human Enteric Glial Cells From Patients With Crohn's Disease.
Pochard C, Coquenlorge S, Jaulin J, Cenac N, Vergnolle N, Meurette G, Freyssinet M, Neunlist M, Rolli-Derkinderen M.
Gastroenterology. 2016 Jan;150(1):168-80. doi: 10.1053/j.gastro.2015.09.038. Epub 2015 Nov 11.
PMID: 26433161
TRPV1 sensitization mediates postinflammatory visceral pain following acute colitis.
Lapointe TK, Basso L, Iftinca MC, Flynn R, Chapman K, Dietrich G, Vergnolle N, Altier C.
Am J Physiol Gastrointest Liver Physiol. 2015 Jul 15;309(2):G87-99. doi: 10.1152/ajpgi.00421.2014. Epub 2015 May 28.
PMID: 26021808 Free Article
Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome.
Cenac N, Bautzova T, Le Faouder P, Veldhuis NA, Poole DP, Rolland C, Bertrand J, Liedtke W, Dubourdeau M, Bertrand-Michel J, Zecchi L, Stanghellini V, Bunnett NW, Barbara G, Vergnolle N.
Gastroenterology. 2015 Aug;149(2):433-44.e7. doi: 10.1053/j.gastro.2015.04.011. Epub 2015 Apr 22.
PMID: 25911511
Serine protease inhibitors protect better than IL-10 and TGF-β anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci.
Bermúdez-Humarán LG, Motta JP, Aubry C, Kharrat P, Rous-Martin L, Sallenave JM, Deraison C, Vergnolle N, Langella P.
Microb Cell Fact. 2015 Feb 26;14:26. doi: 10.1186/s12934-015-0198-4.
PMID: 25889561 Free PMC Article
Novel role of the serine protease inhibitor elafin in gluten-related disorders.
Galipeau HJ, Wiepjes M, Motta JP, Schulz JD, Jury J, Natividad JM, Pinto-Sanchez I, Sinclair D, Rousset P, Martin-Rosique R, Bermudez-Humaran L, Leroux JC, Murray JA, Smecuol E, Bai JC, Vergnolle N, Langella P, Verdu EF.
Am J Gastroenterol. 2014 May;109(5):748-56. doi: 10.1038/ajg.2014.48. Epub 2014 Apr 8.
PMID: 24710505 Free PMC Article
Activated protein C based therapeutic strategies in chronic diseases.
Bock F, Shahzad K, Vergnolle N, Isermann B.
Thromb Haemost. 2014 Apr 1;111(4):610-7. doi: 10.1160/TH13-11-0967. Epub 2014 Mar 20. Review.
PMID: 24652581
TRPV4: new therapeutic target for inflammatory bowel diseases.
Vergnolle N.
Biochem Pharmacol. 2014 May 15;89(2):157-61. doi: 10.1016/j.bcp.2014.01.005. Epub 2014 Jan 16. Review.
PMID: 24440740
Polyunsaturated fatty acid metabolism signature in ischemia differs from reperfusion in mouse intestine.
Gobbetti T, Le Faouder P, Bertrand J, Dubourdeau M, Barocelli E, Cenac N, Vergnolle N.
PLoS One. 2013 Sep 20;8(9):e75581. doi: 10.1371/journal.pone.0075581. eCollection 2013.
PMID: 24073272 Free PMC Article
Endogenous regulation of visceral pain via production of opioids by colitogenic CD4(+) T cells in mice.
Boué J, Basso L, Cenac N, Blanpied C, Rolli-Derkinderen M, Neunlist M, Vergnolle N, Dietrich G.
Gastroenterology. 2014 Jan;146(1):166-75. doi: 10.1053/j.gastro.2013.09.020. Epub 2013 Sep 18.
PMID: 24055279
Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model.
Aerts L, Hamelin MÈ, Rhéaume C, Lavigne S, Couture C, Kim W, Susan-Resiga D, Prat A, Seidah NG, Vergnolle N, Riteau B, Boivin G.
PLoS One. 2013 Aug 28;8(8):e72529. doi: 10.1371/journal.pone.0072529. eCollection 2013.
PMID: 24015257 Free PMC Article
Engineering lactococci and lactobacilli for human health.
Bermúdez-Humarán LG, Aubry C, Motta JP, Deraison C, Steidler L, Vergnolle N, Chatel JM, Langella P.
Curr Opin Microbiol. 2013 Jun;16(3):278-83. doi: 10.1016/j.mib.2013.06.002. Epub 2013 Jul 11. Review.
PMID: 23850097
LC-MS/MS method for rapid and concomitant quantification of pro-inflammatory and pro-resolving polyunsaturated fatty acid metabolites.
Le Faouder P, Baillif V, Spreadbury I, Motta JP, Rousset P, Chêne G, Guigné C, Tercé F, Vanner S, Vergnolle N, Bertrand-Michel J, Dubourdeau M, Cenac N.
J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Aug 1;932:123-33. doi: 10.1016/j.jchromb.2013.06.014. Epub 2013 Jun 15.
PMID: 23831705
A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation.
Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S, Perretti M.
Blood. 2013 Jul 25;122(4):608-17. doi: 10.1182/blood-2013-04-496661. Epub 2013 Jun 3.
PMID: 23733341 Free PMC Article
Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update.
LeBlanc JG, Aubry C, Cortes-Perez NG, de Moreno de LeBlanc A, Vergnolle N, Langella P, Azevedo V, Chatel JM, Miyoshi A, Bermúdez-Humarán LG.
FEMS Microbiol Lett. 2013 Jul;344(1):1-9. doi: 10.1111/1574-6968.12159. Epub 2013 May 16. Review.
PMID: 23600579 Free Article
TRPM8 activation attenuates inflammatory responses in mouse models of colitis.
Ramachandran R, Hyun E, Zhao L, Lapointe TK, Chapman K, Hirota CL, Ghosh S, McKemy DD, Vergnolle N, Beck PL, Altier C, Hollenberg MD.
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7476-81. doi: 10.1073/pnas.1217431110. Epub 2013 Apr 17.
PMID: 23596210 Free PMC Article
Relevance of the cyclophosphamide-induced cystitis model for pharmacological studies targeting inflammation and pain of the bladder.
Augé C, Chene G, Dubourdeau M, Desoubzdanne D, Corman B, Palea S, Lluel P, Vergnolle N, Coelho AM.
Eur J Pharmacol. 2013 May 5;707(1-3):32-40. doi: 10.1016/j.ejphar.2013.03.008. Epub 2013 Mar 26.
PMID: 23541724
New neostigmine-based behavioral mouse model of abdominal pain.
Fichna J, Lapointe T, Chapman K, Janecka A, Vergnolle N, Altier C, Storr MA.
Pharmacol Rep. 2012;64(5):1146-54.
PMID: 23238471 Free Article
Food-grade bacteria expressing elafin protect against inflammation and restore colon homeostasis.
Motta JP, Bermúdez-Humarán LG, Deraison C, Martin L, Rolland C, Rousset P, Boue J, Dietrich G, Chapman K, Kharrat P, Vinel JP, Alric L, Mas E, Sallenave JM, Langella P, Vergnolle N.
Sci Transl Med. 2012 Oct 31;4(158):158ra144. doi: 10.1126/scitranslmed.3004212.
PMID: 23115353 Free Article
Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling.
Despeaux M, Chicanne G, Rouer E, De Toni-Costes F, Bertrand J, Mansat-De Mas V, Vergnolle N, Eaves C, Payrastre B, Girault JA, Racaud-Sultan C.
Stem Cells. 2012 Aug;30(8):1597-610. doi: 10.1002/stem.1157.
PMID: 22714993 Free Article
A spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease.
Chabod M, Pedros C, Lamouroux L, Colacios C, Bernard I, Lagrange D, Balz-Hara D, Mosnier JF, Laboisse C, Vergnolle N, Andreoletti O, Roth MP, Liblau R, Fournié GJ, Saoudi A, Dejean AS.
PLoS Genet. 2012 Jan;8(1):e1002461. doi: 10.1371/journal.pgen.1002461. Epub 2012 Jan 19.
PMID: 22275874 Free PMC Article
Immune conditions associated with CD4+ T effector-induced opioid release and analgesia.
Boué J, Blanpied C, Djata-Cabral M, Pelletier L, Vergnolle N, Dietrich G.
Pain. 2012 Feb;153(2):485-93. doi: 10.1016/j.pain.2011.11.013. Epub 2011 Dec 19.
PMID: 22188867
Role of transient receptor potential vanilloid 4 in rat joint inflammation.
Denadai-Souza A, Martin L, de Paula MA, de Avellar MC, Muscará MN, Vergnolle N, Cenac N.
Arthritis Rheum. 2012 Jun;64(6):1848-58. doi: 10.1002/art.34345. Epub 2011 Dec 19.
PMID: 22184014 Free Article
Serine protease inhibition reduces post-ischemic granulocyte recruitment in mouse intestine.
Gobbetti T, Cenac N, Motta JP, Rolland C, Martin L, Andrade-Gordon P, Steinhoff M, Barocelli E, Vergnolle N. Am J Pathol. 2012 Jan;180(1):141-52. doi: 10.1016/j.ajpath.2011.09.031. Epub 2011 Nov 7.
PMID: 22067907
Mechanisms behind the anti-inflammatory actions of insulin.
Hyun E, Ramachandran R, Hollenberg MD, Vergnolle N.
Crit Rev Immunol. 2011;31(4):307-40. Review.
PMID: 21899513
Brain-gut interactions increase peripheral nociceptive signaling in mice with postinfectious irritable bowel syndrome.
Ibeakanma C, Ochoa-Cortes F, Miranda-Morales M, McDonald T, Spreadbury I, Cenac N, Cattaruzza F, Hurlbut D, Vanner S, Bunnett N, Vergnolle N, Vanner S.
Gastroenterology. 2011 Dec;141(6):2098-2108.e5. doi: 10.1053/j.gastro.2011.08.006. Epub 2011 Aug 19.
PMID: 21856270
Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferon-γ on human neutrophils and monocytes.
Shpacovitch VM, Feld M, Holzinger D, Kido M, Hollenberg MD, Levi-Schaffer F, Vergnolle N, Ludwig S, Roth J, Luger T, Steinhoff M.
Immunology. 2011 Jul;133(3):329-39. doi: 10.1111/j.1365-2567.2011.03443.x. Epub 2011 Apr 19.
PMID: 21501162 Free PMC Article
Endogenous opioid-mediated analgesia is dependent on adaptive T cell response in mice.
Boué J, Blanpied C, Brousset P, Vergnolle N, Dietrich G.
J Immunol. 2011 May 1;186(9):5078-84. doi: 10.4049/jimmunol.1003335. Epub 2011 Mar 21.
PMID: 21422247 Free Article
Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.
Motta JP, Magne L, Descamps D, Rolland C, Squarzoni-Dale C, Rousset P, Martin L, Cenac N, Balloy V, Huerre M, Fröhlich LF, Jenne D, Wartelle J, Belaaouaj A, Mas E, Vinel JP, Alric L, Chignard M, Vergnolle N, Sallenave JM.
Gastroenterology. 2011 Apr;140(4):1272-82. doi: 10.1053/j.gastro.2010.12.050. Epub 2011 Jan 1.
PMID: 21199654
Transient receptor potential vanilloid 4 activated inflammatory signals by intestinal epithelial cells and colitis in mice.
D'Aldebert E, Cenac N, Rousset P, Martin L, Rolland C, Chapman K, Selves J, Alric L, Vinel JP, Vergnolle N.
Gastroenterology. 2011 Jan;140(1):275-85. doi: 10.1053/j.gastro.2010.09.045. Epub 2010 Oct 1.
PMID: 20888819
Contribution of bone marrow-derived cells to the pro-inflammatory effects of protease-activated receptor-2 in colitis.
Hyun E, Andrade-Gordon P, Steinhoff M, Beck PL, Vergnolle N.
Inflamm Res. 2010 Sep;59(9):699-709. doi: 10.1007/s00011-010-0181-9. Epub 2010 Mar 26.
PMID: 20339899 Free PMC Article
Potentiation of TRPV4 signalling by histamine and serotonin: an important mechanism for visceral hypersensitivity.
Cenac N, Altier C, Motta JP, d'Aldebert E, Galeano S, Zamponi GW, Vergnolle N.
Gut. 2010 Apr;59(4):481-8. doi: 10.1136/gut.2009.192567.
PMID: 20332520
Insulin modulates protease-activated receptor 2 signaling: implications for the innate immune response.
Hyun E, Ramachandran R, Cenac N, Houle S, Rousset P, Saxena A, Liblau RS, Hollenberg MD, Vergnolle N.
J Immunol. 2010 Mar 1;184(5):2702-9. doi: 10.4049/jimmunol.0902171. Epub 2010 Jan 29.
PMID: 20118282 Free Article
Thrombin receptor: An endogenous inhibitor of inflammatory pain, activating opioid pathways.
Martin L, Augé C, Boué J, Buresi MC, Chapman K, Asfaha S, Andrade-Gordon P, Steinhoff M, Cenac N, Dietrich G, Vergnolle N.
Pain. 2009 Nov;146(1-2):121-9. doi: 10.1016/j.pain.2009.07.016. Epub 2009 Aug 11.
PMID: 19674841
Visceral afferents: what role in post-inflammatory pain?
Vergnolle N.
Auton Neurosci. 2010 Feb 16;153(1-2):79-83. doi: 10.1016/j.autneu.2009.07.015. Epub 2009 Aug 9. Review.
PMID: 19666242
Analgesic properties of S100A9 C-terminal domain: a mechanism dependent on calcium channel inhibition.
Dale CS, Altier C, Cenac N, Giorgi R, Juliano MA, Juliano L, Zamponi GW, Vergnolle N.
Fundam Clin Pharmacol. 2009 Aug;23(4):427-38. doi: 10.1111/j.1472-8206.2009.00686.x. Epub 2009 Jun 8.
PMID: 19515068
Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway.
Khoufache K, LeBouder F, Morello E, Laurent F, Riffault S, Andrade-Gordon P, Boullier S, Rousset P, Vergnolle N, Riteau B.
J Immunol. 2009 Jun 15;182(12):7795-802. doi: 10.4049/jimmunol.0803743.
PMID: 19494303 Free Article
Protease-activated receptors as drug targets in inflammation and pain.
Vergnolle N.
Pharmacol Ther. 2009 Sep;123(3):292-309. doi: 10.1016/j.pharmthera.2009.05.004. Epub 2009 May 28. Review.
PMID: 19481569
Triggering of proteinase-activated receptor 4 leads to joint pain and inflammation in mice.
McDougall JJ, Zhang C, Cellars L, Joubert E, Dixon CM, Vergnolle N.
Arthritis Rheum. 2009 Mar;60(3):728-37. doi: 10.1002/art.24300.
PMID: 19248120 Free Article
Development, plasticity and modulation of visceral afferents.
Christianson JA, Bielefeldt K, Altier C, Cenac N, Davis BM, Gebhart GF, High KW, Kollarik M, Randich A, Undem B, Vergnolle N.
Brain Res Rev. 2009 Apr;60(1):171-86. doi: 10.1016/j.brainresrev.2008.12.004. Epub 2008 Dec 25. Review.
PMID: 19150371 Free PMC Article
Neutrophil-mediated activation of epithelial protease-activated receptors-1 and -2 regulates barrier function and transepithelial migration.
Chin AC, Lee WY, Nusrat A, Vergnolle N, Parkos CA.
J Immunol. 2008 Oct 15;181(8):5702-10.
PMID: 18832729 Free PMC Article
Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms.
Cenac N, Altier C, Chapman K, Liedtke W, Zamponi G, Vergnolle N.
Gastroenterology. 2008 Sep;135(3):937-46, 946.e1-2. doi: 10.1053/j.gastro.2008.05.024. Epub 2008 May 10.
PMID: 18565335
Derivatized 2-furoyl-LIGRLO-amide, a versatile and selective probe for proteinase-activated receptor 2: binding and visualization.
Hollenberg MD, Renaux B, Hyun E, Houle S, Vergnolle N, Saifeddine M, Ramachandran R.
J Pharmacol Exp Ther. 2008 Aug;326(2):453-62. doi: 10.1124/jpet.108.136432. Epub 2008 May 13.
PMID: 18477767 Free Article
Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection.
Feld M, Shpacovitch VM, Ehrhardt C, Kerkhoff C, Hollenberg MD, Vergnolle N, Ludwig S, Steinhoff M.
J Immunol. 2008 May 15;180(10):6903-10.
PMID: 18453611 Free Article
Protease signaling to G protein-coupled receptors: implications for inflammation and pain.
Dale C, Vergnolle N.
J Recept Signal Transduct Res. 2008;28(1-2):29-37. doi: 10.1080/10799890801941913 . Review.
PMID: 18437628
Proteinase-activated receptors (PARs) in infection and inflammation in the gut.
Vergnolle N.
Int J Biochem Cell Biol. 2008;40(6-7):1219-27. doi: 10.1016/j.biocel.2008.01.016. Epub 2008 Jan 20. Review.
PMID: 18313348
Mechanisms underlying the nociceptive and inflammatory responses induced by trypsin in the mouse paw.
Paszcuk AF, Quintão NL, Fernandes ES, Juliano L, Chapman K, Andrade-Gordon P, Campos MM, Vergnolle N, Calixto JB.
Eur J Pharmacol. 2008 Feb 26;581(1-2):204-15. Epub 2007 Nov 23.
PMID: 18083162
Intrathecal administration of proteinase-activated receptor-2 agonists produces hyperalgesia by exciting the cell bodies of primary sensory neurons.
Alier KA, Endicott JA, Stemkowski PL, Cenac N, Cellars L, Chapman K, Andrade-Gordon P, Vergnolle N, Smith PA.
J Pharmacol Exp Ther. 2008 Jan;324(1):224-33. Epub 2007 Oct 5.
PMID: 17921188 Free Article
Proteinase-activated receptor-2 exerts protective and pathogenic cell type-specific effects in Alzheimer's disease.
Afkhami-Goli A, Noorbakhsh F, Keller AJ, Vergnolle N, Westaway D, Jhamandas JH, Andrade-Gordon P, Hollenberg MD, Arab H, Dyck RH, Power C.
J Immunol. 2007 Oct 15;179(8):5493-503.
PMID: 17911636 Free Article
Agonists of proteinase-activated receptor-2 affect transendothelial migration and apoptosis of human neutrophils.
Shpacovitch VM, Seeliger S, Huber-Lang M, Balkow S, Feld M, Hollenberg MD, Sarma VJ, Ward PA, Strey A, Gerke V, Sommerhoff CP, Vergnolle N, Steinhoff M.
Exp Dermatol. 2007 Oct;16(10):799-806.
PMID: 17845211
Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia.
Knecht W, Cottrell GS, Amadesi S, Mohlin J, Skåregärde A, Gedda K, Peterson A, Chapman K, Hollenberg MD, Vergnolle N, Bunnett NW.
J Biol Chem. 2007 Sep 7;282(36):26089-100. Epub 2007 Jul 10.
PMID: 17623652 Free Article
Differential role of N-type calcium channel splice isoforms in pain.
Altier C, Dale CS, Kisilevsky AE, Chapman K, Castiglioni AJ, Matthews EA, Evans RM, Dickenson AH, Lipscombe D, Vergnolle N, Zamponi GW.
J Neurosci. 2007 Jun 13;27(24):6363-73.
PMID: 17567797 Free Article
Citrobacter rodentium infection causes iNOS-independent intestinal epithelial dysfunction in mice.
Skinn AC, Vergnolle N, Zamuner SR, Wallace JL, Cellars L, MacNaughton WK, Sherman PM.
Can J Physiol Pharmacol. 2006 Dec;84(12):1301-12.
PMID: 17487239
Proteinase-activated receptor-2 (PAR2): a tumor suppressor in skin carcinogenesis.
Rattenholl A, Seeliger S, Buddenkotte J, Schön M, Schön MP, Ständer S, Vergnolle N, Steinhoff M.
J Invest Dermatol. 2007 Sep;127(9):2245-52. Epub 2007 May 3.
PMID: 17476297 Free Article
Role for protease activity in visceral pain in irritable bowel syndrome.
Cenac N, Andrews CN, Holzhausen M, Chapman K, Cottrell G, Andrade-Gordon P, Steinhoff M, Barbara G, Beck P, Bunnett NW, Sharkey KA, Ferraz JG, Shaffer E, Vergnolle N.
J Clin Invest. 2007 Mar;117(3):636-47. Epub 2007 Feb 15.
PMID: 17304351 Free PMC Article
Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice.
Grant AD, Cottrell GS, Amadesi S, Trevisani M, Nicoletti P, Materazzi S, Altier C, Cenac N, Zamponi GW, Bautista-Cruz F, Lopez CB, Joseph EK, Levine JD, Liedtke W, Vanner S, Vergnolle N, Geppetti P, Bunnett NW.
J Physiol. 2007 Feb 1;578(Pt 3):715-33. Epub 2006 Nov 23.
PMID: 17124270 Free PMC Article
A role for proteinase-activated receptor-1 in inflammatory bowel diseases.
Vergnolle N, Cellars L, Mencarelli A, Rizzo G, Swaminathan S, Beck P, Steinhoff M, Andrade-Gordon P, Bunnett NW, Hollenberg MD, Wallace JL, Cirino G, Fiorucci S.
J Clin Invest. 2006 Jul;116(7):2056. No abstract available.
PMID: 16881139 Free PMC Article
Protective effect of proteinase-activated receptor 2 activation on motility impairment and tissue damage induced by intestinal ischemia/reperfusion in rodents.
Cattaruzza F, Cenac N, Barocelli E, Impicciatore M, Hyun E, Vergnolle N, Sternini C.
Am J Pathol. 2006 Jul;169(1):177-88.
PMID: 16816371 Free PMC Article
Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs).
Oikonomopoulou K, Hansen KK, Saifeddine M, Vergnolle N, Tea I, Blaber M, Blaber SI, Scarisbrick I, Diamandis EP, Hollenberg MD.
Biol Chem. 2006 Jun;387(6):817-24.
PMID: 16800746
Proteinase-mediated cell signalling: targeting proteinase-activated receptors (PARs) by kallikreins and more.
Oikonomopoulou K, Hansen KK, Saifeddine M, Vergnolle N, Tea I, Diamandis EP, Hollenberg MD.
Biol Chem. 2006 Jun;387(6):677-85. Review.
PMID: 16800728
Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice.
Amadesi S, Cottrell GS, Divino L, Chapman K, Grady EF, Bautista F, Karanjia R, Barajas-Lopez C, Vanner S, Vergnolle N, Bunnett NW.
J Physiol. 2006 Sep 1;575(Pt 2):555-71. Epub 2006 Jun 22.
PMID: 16793902 Free PMC Article
Proteinase-activated receptors (PARs): crossroads between innate immunity and coagulation.
Cirino G, Vergnolle N.
Curr Opin Pharmacol. 2006 Aug;6(4):428-34. Epub 2006 Jun 13. Review.
PMID: 16777485
Protease-activated receptor-2 activation: a major role in the pathogenesis of Porphyromonas gingivalis infection.
Holzhausen M, Spolidorio LC, Ellen RP, Jobin MC, Steinhoff M, Andrade-Gordon P, Vergnolle N.
Am J Pathol. 2006 Apr;168(4):1189-99.
PMID: 16565494 Free PMC Article
Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis.
Noorbakhsh F, Tsutsui S, Vergnolle N, Boven LA, Shariat N, Vodjgani M, Warren KG, Andrade-Gordon P, Hollenberg MD, Power C.
J Exp Med. 2006 Feb 20;203(2):425-35. Epub 2006 Feb 13.
PMID: 16476770 Free PMC Article
Functional characterization and expression analysis of the proteinase-activated receptor-2 in human cutaneous mast cells.
Moormann C, Artuc M, Pohl E, Varga G, Buddenkotte J, Vergnolle N, Brehler R, Henz BM, Schneider SW, Luger TA, Steinhoff M.
J Invest Dermatol. 2006 Apr;126(4):746-55.
PMID: 16470180 Free Article
Endogenous opioid-mediated antinociception in cholestatic mice is peripherally, not centrally, mediated.
Nelson L, Vergnolle N, D'Mello C, Chapman K, Le T, Swain MG.
J Hepatol. 2006 Jun;44(6):1141-9. Epub 2005 Dec 27.
PMID: 16466825
Neonatal immune challenge alters nociception in the adult rat.
Boissé L, Spencer SJ, Mouihate A, Vergnolle N, Pittman QJ.
Pain. 2005 Dec 15;119(1-3):133-41. Epub 2005 Nov 16.
PMID: 16297551
Proteinase-activated receptor-1 is an anti-inflammatory signal for colitis mediated by a type 2 immune response.
Cenac N, Cellars L, Steinhoff M, Andrade-Gordon P, Hollenberg MD, Wallace JL, Fiorucci S, Vergnolle N.
Inflamm Bowel Dis. 2005 Sep;11(9):792-8.
PMID: 16116312
Neutrophils and the kallikrein-kinin system in proteinase-activated receptor 4-mediated inflammation in rodents.
Houle S, Papez MD, Ferazzini M, Hollenberg MD, Vergnolle N.
Br J Pharmacol. 2005 Nov;146(5):670-8.
PMID: 16100525 Free PMC Article
Protease-activated receptors and inflammatory hyperalgesia.
Vergnolle N.
Mem Inst Oswaldo Cruz. 2005 Mar;100 Suppl 1:173-6. Epub 2005 Jun 14. Review.
PMID: 15962118 Free Article
A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis.
Hansen KK, Sherman PM, Cellars L, Andrade-Gordon P, Pan Z, Baruch A, Wallace JL, Hollenberg MD, Vergnolle N.
Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8363-8. Epub 2005 May 26.
PMID: 15919826 Free PMC Article
Proteinase-activated receptor-2 induction by neuroinflammation prevents neuronal death during HIV infection.
Noorbakhsh F, Vergnolle N, McArthur JC, Silva C, Vodjgani M, Andrade-Gordon P, Hollenberg MD, Power C.
J Immunol. 2005 Jun 1;174(11):7320-9.
PMID: 15905579 Free Article
Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis.
Chou MM, Vergnolle N, McDougall JJ, Wallace JL, Marty S, Teskey V, Buret AG.
Exp Biol Med (Maywood). 2005 Apr;230(4):255-62.
PMID: 15792947
Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response.
Steinhoff M, Buddenkotte J, Shpacovitch V, Rattenholl A, Moormann C, Vergnolle N, Luger TA, Hollenberg MD.
Endocr Rev. 2005 Feb;26(1):1-43. Review.
PMID: 15689571
Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B.
Buddenkotte J, Stroh C, Engels IH, Moormann C, Shpacovitch VM, Seeliger S, Vergnolle N, Vestweber D, Luger TA, Schulze-Osthoff K, Steinhoff M.
J Invest Dermatol. 2005 Jan;124(1):38-45.
PMID: 15654951 Free Article
A role for proteinase-activated receptor-1 in inflammatory bowel diseases.
Vergnolle N, Cellars L, Mencarelli A, Rizzo G, Swaminathan S, Beck P, Steinhoff M, Andrade-Gordon P, Bunnett NW, Hollenberg MD, Wallace JL, Cirino G, Fiorucci S.
J Clin Invest. 2004 Nov;114(10):1444-56. Retraction in: Vergnolle N, Cellars L, Mencarelli A, Rizzo G, Swaminathan S, Beck P, Steinhoff M, Andrade-Gordon P, Bunnett NW, Hollenberg MD, Wallace JL, Cirino G, Fiorucci S. J Clin Invest. 2006 Jul;116(7):2056.
PMID: 15545995 Free PMC Article
Annexin 1 is secreted in situ during ulcerative colitis in humans.
Vergnolle N, Pagès P, Guimbaud R, Chaussade S, Buéno L, Escourrou J, Coméra C.
Inflamm Bowel Dis. 2004 Sep;10(5):584-92.
PMID: 15472519
Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo.
Hollenberg MD, Saifeddine M, Sandhu S, Houle S, Vergnolle N.
Br J Pharmacol. 2004 Oct;143(4):443-54. Epub 2004 Sep 27.
PMID: 15451771 Free PMC Article
Activation of proteinase-activated receptor-1 inhibits neurally evoked chloride secretion in the mouse colon in vitro.
Buresi MC, Vergnolle N, Sharkey KA, Keenan CM, Andrade-Gordon P, Cirino G, Cirillo D, Hollenberg MD, MacNaughton WK.
Am J Physiol Gastrointest Liver Physiol. 2005 Feb;288(2):G337-45. Epub 2004 Sep 2.
PMID: 15345469 Free Article
Proteinase-activated receptor 2 activation modulates guinea-pig mesenteric lymphatic vessel pacemaker potential and contractile activity.
Chan AK, Vergnolle N, Hollenberg MD, von der Weid PY.
J Physiol. 2004 Oct 15;560(Pt 2):563-76. Epub 2004 Aug 26.
PMID: 15331674 Free PMC Article
Anti-inflammatory effects of nitric oxide-releasing hydrocortisone NCX 1022, in a murine model of contact dermatitis.
Hyun E, Bolla M, Steinhoff M, Wallace JL, Soldato PD, Vergnolle N.
Br J Pharmacol. 2004 Nov;143(5):618-25. Epub 2004 Aug 16.
PMID: 15313880 Free PMC Article
PAR2 activation alters colonic paracellular permeability in mice via IFN-gamma-dependent and -independent pathways.
Cenac N, Chin AC, Garcia-Villar R, Salvador-Cartier C, Ferrier L, Vergnolle N, Buret AG, Fioramonti J, Bueno L.
J Physiol. 2004 Aug 1;558(Pt 3):913-25. Epub 2004 Jun 11.
PMID: 15194744 Free PMC Article
Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.
Amadesi S, Nie J, Vergnolle N, Cottrell GS, Grady EF, Trevisani M, Manni C, Geppetti P, McRoberts JA, Ennes H, Davis JB, Mayer EA, Bunnett NW.
J Neurosci. 2004 May 5;24(18):4300-12.
PMID: 15128844 Free Article
Modulation of visceral pain and inflammation by protease-activated receptors.
Vergnolle N.
Br J Pharmacol. 2004 Apr;141(8):1264-74. Epub 2004 Mar 29. Review.
PMID: 15051630 Free PMC Article
Proteinase-activated receptors in the nervous system.
Noorbakhsh F, Vergnolle N, Hollenberg MD, Power C.
Nat Rev Neurosci. 2003 Dec;4(12):981-90. Review.
PMID: 14682360
Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism.
Nguyen C, Coelho AM, Grady E, Compton SJ, Wallace JL, Hollenberg MD, Cenac N, Garcia-Villar R, Bueno L, Steinhoff M, Bunnett NW, Vergnolle N.
Can J Physiol Pharmacol. 2003 Sep;81(9):920-7.
PMID: 14614531
The enteric nervous system in inflammation and pain: the role of proteinase-activated receptors.
Vergnolle N.
Can J Gastroenterol. 2003 Oct;17(10):589-92. Review.
Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo.
Seeliger S, Derian CK, Vergnolle N, Bunnett NW, Nawroth R, Schmelz M, Von Der Weid PY, Buddenkotte J, Sunderkötter C, Metze D, Andrade-Gordon P, Harms E, Vestweber D, Luger TA, Steinhoff M.
FASEB J. 2003 Oct;17(13):1871-85.
PMID: 14519665 Free Article
Proteinase-activated receptor 1 activation induces epithelial apoptosis and increases intestinal permeability.
Chin AC, Vergnolle N, MacNaughton WK, Wallace JL, Hollenberg MD, Buret AG.
Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11104-9. Epub 2003 Sep 5.
PMID: 12960392 Free PMC Article
Proteinase-activated receptors: novel signals for peripheral nerves.
Vergnolle N, Ferazzini M, D'Andrea MR, Buddenkotte J, Steinhoff M.
Trends Neurosci. 2003 Sep;26(9):496-500. Review.
PMID: 12948661
Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability.
Cenac N, Garcia-Villar R, Ferrier L, Larauche M, Vergnolle N, Bunnett NW, Coelho AM, Fioramonti J, Bueno L.
J Immunol. 2003 Apr 15;170(8):4296-300.
PMID: 12682265 Free Article
Up-regulation of proteinase-activated receptor 1 expression in astrocytes during HIV encephalitis.
Boven LA, Vergnolle N, Henry SD, Silva C, Imai Y, Holden J, Warren K, Hollenberg MD, Power C.
J Immunol. 2003 Mar 1;170(5):2638-46.
PMID: 12594292 Free Article
Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2.
Cenac N, Coelho AM, Nguyen C, Compton S, Andrade-Gordon P, MacNaughton WK, Wallace JL, Hollenberg MD, Bunnett NW, Garcia-Villar R, Bueno L, Vergnolle N.
Am J Pathol. 2002 Nov;161(5):1903-15.
PMID: 12414536 Free PMC Article
Characterization of thrombin-induced leukocyte rolling and adherence: a potential proinflammatory role for proteinase-activated receptor-4.
Vergnolle N, Derian CK, D'Andrea MR, Steinhoff M, Andrade-Gordon P.
J Immunol. 2002 Aug 1;169(3):1467-73.
PMID: 12133973 Free Article
Proteinases and proteinase-activated receptor 2: a possible role to promote visceral hyperalgesia in rats.
Coelho AM, Vergnolle N, Guiard B, Fioramonti J, Bueno L.
Gastroenterology. 2002 Apr;122(4):1035-47.
PMID: 11910355
Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli.
Asfaha S, Brussee V, Chapman K, Zochodne DW, Vergnolle N.
Br J Pharmacol. 2002 Mar;135(5):1101-6.
PMID: 11877315 Free PMC Article
PAR2-dependent activation of GSK3β regulates the survival of colon stem/progenitor cells.
Nasri I, Bonnet D, Zwarycz B, D'Aldebert E, Khou S, Mezghani-Jarraya R, Quaranta M, Rolland C, Bonnart C, Mas E, Ferrand A, Cenac N, Magness S, Van Landeghem L, Vergnolle N, Racaud-Sultan C.
Am J Physiol Gastrointest Liver Physiol. 2016 Jun 16:ajpgi.00328.2015. doi: 10.1152/ajpgi.00328.2015. [Epub ahead of print]
PMID: 27313176
Endogenous analgesia mediated by CD4(+) T lymphocytes is dependent on enkephalins in mice.
Basso L, Boué J, Mahiddine K, Blanpied C, Robiou-du-Pont S, Vergnolle N, Deraison C, Dietrich G.
J Neuroinflammation. 2016 Jun 1;13(1):132. doi: 10.1186/s12974-016-0591-x.
PMID: 27245576 Free PMC Article
Protease inhibition as new therapeutic strategy for GI diseases.
Vergnolle N.
Gut. 2016 Jul;65(7):1215-24. doi: 10.1136/gutjnl-2015-309147. Epub 2016 Apr 12. Review.
PMID: 27196587 Free PMC Article
The Intestinal Microenvironment and Functional Gastrointestinal Disorders.
Barbara G, Feinle-Bisset C, Ghoshal UC, Quigley EM, Santos J, Vanner S, Vergnolle N, Zoetendal EG.
Gastroenterology. 2016 Feb 18. pii: S0016-5085(16)00219-5. doi: 10.1053/j.gastro.2016.02.028. [Epub ahead of print]
PMID: 27144620
The arachidonic acid metabolite 11β-ProstaglandinF2α controls intestinal epithelial healing: deficiency in patients with Crohn's disease.
Coquenlorge S, Van Landeghem L, Jaulin J, Cenac N, Vergnolle N, Duchalais E, Neunlist M, Rolli-Derkinderen M.
Sci Rep. 2016 May 3;6:25203. doi: 10.1038/srep25203.
PMID: 27140063 Free PMC Article
Formyl Peptide Receptor 2 Plays a Deleterious Role During Influenza A Virus Infections.
Tcherniuk S, Cenac N, Comte M, Frouard J, Errazuriz-Cerda E, Galabov A, Morange PE, Vergnolle N, Si-Tahar M, Alessi MC, Riteau B.
J Infect Dis. 2016 Jul 15;214(2):237-47. doi: 10.1093/infdis/jiw127. Epub 2016 Mar 30.
PMID: 27034344
Sacral nerve stimulation enhances early intestinal mucosal repair following mucosal injury in a pig model.
Brégeon J, Coron E, Da Silva AC, Jaulin J, Aubert P, Chevalier J, Vergnolle N, Meurette G, Neunlist M.
J Physiol. 2016 Mar 4. doi: 10.1113/JP271783. [Epub ahead of print]
PMID: 26939757
Bladder telemetry: A new approach to evaluate micturition behavior under physiological and inflammatory conditions.
Monjotin N, Farrié M, Vergnolle N, Le Grand B, Gillespie J, Junquero D.
Neurourol Urodyn. 2016 Feb 16. doi: 10.1002/nau.22970. [Epub ahead of print]
PMID: 26879122
Reply.
Vergnolle N.
Gastroenterology. 2016 Mar;150(3):777-8. doi: 10.1053/j.gastro.2016.01.026. Epub 2016 Jan 29. No abstract available.
PMID: 26827802
Presence of commensal house dust mite allergen in human gastrointestinal tract: a potential contributor to intestinal barrier dysfunction.
Tulic MK, Vivinus-Nébot M, Rekima A, Rabelo Medeiros S, Bonnart C, Shi H, Walker A, Dainese R, Boyer J, Vergnolle N, Piche T, Verhasselt V.
Gut. 2016 May;65(5):757-66. doi: 10.1136/gutjnl-2015-310523. Epub 2015 Dec 8.
PMID: 26646935
Apelin targets gut contraction to control glucose metabolism via the brain.
Fournel A, Drougard A, Duparc T, Marlin A, Brierley SM, Castro J, Le-Gonidec S, Masri B, Colom A, Lucas A, Rousset P, Cenac N, Vergnolle N, Valet P, Cani PD, Knauf C.
Gut. 2015 Nov 12. pii: gutjnl-2015-310230. doi: 10.1136/gutjnl-2015-310230. [Epub ahead of print]
PMID: 26565000 Free Article
Defects in 15-HETE Production and Control of Epithelial Permeability by Human Enteric Glial Cells From Patients With Crohn's Disease.
Pochard C, Coquenlorge S, Jaulin J, Cenac N, Vergnolle N, Meurette G, Freyssinet M, Neunlist M, Rolli-Derkinderen M.
Gastroenterology. 2016 Jan;150(1):168-80. doi: 10.1053/j.gastro.2015.09.038. Epub 2015 Nov 11.
PMID: 26433161
TRPV1 sensitization mediates postinflammatory visceral pain following acute colitis.
Lapointe TK, Basso L, Iftinca MC, Flynn R, Chapman K, Dietrich G, Vergnolle N, Altier C.
Am J Physiol Gastrointest Liver Physiol. 2015 Jul 15;309(2):G87-99. doi: 10.1152/ajpgi.00421.2014. Epub 2015 May 28.
PMID: 26021808 Free Article
Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome.
Cenac N, Bautzova T, Le Faouder P, Veldhuis NA, Poole DP, Rolland C, Bertrand J, Liedtke W, Dubourdeau M, Bertrand-Michel J, Zecchi L, Stanghellini V, Bunnett NW, Barbara G, Vergnolle N.
Gastroenterology. 2015 Aug;149(2):433-44.e7. doi: 10.1053/j.gastro.2015.04.011. Epub 2015 Apr 22.
PMID: 25911511
Serine protease inhibitors protect better than IL-10 and TGF-β anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci.
Bermúdez-Humarán LG, Motta JP, Aubry C, Kharrat P, Rous-Martin L, Sallenave JM, Deraison C, Vergnolle N, Langella P.
Microb Cell Fact. 2015 Feb 26;14:26. doi: 10.1186/s12934-015-0198-4.
PMID: 25889561 Free PMC Article
Novel role of the serine protease inhibitor elafin in gluten-related disorders.
Galipeau HJ, Wiepjes M, Motta JP, Schulz JD, Jury J, Natividad JM, Pinto-Sanchez I, Sinclair D, Rousset P, Martin-Rosique R, Bermudez-Humaran L, Leroux JC, Murray JA, Smecuol E, Bai JC, Vergnolle N, Langella P, Verdu EF.
Am J Gastroenterol. 2014 May;109(5):748-56. doi: 10.1038/ajg.2014.48. Epub 2014 Apr 8.
PMID: 24710505 Free PMC Article
Activated protein C based therapeutic strategies in chronic diseases.
Bock F, Shahzad K, Vergnolle N, Isermann B.
Thromb Haemost. 2014 Apr 1;111(4):610-7. doi: 10.1160/TH13-11-0967. Epub 2014 Mar 20. Review.
PMID: 24652581
TRPV4: new therapeutic target for inflammatory bowel diseases.
Vergnolle N.
Biochem Pharmacol. 2014 May 15;89(2):157-61. doi: 10.1016/j.bcp.2014.01.005. Epub 2014 Jan 16. Review.
PMID: 24440740
Polyunsaturated fatty acid metabolism signature in ischemia differs from reperfusion in mouse intestine.
Gobbetti T, Le Faouder P, Bertrand J, Dubourdeau M, Barocelli E, Cenac N, Vergnolle N.
PLoS One. 2013 Sep 20;8(9):e75581. doi: 10.1371/journal.pone.0075581. eCollection 2013.
PMID: 24073272 Free PMC Article
Endogenous regulation of visceral pain via production of opioids by colitogenic CD4(+) T cells in mice.
Boué J, Basso L, Cenac N, Blanpied C, Rolli-Derkinderen M, Neunlist M, Vergnolle N, Dietrich G.
Gastroenterology. 2014 Jan;146(1):166-75. doi: 10.1053/j.gastro.2013.09.020. Epub 2013 Sep 18.
PMID: 24055279
Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model.
Aerts L, Hamelin MÈ, Rhéaume C, Lavigne S, Couture C, Kim W, Susan-Resiga D, Prat A, Seidah NG, Vergnolle N, Riteau B, Boivin G.
PLoS One. 2013 Aug 28;8(8):e72529. doi: 10.1371/journal.pone.0072529. eCollection 2013.
PMID: 24015257 Free PMC Article
Engineering lactococci and lactobacilli for human health.
Bermúdez-Humarán LG, Aubry C, Motta JP, Deraison C, Steidler L, Vergnolle N, Chatel JM, Langella P.
Curr Opin Microbiol. 2013 Jun;16(3):278-83. doi: 10.1016/j.mib.2013.06.002. Epub 2013 Jul 11. Review.
PMID: 23850097
LC-MS/MS method for rapid and concomitant quantification of pro-inflammatory and pro-resolving polyunsaturated fatty acid metabolites.
Le Faouder P, Baillif V, Spreadbury I, Motta JP, Rousset P, Chêne G, Guigné C, Tercé F, Vanner S, Vergnolle N, Bertrand-Michel J, Dubourdeau M, Cenac N.
J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Aug 1;932:123-33. doi: 10.1016/j.jchromb.2013.06.014. Epub 2013 Jun 15.
PMID: 23831705
A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation.
Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S, Perretti M.
Blood. 2013 Jul 25;122(4):608-17. doi: 10.1182/blood-2013-04-496661. Epub 2013 Jun 3.
PMID: 23733341 Free PMC Article
Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update.
LeBlanc JG, Aubry C, Cortes-Perez NG, de Moreno de LeBlanc A, Vergnolle N, Langella P, Azevedo V, Chatel JM, Miyoshi A, Bermúdez-Humarán LG.
FEMS Microbiol Lett. 2013 Jul;344(1):1-9. doi: 10.1111/1574-6968.12159. Epub 2013 May 16. Review.
PMID: 23600579 Free Article
TRPM8 activation attenuates inflammatory responses in mouse models of colitis.
Ramachandran R, Hyun E, Zhao L, Lapointe TK, Chapman K, Hirota CL, Ghosh S, McKemy DD, Vergnolle N, Beck PL, Altier C, Hollenberg MD.
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7476-81. doi: 10.1073/pnas.1217431110. Epub 2013 Apr 17.
PMID: 23596210 Free PMC Article
Relevance of the cyclophosphamide-induced cystitis model for pharmacological studies targeting inflammation and pain of the bladder.
Augé C, Chene G, Dubourdeau M, Desoubzdanne D, Corman B, Palea S, Lluel P, Vergnolle N, Coelho AM.
Eur J Pharmacol. 2013 May 5;707(1-3):32-40. doi: 10.1016/j.ejphar.2013.03.008. Epub 2013 Mar 26.
PMID: 23541724
New neostigmine-based behavioral mouse model of abdominal pain.
Fichna J, Lapointe T, Chapman K, Janecka A, Vergnolle N, Altier C, Storr MA.
Pharmacol Rep. 2012;64(5):1146-54.
PMID: 23238471 Free Article
Food-grade bacteria expressing elafin protect against inflammation and restore colon homeostasis.
Motta JP, Bermúdez-Humarán LG, Deraison C, Martin L, Rolland C, Rousset P, Boue J, Dietrich G, Chapman K, Kharrat P, Vinel JP, Alric L, Mas E, Sallenave JM, Langella P, Vergnolle N.
Sci Transl Med. 2012 Oct 31;4(158):158ra144. doi: 10.1126/scitranslmed.3004212.
PMID: 23115353 Free Article
Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling.
Despeaux M, Chicanne G, Rouer E, De Toni-Costes F, Bertrand J, Mansat-De Mas V, Vergnolle N, Eaves C, Payrastre B, Girault JA, Racaud-Sultan C.
Stem Cells. 2012 Aug;30(8):1597-610. doi: 10.1002/stem.1157.
PMID: 22714993 Free Article
A spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease.
Chabod M, Pedros C, Lamouroux L, Colacios C, Bernard I, Lagrange D, Balz-Hara D, Mosnier JF, Laboisse C, Vergnolle N, Andreoletti O, Roth MP, Liblau R, Fournié GJ, Saoudi A, Dejean AS.
PLoS Genet. 2012 Jan;8(1):e1002461. doi: 10.1371/journal.pgen.1002461. Epub 2012 Jan 19.
PMID: 22275874 Free PMC Article
Immune conditions associated with CD4+ T effector-induced opioid release and analgesia.
Boué J, Blanpied C, Djata-Cabral M, Pelletier L, Vergnolle N, Dietrich G.
Pain. 2012 Feb;153(2):485-93. doi: 10.1016/j.pain.2011.11.013. Epub 2011 Dec 19.
PMID: 22188867
Role of transient receptor potential vanilloid 4 in rat joint inflammation.
Denadai-Souza A, Martin L, de Paula MA, de Avellar MC, Muscará MN, Vergnolle N, Cenac N.
Arthritis Rheum. 2012 Jun;64(6):1848-58. doi: 10.1002/art.34345. Epub 2011 Dec 19.
PMID: 22184014 Free Article
Serine protease inhibition reduces post-ischemic granulocyte recruitment in mouse intestine.
Gobbetti T, Cenac N, Motta JP, Rolland C, Martin L, Andrade-Gordon P, Steinhoff M, Barocelli E, Vergnolle N.
Am J Pathol. 2012 Jan;180(1):141-52. doi: 10.1016/j.ajpath.2011.09.031. Epub 2011 Nov 7.
PMID: 22067907
Mechanisms behind the anti-inflammatory actions of insulin.
Hyun E, Ramachandran R, Hollenberg MD, Vergnolle N.
Crit Rev Immunol. 2011;31(4):307-40. Review.
PMID: 21899513
Brain-gut interactions increase peripheral nociceptive signaling in mice with postinfectious irritable bowel syndrome.
Ibeakanma C, Ochoa-Cortes F, Miranda-Morales M, McDonald T, Spreadbury I, Cenac N, Cattaruzza F, Hurlbut D, Vanner S, Bunnett N, Vergnolle N, Vanner S.
Gastroenterology. 2011 Dec;141(6):2098-2108.e5. doi: 10.1053/j.gastro.2011.08.006. Epub 2011 Aug 19.
PMID: 21856270
Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferon-γ on human neutrophils and monocytes.
Shpacovitch VM, Feld M, Holzinger D, Kido M, Hollenberg MD, Levi-Schaffer F, Vergnolle N, Ludwig S, Roth J, Luger T, Steinhoff M.
Immunology. 2011 Jul;133(3):329-39. doi: 10.1111/j.1365-2567.2011.03443.x. Epub 2011 Apr 19.
PMID: 21501162 Free PMC Article
Endogenous opioid-mediated analgesia is dependent on adaptive T cell response in mice.
Boué J, Blanpied C, Brousset P, Vergnolle N, Dietrich G.
J Immunol. 2011 May 1;186(9):5078-84. doi: 10.4049/jimmunol.1003335. Epub 2011 Mar 21.
PMID: 21422247 Free Article
Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.
Motta JP, Magne L, Descamps D, Rolland C, Squarzoni-Dale C, Rousset P, Martin L, Cenac N, Balloy V, Huerre M, Fröhlich LF, Jenne D, Wartelle J, Belaaouaj A, Mas E, Vinel JP, Alric L, Chignard M, Vergnolle N, Sallenave JM.
Gastroenterology. 2011 Apr;140(4):1272-82. doi: 10.1053/j.gastro.2010.12.050. Epub 2011 Jan 1.
PMID: 21199654
Transient receptor potential vanilloid 4 activated inflammatory signals by intestinal epithelial cells and colitis in mice.
D'Aldebert E, Cenac N, Rousset P, Martin L, Rolland C, Chapman K, Selves J, Alric L, Vinel JP, Vergnolle N.
Gastroenterology. 2011 Jan;140(1):275-85. doi: 10.1053/j.gastro.2010.09.045. Epub 2010 Oct 1.
PMID: 20888819
Contribution of bone marrow-derived cells to the pro-inflammatory effects of protease-activated receptor-2 in colitis.
Hyun E, Andrade-Gordon P, Steinhoff M, Beck PL, Vergnolle N.
Inflamm Res. 2010 Sep;59(9):699-709. doi: 10.1007/s00011-010-0181-9. Epub 2010 Mar 26.
PMID: 20339899 Free PMC Article
Potentiation of TRPV4 signalling by histamine and serotonin: an important mechanism for visceral hypersensitivity.
Cenac N, Altier C, Motta JP, d'Aldebert E, Galeano S, Zamponi GW, Vergnolle N.
Gut. 2010 Apr;59(4):481-8. doi: 10.1136/gut.2009.192567.
PMID: 20332520
Insulin modulates protease-activated receptor 2 signaling: implications for the innate immune response.
Hyun E, Ramachandran R, Cenac N, Houle S, Rousset P, Saxena A, Liblau RS, Hollenberg MD, Vergnolle N.
J Immunol. 2010 Mar 1;184(5):2702-9. doi: 10.4049/jimmunol.0902171. Epub 2010 Jan 29.
PMID: 20118282 Free Article
Thrombin receptor: An endogenous inhibitor of inflammatory pain, activating opioid pathways.
Martin L, Augé C, Boué J, Buresi MC, Chapman K, Asfaha S, Andrade-Gordon P, Steinhoff M, Cenac N, Dietrich G, Vergnolle N.
Pain. 2009 Nov;146(1-2):121-9. doi: 10.1016/j.pain.2009.07.016. Epub 2009 Aug 11.
PMID: 19674841
Visceral afferents: what role in post-inflammatory pain?
Vergnolle N.
Auton Neurosci. 2010 Feb 16;153(1-2):79-83. doi: 10.1016/j.autneu.2009.07.015. Epub 2009 Aug 9. Review.
PMID: 19666242
Analgesic properties of S100A9 C-terminal domain: a mechanism dependent on calcium channel inhibition.
Dale CS, Altier C, Cenac N, Giorgi R, Juliano MA, Juliano L, Zamponi GW, Vergnolle N.
Fundam Clin Pharmacol. 2009 Aug;23(4):427-38. doi: 10.1111/j.1472-8206.2009.00686.x. Epub 2009 Jun 8.
PMID: 19515068
Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway.
Khoufache K, LeBouder F, Morello E, Laurent F, Riffault S, Andrade-Gordon P, Boullier S, Rousset P, Vergnolle N, Riteau B.
J Immunol. 2009 Jun 15;182(12):7795-802. doi: 10.4049/jimmunol.0803743.
PMID: 19494303 Free Article
Protease-activated receptors as drug targets in inflammation and pain.
Vergnolle N.
Pharmacol Ther. 2009 Sep;123(3):292-309. doi: 10.1016/j.pharmthera.2009.05.004. Epub 2009 May 28. Review.
PMID: 19481569
Triggering of proteinase-activated receptor 4 leads to joint pain and inflammation in mice.
McDougall JJ, Zhang C, Cellars L, Joubert E, Dixon CM, Vergnolle N.
Arthritis Rheum. 2009 Mar;60(3):728-37. doi: 10.1002/art.24300.
PMID: 19248120 Free Article
Development, plasticity and modulation of visceral afferents.
Christianson JA, Bielefeldt K, Altier C, Cenac N, Davis BM, Gebhart GF, High KW, Kollarik M, Randich A, Undem B, Vergnolle N.
Brain Res Rev. 2009 Apr;60(1):171-86. doi: 10.1016/j.brainresrev.2008.12.004. Epub 2008 Dec 25. Review.
PMID: 19150371 Free PMC Article
Neutrophil-mediated activation of epithelial protease-activated receptors-1 and -2 regulates barrier function and transepithelial migration.
Chin AC, Lee WY, Nusrat A, Vergnolle N, Parkos CA.
J Immunol. 2008 Oct 15;181(8):5702-10.
PMID: 18832729 Free PMC Article
Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms.
Cenac N, Altier C, Chapman K, Liedtke W, Zamponi G, Vergnolle N.
Gastroenterology. 2008 Sep;135(3):937-46, 946.e1-2. doi: 10.1053/j.gastro.2008.05.024. Epub 2008 May 10.
PMID: 18565335
Derivatized 2-furoyl-LIGRLO-amide, a versatile and selective probe for proteinase-activated receptor 2: binding and visualization.
Hollenberg MD, Renaux B, Hyun E, Houle S, Vergnolle N, Saifeddine M, Ramachandran R.
J Pharmacol Exp Ther. 2008 Aug;326(2):453-62. doi: 10.1124/jpet.108.136432. Epub 2008 May 13.
PMID: 18477767 Free Article
Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection.
Feld M, Shpacovitch VM, Ehrhardt C, Kerkhoff C, Hollenberg MD, Vergnolle N, Ludwig S, Steinhoff M.
J Immunol. 2008 May 15;180(10):6903-10.
PMID: 18453611 Free Article
Protease signaling to G protein-coupled receptors: implications for inflammation and pain.
Dale C, Vergnolle N.
J Recept Signal Transduct Res. 2008;28(1-2):29-37. doi: 10.1080/10799890801941913 . Review.
PMID: 18437628
Proteinase-activated receptors (PARs) in infection and inflammation in the gut.
Vergnolle N.
Int J Biochem Cell Biol. 2008;40(6-7):1219-27. doi: 10.1016/j.biocel.2008.01.016. Epub 2008 Jan 20. Review.
PMID: 18313348
Mechanisms underlying the nociceptive and inflammatory responses induced by trypsin in the mouse paw.
Paszcuk AF, Quintão NL, Fernandes ES, Juliano L, Chapman K, Andrade-Gordon P, Campos MM, Vergnolle N, Calixto JB.
Eur J Pharmacol. 2008 Feb 26;581(1-2):204-15. Epub 2007 Nov 23.
PMID: 18083162
Intrathecal administration of proteinase-activated receptor-2 agonists produces hyperalgesia by exciting the cell bodies of primary sensory neurons.
Alier KA, Endicott JA, Stemkowski PL, Cenac N, Cellars L, Chapman K, Andrade-Gordon P, Vergnolle N, Smith PA.
J Pharmacol Exp Ther. 2008 Jan;324(1):224-33. Epub 2007 Oct 5.
PMID: 17921188 Free Article
Proteinase-activated receptor-2 exerts protective and pathogenic cell type-specific effects in Alzheimer's disease.
Afkhami-Goli A, Noorbakhsh F, Keller AJ, Vergnolle N, Westaway D, Jhamandas JH, Andrade-Gordon P, Hollenberg MD, Arab H, Dyck RH, Power C.
J Immunol. 2007 Oct 15;179(8):5493-503.
PMID: 17911636 Free Article
Agonists of proteinase-activated receptor-2 affect transendothelial migration and apoptosis of human neutrophils.
Shpacovitch VM, Seeliger S, Huber-Lang M, Balkow S, Feld M, Hollenberg MD, Sarma VJ, Ward PA, Strey A, Gerke V, Sommerhoff CP, Vergnolle N, Steinhoff M.
Exp Dermatol. 2007 Oct;16(10):799-806.
PMID: 17845211
Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia.
Knecht W, Cottrell GS, Amadesi S, Mohlin J, Skåregärde A, Gedda K, Peterson A, Chapman K, Hollenberg MD, Vergnolle N, Bunnett NW.
J Biol Chem. 2007 Sep 7;282(36):26089-100. Epub 2007 Jul 10.
PMID: 17623652 Free Article
Differential role of N-type calcium channel splice isoforms in pain.
Altier C, Dale CS, Kisilevsky AE, Chapman K, Castiglioni AJ, Matthews EA, Evans RM, Dickenson AH, Lipscombe D, Vergnolle N, Zamponi GW.
J Neurosci. 2007 Jun 13;27(24):6363-73.
PMID: 17567797 Free Article
Citrobacter rodentium infection causes iNOS-independent intestinal epithelial dysfunction in mice.
Skinn AC, Vergnolle N, Zamuner SR, Wallace JL, Cellars L, MacNaughton WK, Sherman PM.
Can J Physiol Pharmacol. 2006 Dec;84(12):1301-12.
PMID: 17487239
Proteinase-activated receptor-2 (PAR2): a tumor suppressor in skin carcinogenesis.
Rattenholl A, Seeliger S, Buddenkotte J, Schön M, Schön MP, Ständer S, Vergnolle N, Steinhoff M.
J Invest Dermatol. 2007 Sep;127(9):2245-52. Epub 2007 May 3.
PMID: 17476297 Free Article
Role for protease activity in visceral pain in irritable bowel syndrome.
Cenac N, Andrews CN, Holzhausen M, Chapman K, Cottrell G, Andrade-Gordon P, Steinhoff M, Barbara G, Beck P, Bunnett NW, Sharkey KA, Ferraz JG, Shaffer E, Vergnolle N.
J Clin Invest. 2007 Mar;117(3):636-47. Epub 2007 Feb 15.
PMID: 17304351 Free PMC Article
Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice.
Grant AD, Cottrell GS, Amadesi S, Trevisani M, Nicoletti P, Materazzi S, Altier C, Cenac N, Zamponi GW, Bautista-Cruz F, Lopez CB, Joseph EK, Levine JD, Liedtke W, Vanner S, Vergnolle N, Geppetti P, Bunnett NW.
J Physiol. 2007 Feb 1;578(Pt 3):715-33. Epub 2006 Nov 23.
PMID: 17124270 Free PMC Article
A role for proteinase-activated receptor-1 in inflammatory bowel diseases.
Vergnolle N, Cellars L, Mencarelli A, Rizzo G, Swaminathan S, Beck P, Steinhoff M, Andrade-Gordon P, Bunnett NW, Hollenberg MD, Wallace JL, Cirino G, Fiorucci S.
J Clin Invest. 2006 Jul;116(7):2056. No abstract available.
PMID: 16881139 Free PMC Article
Protective effect of proteinase-activated receptor 2 activation on motility impairment and tissue damage induced by intestinal ischemia/reperfusion in rodents.
Cattaruzza F, Cenac N, Barocelli E, Impicciatore M, Hyun E, Vergnolle N, Sternini C.
Am J Pathol. 2006 Jul;169(1):177-88.
PMID: 16816371 Free PMC Article
Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs).
Oikonomopoulou K, Hansen KK, Saifeddine M, Vergnolle N, Tea I, Blaber M, Blaber SI, Scarisbrick I, Diamandis EP, Hollenberg MD.
Biol Chem. 2006 Jun;387(6):817-24.
PMID: 16800746
Proteinase-mediated cell signalling: targeting proteinase-activated receptors (PARs) by kallikreins and more.
Oikonomopoulou K, Hansen KK, Saifeddine M, Vergnolle N, Tea I, Diamandis EP, Hollenberg MD.
Biol Chem. 2006 Jun;387(6):677-85. Review.
PMID: 16800728
Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice.
Amadesi S, Cottrell GS, Divino L, Chapman K, Grady EF, Bautista F, Karanjia R, Barajas-Lopez C, Vanner S, Vergnolle N, Bunnett NW.
J Physiol. 2006 Sep 1;575(Pt 2):555-71. Epub 2006 Jun 22.
PMID: 16793902 Free PMC Article
Proteinase-activated receptors (PARs): crossroads between innate immunity and coagulation.
Cirino G, Vergnolle N.
Curr Opin Pharmacol. 2006 Aug;6(4):428-34. Epub 2006 Jun 13. Review.
PMID: 16777485
Protease-activated receptor-2 activation: a major role in the pathogenesis of Porphyromonas gingivalis infection.
Holzhausen M, Spolidorio LC, Ellen RP, Jobin MC, Steinhoff M, Andrade-Gordon P, Vergnolle N.
Am J Pathol. 2006 Apr;168(4):1189-99.
PMID: 16565494 Free PMC Article
Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis.
Noorbakhsh F, Tsutsui S, Vergnolle N, Boven LA, Shariat N, Vodjgani M, Warren KG, Andrade-Gordon P, Hollenberg MD, Power C.
J Exp Med. 2006 Feb 20;203(2):425-35. Epub 2006 Feb 13.
PMID: 16476770 Free PMC Article
Functional characterization and expression analysis of the proteinase-activated receptor-2 in human cutaneous mast cells.
Moormann C, Artuc M, Pohl E, Varga G, Buddenkotte J, Vergnolle N, Brehler R, Henz BM, Schneider SW, Luger TA, Steinhoff M.
J Invest Dermatol. 2006 Apr;126(4):746-55.
PMID: 16470180 Free Article
Endogenous opioid-mediated antinociception in cholestatic mice is peripherally, not centrally, mediated.
Nelson L, Vergnolle N, D'Mello C, Chapman K, Le T, Swain MG.
J Hepatol. 2006 Jun;44(6):1141-9. Epub 2005 Dec 27.
PMID: 16466825
Neonatal immune challenge alters nociception in the adult rat.
Boissé L, Spencer SJ, Mouihate A, Vergnolle N, Pittman QJ.
Pain. 2005 Dec 15;119(1-3):133-41. Epub 2005 Nov 16.
PMID: 16297551
Proteinase-activated receptor-1 is an anti-inflammatory signal for colitis mediated by a type 2 immune response.
Cenac N, Cellars L, Steinhoff M, Andrade-Gordon P, Hollenberg MD, Wallace JL, Fiorucci S, Vergnolle N.
Inflamm Bowel Dis. 2005 Sep;11(9):792-8.
PMID: 16116312
Neutrophils and the kallikrein-kinin system in proteinase-activated receptor 4-mediated inflammation in rodents.
Houle S, Papez MD, Ferazzini M, Hollenberg MD, Vergnolle N.
Br J Pharmacol. 2005 Nov;146(5):670-8.
PMID: 16100525 Free PMC Article
Protease-activated receptors and inflammatory hyperalgesia.
Vergnolle N.
Mem Inst Oswaldo Cruz. 2005 Mar;100 Suppl 1:173-6. Epub 2005 Jun 14. Review.
PMID: 15962118 Free Article
A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis.
Hansen KK, Sherman PM, Cellars L, Andrade-Gordon P, Pan Z, Baruch A, Wallace JL, Hollenberg MD, Vergnolle N.
Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8363-8. Epub 2005 May 26.
PMID: 15919826 Free PMC Article
Proteinase-activated receptor-2 induction by neuroinflammation prevents neuronal death during HIV infection.
Noorbakhsh F, Vergnolle N, McArthur JC, Silva C, Vodjgani M, Andrade-Gordon P, Hollenberg MD, Power C.
J Immunol. 2005 Jun 1;174(11):7320-9.
PMID: 15905579 Free Article
Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis.
Chou MM, Vergnolle N, McDougall JJ, Wallace JL, Marty S, Teskey V, Buret AG.
Exp Biol Med (Maywood). 2005 Apr;230(4):255-62.
PMID: 15792947
Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response.
Steinhoff M, Buddenkotte J, Shpacovitch V, Rattenholl A, Moormann C, Vergnolle N, Luger TA, Hollenberg MD.
Endocr Rev. 2005 Feb;26(1):1-43. Review.
PMID: 15689571
Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B.
Buddenkotte J, Stroh C, Engels IH, Moormann C, Shpacovitch VM, Seeliger S, Vergnolle N, Vestweber D, Luger TA, Schulze-Osthoff K, Steinhoff M.
J Invest Dermatol. 2005 Jan;124(1):38-45.
PMID: 15654951 Free Article
A role for proteinase-activated receptor-1 in inflammatory bowel diseases.
Vergnolle N, Cellars L, Mencarelli A, Rizzo G, Swaminathan S, Beck P, Steinhoff M, Andrade-Gordon P, Bunnett NW, Hollenberg MD, Wallace JL, Cirino G, Fiorucci S.
J Clin Invest. 2004 Nov;114(10):1444-56. Retraction in: Vergnolle N, Cellars L, Mencarelli A, Rizzo G, Swaminathan S, Beck P, Steinhoff M, Andrade-Gordon P, Bunnett NW, Hollenberg MD, Wallace JL, Cirino G, Fiorucci S. J Clin Invest. 2006 Jul;116(7):2056.
PMID: 15545995 Free PMC Article
Annexin 1 is secreted in situ during ulcerative colitis in humans.
Vergnolle N, Pagès P, Guimbaud R, Chaussade S, Buéno L, Escourrou J, Coméra C.
Inflamm Bowel Dis. 2004 Sep;10(5):584-92.
PMID: 15472519
Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo.
Hollenberg MD, Saifeddine M, Sandhu S, Houle S, Vergnolle N.
Br J Pharmacol. 2004 Oct;143(4):443-54. Epub 2004 Sep 27.
PMID: 15451771 Free PMC Article
Activation of proteinase-activated receptor-1 inhibits neurally evoked chloride secretion in the mouse colon in vitro.
Buresi MC, Vergnolle N, Sharkey KA, Keenan CM, Andrade-Gordon P, Cirino G, Cirillo D, Hollenberg MD, MacNaughton WK.
Am J Physiol Gastrointest Liver Physiol. 2005 Feb;288(2):G337-45. Epub 2004 Sep 2.
PMID: 15345469 Free Article
Proteinase-activated receptor 2 activation modulates guinea-pig mesenteric lymphatic vessel pacemaker potential and contractile activity.
Chan AK, Vergnolle N, Hollenberg MD, von der Weid PY.
J Physiol. 2004 Oct 15;560(Pt 2):563-76. Epub 2004 Aug 26.
PMID: 15331674 Free PMC Article
Anti-inflammatory effects of nitric oxide-releasing hydrocortisone NCX 1022, in a murine model of contact dermatitis.
Hyun E, Bolla M, Steinhoff M, Wallace JL, Soldato PD, Vergnolle N.
Br J Pharmacol. 2004 Nov;143(5):618-25. Epub 2004 Aug 16.
PMID: 15313880 Free PMC Article
PAR2 activation alters colonic paracellular permeability in mice via IFN-gamma-dependent and -independent pathways.
Cenac N, Chin AC, Garcia-Villar R, Salvador-Cartier C, Ferrier L, Vergnolle N, Buret AG, Fioramonti J, Bueno L.
J Physiol. 2004 Aug 1;558(Pt 3):913-25. Epub 2004 Jun 11.
PMID: 15194744 Free PMC Article
Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.
Amadesi S, Nie J, Vergnolle N, Cottrell GS, Grady EF, Trevisani M, Manni C, Geppetti P, McRoberts JA, Ennes H, Davis JB, Mayer EA, Bunnett NW.
J Neurosci. 2004 May 5;24(18):4300-12.
PMID: 15128844 Free Article
Modulation of visceral pain and inflammation by protease-activated receptors.
Vergnolle N.
Br J Pharmacol. 2004 Apr;141(8):1264-74. Epub 2004 Mar 29. Review.
PMID: 15051630 Free PMC Article
Proteinase-activated receptors in the nervous system.
Noorbakhsh F, Vergnolle N, Hollenberg MD, Power C.
Nat Rev Neurosci. 2003 Dec;4(12):981-90. Review.
PMID: 14682360
Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism.
Nguyen C, Coelho AM, Grady E, Compton SJ, Wallace JL, Hollenberg MD, Cenac N, Garcia-Villar R, Bueno L, Steinhoff M, Bunnett NW, Vergnolle N.
Can J Physiol Pharmacol. 2003 Sep;81(9):920-7.
PMID: 14614531
The enteric nervous system in inflammation and pain: the role of proteinase-activated receptors.
Vergnolle N.
Can J Gastroenterol. 2003 Oct;17(10):589-92. Review.
PMID: 14571293
Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo.
Seeliger S, Derian CK, Vergnolle N, Bunnett NW, Nawroth R, Schmelz M, Von Der Weid PY, Buddenkotte J, Sunderkötter C, Metze D, Andrade-Gordon P, Harms E, Vestweber D, Luger TA, Steinhoff M.
FASEB J. 2003 Oct;17(13):1871-85.
PMID: 14519665 Free Article
Proteinase-activated receptor 1 activation induces epithelial apoptosis and increases intestinal permeability.
Chin AC, Vergnolle N, MacNaughton WK, Wallace JL, Hollenberg MD, Buret AG.
Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11104-9. Epub 2003 Sep 5.
PMID: 12960392 Free PMC Article
Proteinase-activated receptors: novel signals for peripheral nerves.
Vergnolle N, Ferazzini M, D'Andrea MR, Buddenkotte J, Steinhoff M.
Trends Neurosci. 2003 Sep;26(9):496-500. Review.
PMID: 12948661
Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability.
Cenac N, Garcia-Villar R, Ferrier L, Larauche M, Vergnolle N, Bunnett NW, Coelho AM, Fioramonti J, Bueno L.
J Immunol. 2003 Apr 15;170(8):4296-300.
PMID: 12682265 Free Article
Up-regulation of proteinase-activated receptor 1 expression in astrocytes during HIV encephalitis.
Boven LA, Vergnolle N, Henry SD, Silva C, Imai Y, Holden J, Warren K, Hollenberg MD, Power C.
J Immunol. 2003 Mar 1;170(5):2638-46.
PMID: 12594292 Free Article
Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2.
Cenac N, Coelho AM, Nguyen C, Compton S, Andrade-Gordon P, MacNaughton WK, Wallace JL, Hollenberg MD, Bunnett NW, Garcia-Villar R, Bueno L, Vergnolle N.
Am J Pathol. 2002 Nov;161(5):1903-15.
PMID: 12414536 Free PMC Article
Characterization of thrombin-induced leukocyte rolling and adherence: a potential proinflammatory role for proteinase-activated receptor-4.
Vergnolle N, Derian CK, D'Andrea MR, Steinhoff M, Andrade-Gordon P.
J Immunol. 2002 Aug 1;169(3):1467-73.
PMID: 12133973 Free Article
Proteinases and proteinase-activated receptor 2: a possible role to promote visceral hyperalgesia in rats.
Coelho AM, Vergnolle N, Guiard B, Fioramonti J, Bueno L.
Gastroenterology. 2002 Apr;122(4):1035-47.
PMID: 11910355
Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli.
Asfaha S, Brussee V, Chapman K, Zochodne DW, Vergnolle N.
Br J Pharmacol. 2002 Mar;135(5):1101-6.
PMID: 11877315 Free PMC Article
Nasri I, Bonnet D, Zwarycz B, D'Aldebert E, Khou S, Mezghani-Jarraya R, Quaranta M, Rolland C, Bonnart C, Mas E, Ferrand A, Cenac N, Magness S, Van Landeghem L, Vergnolle N, Racaud-Sultan C.
Am J Physiol Gastrointest Liver Physiol. 2016 Jun 16:ajpgi.00328.2015. doi: 10.1152/ajpgi.00328.2015.
[Epub ahead of print]
Endogenous analgesia mediated by CD4(+) T lymphocytes is dependent on enkephalins in mice.
Basso L, Boué J, Mahiddine K, Blanpied C, Robiou-du-Pont S, Vergnolle N, Deraison C, Dietrich G.
J Neuroinflammation. 2016 Jun 1;13(1):132. doi: 10.1186/s12974-016-0591-x.
PMID: 27245576 Free PMC Article
Protease inhibition as new therapeutic strategy for GI diseases.
Vergnolle N.
Gut. 2016 Jul;65(7):1215-24. doi: 10.1136/gutjnl-2015-309147. Epub 2016 Apr 12. Review.
PMID: 27196587 Free PMC Article
The Intestinal Microenvironment and Functional Gastrointestinal Disorders.
Barbara G, Feinle-Bisset C, Ghoshal UC, Quigley EM, Santos J, Vanner S, Vergnolle N, Zoetendal EG.
Gastroenterology. 2016 Feb 18. pii: S0016-5085(16)00219-5. doi: 10.1053/j.gastro.2016.02.028. [Epub ahead of print]
PMID: 27144620
The arachidonic acid metabolite 11β-ProstaglandinF2α controls intestinal epithelial healing: deficiency in patients with Crohn's disease.
Coquenlorge S, Van Landeghem L, Jaulin J, Cenac N, Vergnolle N, Duchalais E, Neunlist M, Rolli-Derkinderen M.
Sci Rep. 2016 May 3;6:25203. doi: 10.1038/srep25203.
PMID: 27140063 Free PMC Article
Formyl Peptide Receptor 2 Plays a Deleterious Role During Influenza A Virus Infections.
Tcherniuk S, Cenac N, Comte M, Frouard J, Errazuriz-Cerda E, Galabov A, Morange PE, Vergnolle N, Si-Tahar M, Alessi MC, Riteau B.
J Infect Dis. 2016 Jul 15;214(2):237-47. doi: 10.1093/infdis/jiw127. Epub 2016 Mar 30.
PMID: 27034344
Sacral nerve stimulation enhances early intestinal mucosal repair following mucosal injury in a pig model.
Brégeon J, Coron E, Da Silva AC, Jaulin J, Aubert P, Chevalier J, Vergnolle N, Meurette G, Neunlist M.
J Physiol. 2016 Mar 4. doi: 10.1113/JP271783. [Epub ahead of print]
PMID: 26939757
Bladder telemetry: A new approach to evaluate micturition behavior under physiological and inflammatory conditions.
Monjotin N, Farrié M, Vergnolle N, Le Grand B, Gillespie J, Junquero D.
Neurourol Urodyn. 2016 Feb 16. doi: 10.1002/nau.22970. [Epub ahead of print]
PMID: 26879122
Reply.
Vergnolle N.
Gastroenterology. 2016 Mar;150(3):777-8. doi: 10.1053/j.gastro.2016.01.026. Epub 2016 Jan 29. No abstract available.
PMID: 26827802
Presence of commensal house dust mite allergen in human gastrointestinal tract: a potential contributor to intestinal barrier dysfunction.
Tulic MK, Vivinus-Nébot M, Rekima A, Rabelo Medeiros S, Bonnart C, Shi H, Walker A, Dainese R, Boyer J, Vergnolle N, Piche T, Verhasselt V.
Gut. 2016 May;65(5):757-66. doi: 10.1136/gutjnl-2015-310523. Epub 2015 Dec 8.
PMID: 26646935
Apelin targets gut contraction to control glucose metabolism via the brain.
Fournel A, Drougard A, Duparc T, Marlin A, Brierley SM, Castro J, Le-Gonidec S, Masri B, Colom A, Lucas A, Rousset P, Cenac N, Vergnolle N, Valet P, Cani PD, Knauf C.
Gut. 2015 Nov 12. pii: gutjnl-2015-310230. doi: 10.1136/gutjnl-2015-310230. [Epub ahead of print]
PMID: 26565000 Free Article
Defects in 15-HETE Production and Control of Epithelial Permeability by Human Enteric Glial Cells From Patients With Crohn's Disease.
Pochard C, Coquenlorge S, Jaulin J, Cenac N, Vergnolle N, Meurette G, Freyssinet M, Neunlist M, Rolli-Derkinderen M.
Gastroenterology. 2016 Jan;150(1):168-80. doi: 10.1053/j.gastro.2015.09.038. Epub 2015 Nov 11.
PMID: 26433161
TRPV1 sensitization mediates postinflammatory visceral pain following acute colitis.
Lapointe TK, Basso L, Iftinca MC, Flynn R, Chapman K, Dietrich G, Vergnolle N, Altier C.
Am J Physiol Gastrointest Liver Physiol. 2015 Jul 15;309(2):G87-99. doi: 10.1152/ajpgi.00421.2014. Epub 2015 May 28.
PMID: 26021808 Free Article
Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome.
Cenac N, Bautzova T, Le Faouder P, Veldhuis NA, Poole DP, Rolland C, Bertrand J, Liedtke W, Dubourdeau M, Bertrand-Michel J, Zecchi L, Stanghellini V, Bunnett NW, Barbara G, Vergnolle N.
Gastroenterology. 2015 Aug;149(2):433-44.e7. doi: 10.1053/j.gastro.2015.04.011. Epub 2015 Apr 22.
PMID: 25911511
Serine protease inhibitors protect better than IL-10 and TGF-β anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci.
Bermúdez-Humarán LG, Motta JP, Aubry C, Kharrat P, Rous-Martin L, Sallenave JM, Deraison C, Vergnolle N, Langella P.
Microb Cell Fact. 2015 Feb 26;14:26. doi: 10.1186/s12934-015-0198-4.
PMID: 25889561 Free PMC Article
Novel role of the serine protease inhibitor elafin in gluten-related disorders.
Galipeau HJ, Wiepjes M, Motta JP, Schulz JD, Jury J, Natividad JM, Pinto-Sanchez I, Sinclair D, Rousset P, Martin-Rosique R, Bermudez-Humaran L, Leroux JC, Murray JA, Smecuol E, Bai JC, Vergnolle N, Langella P, Verdu EF.
Am J Gastroenterol. 2014 May;109(5):748-56. doi: 10.1038/ajg.2014.48. Epub 2014 Apr 8.
PMID: 24710505 Free PMC Article
Activated protein C based therapeutic strategies in chronic diseases.
Bock F, Shahzad K, Vergnolle N, Isermann B.
Thromb Haemost. 2014 Apr 1;111(4):610-7. doi: 10.1160/TH13-11-0967. Epub 2014 Mar 20. Review.
PMID: 24652581
TRPV4: new therapeutic target for inflammatory bowel diseases.
Vergnolle N.
Biochem Pharmacol. 2014 May 15;89(2):157-61. doi: 10.1016/j.bcp.2014.01.005. Epub 2014 Jan 16. Review.
PMID: 24440740
Polyunsaturated fatty acid metabolism signature in ischemia differs from reperfusion in mouse intestine.
Gobbetti T, Le Faouder P, Bertrand J, Dubourdeau M, Barocelli E, Cenac N, Vergnolle N.
PLoS One. 2013 Sep 20;8(9):e75581. doi: 10.1371/journal.pone.0075581. eCollection 2013.
PMID: 24073272 Free PMC Article
Endogenous regulation of visceral pain via production of opioids by colitogenic CD4(+) T cells in mice.
Boué J, Basso L, Cenac N, Blanpied C, Rolli-Derkinderen M, Neunlist M, Vergnolle N, Dietrich G.
Gastroenterology. 2014 Jan;146(1):166-75. doi: 10.1053/j.gastro.2013.09.020. Epub 2013 Sep 18.
PMID: 24055279
Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model.
Aerts L, Hamelin MÈ, Rhéaume C, Lavigne S, Couture C, Kim W, Susan-Resiga D, Prat A, Seidah NG, Vergnolle N, Riteau B, Boivin G.
PLoS One. 2013 Aug 28;8(8):e72529. doi: 10.1371/journal.pone.0072529. eCollection 2013.
PMID: 24015257 Free PMC Article
Engineering lactococci and lactobacilli for human health.
Bermúdez-Humarán LG, Aubry C, Motta JP, Deraison C, Steidler L, Vergnolle N, Chatel JM, Langella P.
Curr Opin Microbiol. 2013 Jun;16(3):278-83. doi: 10.1016/j.mib.2013.06.002. Epub 2013 Jul 11. Review.
PMID: 23850097
LC-MS/MS method for rapid and concomitant quantification of pro-inflammatory and pro-resolving polyunsaturated fatty acid metabolites.
Le Faouder P, Baillif V, Spreadbury I, Motta JP, Rousset P, Chêne G, Guigné C, Tercé F, Vanner S, Vergnolle N, Bertrand-Michel J, Dubourdeau M, Cenac N.
J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Aug 1;932:123-33. doi: 10.1016/j.jchromb.2013.06.014. Epub 2013 Jun 15.
PMID: 23831705
A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation.
Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S, Perretti M.
Blood. 2013 Jul 25;122(4):608-17. doi: 10.1182/blood-2013-04-496661. Epub 2013 Jun 3.
PMID: 23733341 Free PMC Article
Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update.
LeBlanc JG, Aubry C, Cortes-Perez NG, de Moreno de LeBlanc A, Vergnolle N, Langella P, Azevedo V, Chatel JM, Miyoshi A, Bermúdez-Humarán LG.
FEMS Microbiol Lett. 2013 Jul;344(1):1-9. doi: 10.1111/1574-6968.12159. Epub 2013 May 16. Review.
PMID: 23600579 Free Article
TRPM8 activation attenuates inflammatory responses in mouse models of colitis.
Ramachandran R, Hyun E, Zhao L, Lapointe TK, Chapman K, Hirota CL, Ghosh S, McKemy DD, Vergnolle N, Beck PL, Altier C, Hollenberg MD.
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7476-81. doi: 10.1073/pnas.1217431110. Epub 2013 Apr 17.
PMID: 23596210 Free PMC Article
Relevance of the cyclophosphamide-induced cystitis model for pharmacological studies targeting inflammation and pain of the bladder.
Augé C, Chene G, Dubourdeau M, Desoubzdanne D, Corman B, Palea S, Lluel P, Vergnolle N, Coelho AM.
Eur J Pharmacol. 2013 May 5;707(1-3):32-40. doi: 10.1016/j.ejphar.2013.03.008. Epub 2013 Mar 26.
PMID: 23541724
New neostigmine-based behavioral mouse model of abdominal pain.
Fichna J, Lapointe T, Chapman K, Janecka A, Vergnolle N, Altier C, Storr MA.
Pharmacol Rep. 2012;64(5):1146-54.
PMID: 23238471 Free Article
Food-grade bacteria expressing elafin protect against inflammation and restore colon homeostasis.
Motta JP, Bermúdez-Humarán LG, Deraison C, Martin L, Rolland C, Rousset P, Boue J, Dietrich G, Chapman K, Kharrat P, Vinel JP, Alric L, Mas E, Sallenave JM, Langella P, Vergnolle N.
Sci Transl Med. 2012 Oct 31;4(158):158ra144. doi: 10.1126/scitranslmed.3004212.
PMID: 23115353 Free Article
Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling.
Despeaux M, Chicanne G, Rouer E, De Toni-Costes F, Bertrand J, Mansat-De Mas V, Vergnolle N, Eaves C, Payrastre B, Girault JA, Racaud-Sultan C.
Stem Cells. 2012 Aug;30(8):1597-610. doi: 10.1002/stem.1157.
PMID: 22714993 Free Article
A spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease.
Chabod M, Pedros C, Lamouroux L, Colacios C, Bernard I, Lagrange D, Balz-Hara D, Mosnier JF, Laboisse C, Vergnolle N, Andreoletti O, Roth MP, Liblau R, Fournié GJ, Saoudi A, Dejean AS.
PLoS Genet. 2012 Jan;8(1):e1002461. doi: 10.1371/journal.pgen.1002461. Epub 2012 Jan 19.
PMID: 22275874 Free PMC Article
Immune conditions associated with CD4+ T effector-induced opioid release and analgesia.
Boué J, Blanpied C, Djata-Cabral M, Pelletier L, Vergnolle N, Dietrich G.
Pain. 2012 Feb;153(2):485-93. doi: 10.1016/j.pain.2011.11.013. Epub 2011 Dec 19.
PMID: 22188867
Role of transient receptor potential vanilloid 4 in rat joint inflammation.
Denadai-Souza A, Martin L, de Paula MA, de Avellar MC, Muscará MN, Vergnolle N, Cenac N.
Arthritis Rheum. 2012 Jun;64(6):1848-58. doi: 10.1002/art.34345. Epub 2011 Dec 19.
PMID: 22184014 Free Article
Serine protease inhibition reduces post-ischemic granulocyte recruitment in mouse intestine.
Gobbetti T, Cenac N, Motta JP, Rolland C, Martin L, Andrade-Gordon P, Steinhoff M, Barocelli E, Vergnolle N. Am J Pathol. 2012 Jan;180(1):141-52. doi: 10.1016/j.ajpath.2011.09.031. Epub 2011 Nov 7.
PMID: 22067907
Mechanisms behind the anti-inflammatory actions of insulin.
Hyun E, Ramachandran R, Hollenberg MD, Vergnolle N.
Crit Rev Immunol. 2011;31(4):307-40. Review.
PMID: 21899513
Brain-gut interactions increase peripheral nociceptive signaling in mice with postinfectious irritable bowel syndrome.
Ibeakanma C, Ochoa-Cortes F, Miranda-Morales M, McDonald T, Spreadbury I, Cenac N, Cattaruzza F, Hurlbut D, Vanner S, Bunnett N, Vergnolle N, Vanner S.
Gastroenterology. 2011 Dec;141(6):2098-2108.e5. doi: 10.1053/j.gastro.2011.08.006. Epub 2011 Aug 19.
PMID: 21856270
Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferon-γ on human neutrophils and monocytes.
Shpacovitch VM, Feld M, Holzinger D, Kido M, Hollenberg MD, Levi-Schaffer F, Vergnolle N, Ludwig S, Roth J, Luger T, Steinhoff M.
Immunology. 2011 Jul;133(3):329-39. doi: 10.1111/j.1365-2567.2011.03443.x. Epub 2011 Apr 19.
PMID: 21501162 Free PMC Article
Endogenous opioid-mediated analgesia is dependent on adaptive T cell response in mice.
Boué J, Blanpied C, Brousset P, Vergnolle N, Dietrich G.
J Immunol. 2011 May 1;186(9):5078-84. doi: 10.4049/jimmunol.1003335. Epub 2011 Mar 21.
PMID: 21422247 Free Article
Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.
Motta JP, Magne L, Descamps D, Rolland C, Squarzoni-Dale C, Rousset P, Martin L, Cenac N, Balloy V, Huerre M, Fröhlich LF, Jenne D, Wartelle J, Belaaouaj A, Mas E, Vinel JP, Alric L, Chignard M, Vergnolle N, Sallenave JM.
Gastroenterology. 2011 Apr;140(4):1272-82. doi: 10.1053/j.gastro.2010.12.050. Epub 2011 Jan 1.
PMID: 21199654
Transient receptor potential vanilloid 4 activated inflammatory signals by intestinal epithelial cells and colitis in mice.
D'Aldebert E, Cenac N, Rousset P, Martin L, Rolland C, Chapman K, Selves J, Alric L, Vinel JP, Vergnolle N.
Gastroenterology. 2011 Jan;140(1):275-85. doi: 10.1053/j.gastro.2010.09.045. Epub 2010 Oct 1.
PMID: 20888819
Contribution of bone marrow-derived cells to the pro-inflammatory effects of protease-activated receptor-2 in colitis.
Hyun E, Andrade-Gordon P, Steinhoff M, Beck PL, Vergnolle N.
Inflamm Res. 2010 Sep;59(9):699-709. doi: 10.1007/s00011-010-0181-9. Epub 2010 Mar 26.
PMID: 20339899 Free PMC Article
Potentiation of TRPV4 signalling by histamine and serotonin: an important mechanism for visceral hypersensitivity.
Cenac N, Altier C, Motta JP, d'Aldebert E, Galeano S, Zamponi GW, Vergnolle N.
Gut. 2010 Apr;59(4):481-8. doi: 10.1136/gut.2009.192567.
PMID: 20332520
Insulin modulates protease-activated receptor 2 signaling: implications for the innate immune response.
Hyun E, Ramachandran R, Cenac N, Houle S, Rousset P, Saxena A, Liblau RS, Hollenberg MD, Vergnolle N.
J Immunol. 2010 Mar 1;184(5):2702-9. doi: 10.4049/jimmunol.0902171. Epub 2010 Jan 29.
PMID: 20118282 Free Article
Thrombin receptor: An endogenous inhibitor of inflammatory pain, activating opioid pathways.
Martin L, Augé C, Boué J, Buresi MC, Chapman K, Asfaha S, Andrade-Gordon P, Steinhoff M, Cenac N, Dietrich G, Vergnolle N.
Pain. 2009 Nov;146(1-2):121-9. doi: 10.1016/j.pain.2009.07.016. Epub 2009 Aug 11.
PMID: 19674841
Visceral afferents: what role in post-inflammatory pain?
Vergnolle N.
Auton Neurosci. 2010 Feb 16;153(1-2):79-83. doi: 10.1016/j.autneu.2009.07.015. Epub 2009 Aug 9. Review.
PMID: 19666242
Analgesic properties of S100A9 C-terminal domain: a mechanism dependent on calcium channel inhibition.
Dale CS, Altier C, Cenac N, Giorgi R, Juliano MA, Juliano L, Zamponi GW, Vergnolle N.
Fundam Clin Pharmacol. 2009 Aug;23(4):427-38. doi: 10.1111/j.1472-8206.2009.00686.x. Epub 2009 Jun 8.
PMID: 19515068
Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway.
Khoufache K, LeBouder F, Morello E, Laurent F, Riffault S, Andrade-Gordon P, Boullier S, Rousset P, Vergnolle N, Riteau B.
J Immunol. 2009 Jun 15;182(12):7795-802. doi: 10.4049/jimmunol.0803743.
PMID: 19494303 Free Article
Protease-activated receptors as drug targets in inflammation and pain.
Vergnolle N.
Pharmacol Ther. 2009 Sep;123(3):292-309. doi: 10.1016/j.pharmthera.2009.05.004. Epub 2009 May 28. Review.
PMID: 19481569
Triggering of proteinase-activated receptor 4 leads to joint pain and inflammation in mice.
McDougall JJ, Zhang C, Cellars L, Joubert E, Dixon CM, Vergnolle N.
Arthritis Rheum. 2009 Mar;60(3):728-37. doi: 10.1002/art.24300.
PMID: 19248120 Free Article
Development, plasticity and modulation of visceral afferents.
Christianson JA, Bielefeldt K, Altier C, Cenac N, Davis BM, Gebhart GF, High KW, Kollarik M, Randich A, Undem B, Vergnolle N.
Brain Res Rev. 2009 Apr;60(1):171-86. doi: 10.1016/j.brainresrev.2008.12.004. Epub 2008 Dec 25. Review.
PMID: 19150371 Free PMC Article
Neutrophil-mediated activation of epithelial protease-activated receptors-1 and -2 regulates barrier function and transepithelial migration.
Chin AC, Lee WY, Nusrat A, Vergnolle N, Parkos CA.
J Immunol. 2008 Oct 15;181(8):5702-10.
PMID: 18832729 Free PMC Article
Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms.
Cenac N, Altier C, Chapman K, Liedtke W, Zamponi G, Vergnolle N.
Gastroenterology. 2008 Sep;135(3):937-46, 946.e1-2. doi: 10.1053/j.gastro.2008.05.024. Epub 2008 May 10.
PMID: 18565335
Derivatized 2-furoyl-LIGRLO-amide, a versatile and selective probe for proteinase-activated receptor 2: binding and visualization.
Hollenberg MD, Renaux B, Hyun E, Houle S, Vergnolle N, Saifeddine M, Ramachandran R.
J Pharmacol Exp Ther. 2008 Aug;326(2):453-62. doi: 10.1124/jpet.108.136432. Epub 2008 May 13.
PMID: 18477767 Free Article
Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection.
Feld M, Shpacovitch VM, Ehrhardt C, Kerkhoff C, Hollenberg MD, Vergnolle N, Ludwig S, Steinhoff M.
J Immunol. 2008 May 15;180(10):6903-10.
PMID: 18453611 Free Article
Protease signaling to G protein-coupled receptors: implications for inflammation and pain.
Dale C, Vergnolle N.
J Recept Signal Transduct Res. 2008;28(1-2):29-37. doi: 10.1080/10799890801941913 . Review.
PMID: 18437628
Proteinase-activated receptors (PARs) in infection and inflammation in the gut.
Vergnolle N.
Int J Biochem Cell Biol. 2008;40(6-7):1219-27. doi: 10.1016/j.biocel.2008.01.016. Epub 2008 Jan 20. Review.
PMID: 18313348
Mechanisms underlying the nociceptive and inflammatory responses induced by trypsin in the mouse paw.
Paszcuk AF, Quintão NL, Fernandes ES, Juliano L, Chapman K, Andrade-Gordon P, Campos MM, Vergnolle N, Calixto JB.
Eur J Pharmacol. 2008 Feb 26;581(1-2):204-15. Epub 2007 Nov 23.
PMID: 18083162
Intrathecal administration of proteinase-activated receptor-2 agonists produces hyperalgesia by exciting the cell bodies of primary sensory neurons.
Alier KA, Endicott JA, Stemkowski PL, Cenac N, Cellars L, Chapman K, Andrade-Gordon P, Vergnolle N, Smith PA.
J Pharmacol Exp Ther. 2008 Jan;324(1):224-33. Epub 2007 Oct 5.
PMID: 17921188 Free Article
Proteinase-activated receptor-2 exerts protective and pathogenic cell type-specific effects in Alzheimer's disease.
Afkhami-Goli A, Noorbakhsh F, Keller AJ, Vergnolle N, Westaway D, Jhamandas JH, Andrade-Gordon P, Hollenberg MD, Arab H, Dyck RH, Power C.
J Immunol. 2007 Oct 15;179(8):5493-503.
PMID: 17911636 Free Article
Agonists of proteinase-activated receptor-2 affect transendothelial migration and apoptosis of human neutrophils.
Shpacovitch VM, Seeliger S, Huber-Lang M, Balkow S, Feld M, Hollenberg MD, Sarma VJ, Ward PA, Strey A, Gerke V, Sommerhoff CP, Vergnolle N, Steinhoff M.
Exp Dermatol. 2007 Oct;16(10):799-806.
PMID: 17845211
Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia.
Knecht W, Cottrell GS, Amadesi S, Mohlin J, Skåregärde A, Gedda K, Peterson A, Chapman K, Hollenberg MD, Vergnolle N, Bunnett NW.
J Biol Chem. 2007 Sep 7;282(36):26089-100. Epub 2007 Jul 10.
PMID: 17623652 Free Article
Differential role of N-type calcium channel splice isoforms in pain.
Altier C, Dale CS, Kisilevsky AE, Chapman K, Castiglioni AJ, Matthews EA, Evans RM, Dickenson AH, Lipscombe D, Vergnolle N, Zamponi GW.
J Neurosci. 2007 Jun 13;27(24):6363-73.
PMID: 17567797 Free Article
Citrobacter rodentium infection causes iNOS-independent intestinal epithelial dysfunction in mice.
Skinn AC, Vergnolle N, Zamuner SR, Wallace JL, Cellars L, MacNaughton WK, Sherman PM.
Can J Physiol Pharmacol. 2006 Dec;84(12):1301-12.
PMID: 17487239
Proteinase-activated receptor-2 (PAR2): a tumor suppressor in skin carcinogenesis.
Rattenholl A, Seeliger S, Buddenkotte J, Schön M, Schön MP, Ständer S, Vergnolle N, Steinhoff M.
J Invest Dermatol. 2007 Sep;127(9):2245-52. Epub 2007 May 3.
PMID: 17476297 Free Article
Role for protease activity in visceral pain in irritable bowel syndrome.
Cenac N, Andrews CN, Holzhausen M, Chapman K, Cottrell G, Andrade-Gordon P, Steinhoff M, Barbara G, Beck P, Bunnett NW, Sharkey KA, Ferraz JG, Shaffer E, Vergnolle N.
J Clin Invest. 2007 Mar;117(3):636-47. Epub 2007 Feb 15.
PMID: 17304351 Free PMC Article
Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice.
Grant AD, Cottrell GS, Amadesi S, Trevisani M, Nicoletti P, Materazzi S, Altier C, Cenac N, Zamponi GW, Bautista-Cruz F, Lopez CB, Joseph EK, Levine JD, Liedtke W, Vanner S, Vergnolle N, Geppetti P, Bunnett NW.
J Physiol. 2007 Feb 1;578(Pt 3):715-33. Epub 2006 Nov 23.
PMID: 17124270 Free PMC Article
A role for proteinase-activated receptor-1 in inflammatory bowel diseases.
Vergnolle N, Cellars L, Mencarelli A, Rizzo G, Swaminathan S, Beck P, Steinhoff M, Andrade-Gordon P, Bunnett NW, Hollenberg MD, Wallace JL, Cirino G, Fiorucci S.
J Clin Invest. 2006 Jul;116(7):2056. No abstract available.
PMID: 16881139 Free PMC Article
Protective effect of proteinase-activated receptor 2 activation on motility impairment and tissue damage induced by intestinal ischemia/reperfusion in rodents.
Cattaruzza F, Cenac N, Barocelli E, Impicciatore M, Hyun E, Vergnolle N, Sternini C.
Am J Pathol. 2006 Jul;169(1):177-88.
PMID: 16816371 Free PMC Article
Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs).
Oikonomopoulou K, Hansen KK, Saifeddine M, Vergnolle N, Tea I, Blaber M, Blaber SI, Scarisbrick I, Diamandis EP, Hollenberg MD.
Biol Chem. 2006 Jun;387(6):817-24.
PMID: 16800746
Proteinase-mediated cell signalling: targeting proteinase-activated receptors (PARs) by kallikreins and more.
Oikonomopoulou K, Hansen KK, Saifeddine M, Vergnolle N, Tea I, Diamandis EP, Hollenberg MD.
Biol Chem. 2006 Jun;387(6):677-85. Review.
PMID: 16800728
Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice.
Amadesi S, Cottrell GS, Divino L, Chapman K, Grady EF, Bautista F, Karanjia R, Barajas-Lopez C, Vanner S, Vergnolle N, Bunnett NW.
J Physiol. 2006 Sep 1;575(Pt 2):555-71. Epub 2006 Jun 22.
PMID: 16793902 Free PMC Article
Proteinase-activated receptors (PARs): crossroads between innate immunity and coagulation.
Cirino G, Vergnolle N.
Curr Opin Pharmacol. 2006 Aug;6(4):428-34. Epub 2006 Jun 13. Review.
PMID: 16777485
Protease-activated receptor-2 activation: a major role in the pathogenesis of Porphyromonas gingivalis infection.
Holzhausen M, Spolidorio LC, Ellen RP, Jobin MC, Steinhoff M, Andrade-Gordon P, Vergnolle N.
Am J Pathol. 2006 Apr;168(4):1189-99.
PMID: 16565494 Free PMC Article
Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis.
Noorbakhsh F, Tsutsui S, Vergnolle N, Boven LA, Shariat N, Vodjgani M, Warren KG, Andrade-Gordon P, Hollenberg MD, Power C.
J Exp Med. 2006 Feb 20;203(2):425-35. Epub 2006 Feb 13.
PMID: 16476770 Free PMC Article
Functional characterization and expression analysis of the proteinase-activated receptor-2 in human cutaneous mast cells.
Moormann C, Artuc M, Pohl E, Varga G, Buddenkotte J, Vergnolle N, Brehler R, Henz BM, Schneider SW, Luger TA, Steinhoff M.
J Invest Dermatol. 2006 Apr;126(4):746-55.
PMID: 16470180 Free Article
Endogenous opioid-mediated antinociception in cholestatic mice is peripherally, not centrally, mediated.
Nelson L, Vergnolle N, D'Mello C, Chapman K, Le T, Swain MG.
J Hepatol. 2006 Jun;44(6):1141-9. Epub 2005 Dec 27.
PMID: 16466825
Neonatal immune challenge alters nociception in the adult rat.
Boissé L, Spencer SJ, Mouihate A, Vergnolle N, Pittman QJ.
Pain. 2005 Dec 15;119(1-3):133-41. Epub 2005 Nov 16.
PMID: 16297551
Proteinase-activated receptor-1 is an anti-inflammatory signal for colitis mediated by a type 2 immune response.
Cenac N, Cellars L, Steinhoff M, Andrade-Gordon P, Hollenberg MD, Wallace JL, Fiorucci S, Vergnolle N.
Inflamm Bowel Dis. 2005 Sep;11(9):792-8.
PMID: 16116312
Neutrophils and the kallikrein-kinin system in proteinase-activated receptor 4-mediated inflammation in rodents.
Houle S, Papez MD, Ferazzini M, Hollenberg MD, Vergnolle N.
Br J Pharmacol. 2005 Nov;146(5):670-8.
PMID: 16100525 Free PMC Article
Protease-activated receptors and inflammatory hyperalgesia.
Vergnolle N.
Mem Inst Oswaldo Cruz. 2005 Mar;100 Suppl 1:173-6. Epub 2005 Jun 14. Review.
PMID: 15962118 Free Article
A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis.
Hansen KK, Sherman PM, Cellars L, Andrade-Gordon P, Pan Z, Baruch A, Wallace JL, Hollenberg MD, Vergnolle N.
Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8363-8. Epub 2005 May 26.
PMID: 15919826 Free PMC Article
Proteinase-activated receptor-2 induction by neuroinflammation prevents neuronal death during HIV infection.
Noorbakhsh F, Vergnolle N, McArthur JC, Silva C, Vodjgani M, Andrade-Gordon P, Hollenberg MD, Power C.
J Immunol. 2005 Jun 1;174(11):7320-9.
PMID: 15905579 Free Article
Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis.
Chou MM, Vergnolle N, McDougall JJ, Wallace JL, Marty S, Teskey V, Buret AG.
Exp Biol Med (Maywood). 2005 Apr;230(4):255-62.
PMID: 15792947
Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response.
Steinhoff M, Buddenkotte J, Shpacovitch V, Rattenholl A, Moormann C, Vergnolle N, Luger TA, Hollenberg MD.
Endocr Rev. 2005 Feb;26(1):1-43. Review.
PMID: 15689571
Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B.
Buddenkotte J, Stroh C, Engels IH, Moormann C, Shpacovitch VM, Seeliger S, Vergnolle N, Vestweber D, Luger TA, Schulze-Osthoff K, Steinhoff M.
J Invest Dermatol. 2005 Jan;124(1):38-45.
PMID: 15654951 Free Article
A role for proteinase-activated receptor-1 in inflammatory bowel diseases.
Vergnolle N, Cellars L, Mencarelli A, Rizzo G, Swaminathan S, Beck P, Steinhoff M, Andrade-Gordon P, Bunnett NW, Hollenberg MD, Wallace JL, Cirino G, Fiorucci S.
J Clin Invest. 2004 Nov;114(10):1444-56. Retraction in: Vergnolle N, Cellars L, Mencarelli A, Rizzo G, Swaminathan S, Beck P, Steinhoff M, Andrade-Gordon P, Bunnett NW, Hollenberg MD, Wallace JL, Cirino G, Fiorucci S. J Clin Invest. 2006 Jul;116(7):2056.
PMID: 15545995 Free PMC Article
Annexin 1 is secreted in situ during ulcerative colitis in humans.
Vergnolle N, Pagès P, Guimbaud R, Chaussade S, Buéno L, Escourrou J, Coméra C.
Inflamm Bowel Dis. 2004 Sep;10(5):584-92.
PMID: 15472519
Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo.
Hollenberg MD, Saifeddine M, Sandhu S, Houle S, Vergnolle N.
Br J Pharmacol. 2004 Oct;143(4):443-54. Epub 2004 Sep 27.
PMID: 15451771 Free PMC Article
Activation of proteinase-activated receptor-1 inhibits neurally evoked chloride secretion in the mouse colon in vitro.
Buresi MC, Vergnolle N, Sharkey KA, Keenan CM, Andrade-Gordon P, Cirino G, Cirillo D, Hollenberg MD, MacNaughton WK.
Am J Physiol Gastrointest Liver Physiol. 2005 Feb;288(2):G337-45. Epub 2004 Sep 2.
PMID: 15345469 Free Article
Proteinase-activated receptor 2 activation modulates guinea-pig mesenteric lymphatic vessel pacemaker potential and contractile activity.
Chan AK, Vergnolle N, Hollenberg MD, von der Weid PY.
J Physiol. 2004 Oct 15;560(Pt 2):563-76. Epub 2004 Aug 26.
PMID: 15331674 Free PMC Article
Anti-inflammatory effects of nitric oxide-releasing hydrocortisone NCX 1022, in a murine model of contact dermatitis.
Hyun E, Bolla M, Steinhoff M, Wallace JL, Soldato PD, Vergnolle N.
Br J Pharmacol. 2004 Nov;143(5):618-25. Epub 2004 Aug 16.
PMID: 15313880 Free PMC Article
PAR2 activation alters colonic paracellular permeability in mice via IFN-gamma-dependent and -independent pathways.
Cenac N, Chin AC, Garcia-Villar R, Salvador-Cartier C, Ferrier L, Vergnolle N, Buret AG, Fioramonti J, Bueno L.
J Physiol. 2004 Aug 1;558(Pt 3):913-25. Epub 2004 Jun 11.
PMID: 15194744 Free PMC Article
Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.
Amadesi S, Nie J, Vergnolle N, Cottrell GS, Grady EF, Trevisani M, Manni C, Geppetti P, McRoberts JA, Ennes H, Davis JB, Mayer EA, Bunnett NW.
J Neurosci. 2004 May 5;24(18):4300-12.
PMID: 15128844 Free Article
Modulation of visceral pain and inflammation by protease-activated receptors.
Vergnolle N.
Br J Pharmacol. 2004 Apr;141(8):1264-74. Epub 2004 Mar 29. Review.
PMID: 15051630 Free PMC Article
Proteinase-activated receptors in the nervous system.
Noorbakhsh F, Vergnolle N, Hollenberg MD, Power C.
Nat Rev Neurosci. 2003 Dec;4(12):981-90. Review.
PMID: 14682360
Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism.
Nguyen C, Coelho AM, Grady E, Compton SJ, Wallace JL, Hollenberg MD, Cenac N, Garcia-Villar R, Bueno L, Steinhoff M, Bunnett NW, Vergnolle N.
Can J Physiol Pharmacol. 2003 Sep;81(9):920-7.
PMID: 14614531
The enteric nervous system in inflammation and pain: the role of proteinase-activated receptors.
Vergnolle N.
Can J Gastroenterol. 2003 Oct;17(10):589-92. Review.
Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo.
Seeliger S, Derian CK, Vergnolle N, Bunnett NW, Nawroth R, Schmelz M, Von Der Weid PY, Buddenkotte J, Sunderkötter C, Metze D, Andrade-Gordon P, Harms E, Vestweber D, Luger TA, Steinhoff M.
FASEB J. 2003 Oct;17(13):1871-85.
PMID: 14519665 Free Article
Proteinase-activated receptor 1 activation induces epithelial apoptosis and increases intestinal permeability.
Chin AC, Vergnolle N, MacNaughton WK, Wallace JL, Hollenberg MD, Buret AG.
Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11104-9. Epub 2003 Sep 5.
PMID: 12960392 Free PMC Article
Proteinase-activated receptors: novel signals for peripheral nerves.
Vergnolle N, Ferazzini M, D'Andrea MR, Buddenkotte J, Steinhoff M.
Trends Neurosci. 2003 Sep;26(9):496-500. Review.
PMID: 12948661
Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability.
Cenac N, Garcia-Villar R, Ferrier L, Larauche M, Vergnolle N, Bunnett NW, Coelho AM, Fioramonti J, Bueno L.
J Immunol. 2003 Apr 15;170(8):4296-300.
PMID: 12682265 Free Article
Up-regulation of proteinase-activated receptor 1 expression in astrocytes during HIV encephalitis.
Boven LA, Vergnolle N, Henry SD, Silva C, Imai Y, Holden J, Warren K, Hollenberg MD, Power C.
J Immunol. 2003 Mar 1;170(5):2638-46.
PMID: 12594292 Free Article
Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2.
Cenac N, Coelho AM, Nguyen C, Compton S, Andrade-Gordon P, MacNaughton WK, Wallace JL, Hollenberg MD, Bunnett NW, Garcia-Villar R, Bueno L, Vergnolle N.
Am J Pathol. 2002 Nov;161(5):1903-15.
PMID: 12414536 Free PMC Article
Characterization of thrombin-induced leukocyte rolling and adherence: a potential proinflammatory role for proteinase-activated receptor-4.
Vergnolle N, Derian CK, D'Andrea MR, Steinhoff M, Andrade-Gordon P.
J Immunol. 2002 Aug 1;169(3):1467-73.
PMID: 12133973 Free Article
Proteinases and proteinase-activated receptor 2: a possible role to promote visceral hyperalgesia in rats.
Coelho AM, Vergnolle N, Guiard B, Fioramonti J, Bueno L.
Gastroenterology. 2002 Apr;122(4):1035-47.
PMID: 11910355
Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli.
Asfaha S, Brussee V, Chapman K, Zochodne DW, Vergnolle N.
Br J Pharmacol. 2002 Mar;135(5):1101-6.
PMID: 11877315 Free PMC Article
PAR2-dependent activation of GSK3β regulates the survival of colon stem/progenitor cells.
Nasri I, Bonnet D, Zwarycz B, D'Aldebert E, Khou S, Mezghani-Jarraya R, Quaranta M, Rolland C, Bonnart C, Mas E, Ferrand A, Cenac N, Magness S, Van Landeghem L, Vergnolle N, Racaud-Sultan C.
Am J Physiol Gastrointest Liver Physiol. 2016 Jun 16:ajpgi.00328.2015. doi: 10.1152/ajpgi.00328.2015. [Epub ahead of print]
PMID: 27313176
Endogenous analgesia mediated by CD4(+) T lymphocytes is dependent on enkephalins in mice.
Basso L, Boué J, Mahiddine K, Blanpied C, Robiou-du-Pont S, Vergnolle N, Deraison C, Dietrich G.
J Neuroinflammation. 2016 Jun 1;13(1):132. doi: 10.1186/s12974-016-0591-x.
PMID: 27245576 Free PMC Article
Protease inhibition as new therapeutic strategy for GI diseases.
Vergnolle N.
Gut. 2016 Jul;65(7):1215-24. doi: 10.1136/gutjnl-2015-309147. Epub 2016 Apr 12. Review.
PMID: 27196587 Free PMC Article
The Intestinal Microenvironment and Functional Gastrointestinal Disorders.
Barbara G, Feinle-Bisset C, Ghoshal UC, Quigley EM, Santos J, Vanner S, Vergnolle N, Zoetendal EG.
Gastroenterology. 2016 Feb 18. pii: S0016-5085(16)00219-5. doi: 10.1053/j.gastro.2016.02.028. [Epub ahead of print]
PMID: 27144620
The arachidonic acid metabolite 11β-ProstaglandinF2α controls intestinal epithelial healing: deficiency in patients with Crohn's disease.
Coquenlorge S, Van Landeghem L, Jaulin J, Cenac N, Vergnolle N, Duchalais E, Neunlist M, Rolli-Derkinderen M.
Sci Rep. 2016 May 3;6:25203. doi: 10.1038/srep25203.
PMID: 27140063 Free PMC Article
Formyl Peptide Receptor 2 Plays a Deleterious Role During Influenza A Virus Infections.
Tcherniuk S, Cenac N, Comte M, Frouard J, Errazuriz-Cerda E, Galabov A, Morange PE, Vergnolle N, Si-Tahar M, Alessi MC, Riteau B.
J Infect Dis. 2016 Jul 15;214(2):237-47. doi: 10.1093/infdis/jiw127. Epub 2016 Mar 30.
PMID: 27034344
Sacral nerve stimulation enhances early intestinal mucosal repair following mucosal injury in a pig model.
Brégeon J, Coron E, Da Silva AC, Jaulin J, Aubert P, Chevalier J, Vergnolle N, Meurette G, Neunlist M.
J Physiol. 2016 Mar 4. doi: 10.1113/JP271783. [Epub ahead of print]
PMID: 26939757
Bladder telemetry: A new approach to evaluate micturition behavior under physiological and inflammatory conditions.
Monjotin N, Farrié M, Vergnolle N, Le Grand B, Gillespie J, Junquero D.
Neurourol Urodyn. 2016 Feb 16. doi: 10.1002/nau.22970. [Epub ahead of print]
PMID: 26879122
Reply.
Vergnolle N.
Gastroenterology. 2016 Mar;150(3):777-8. doi: 10.1053/j.gastro.2016.01.026. Epub 2016 Jan 29. No abstract available.
PMID: 26827802
Presence of commensal house dust mite allergen in human gastrointestinal tract: a potential contributor to intestinal barrier dysfunction.
Tulic MK, Vivinus-Nébot M, Rekima A, Rabelo Medeiros S, Bonnart C, Shi H, Walker A, Dainese R, Boyer J, Vergnolle N, Piche T, Verhasselt V.
Gut. 2016 May;65(5):757-66. doi: 10.1136/gutjnl-2015-310523. Epub 2015 Dec 8.
PMID: 26646935
Apelin targets gut contraction to control glucose metabolism via the brain.
Fournel A, Drougard A, Duparc T, Marlin A, Brierley SM, Castro J, Le-Gonidec S, Masri B, Colom A, Lucas A, Rousset P, Cenac N, Vergnolle N, Valet P, Cani PD, Knauf C.
Gut. 2015 Nov 12. pii: gutjnl-2015-310230. doi: 10.1136/gutjnl-2015-310230. [Epub ahead of print]
PMID: 26565000 Free Article
Defects in 15-HETE Production and Control of Epithelial Permeability by Human Enteric Glial Cells From Patients With Crohn's Disease.
Pochard C, Coquenlorge S, Jaulin J, Cenac N, Vergnolle N, Meurette G, Freyssinet M, Neunlist M, Rolli-Derkinderen M.
Gastroenterology. 2016 Jan;150(1):168-80. doi: 10.1053/j.gastro.2015.09.038. Epub 2015 Nov 11.
PMID: 26433161
TRPV1 sensitization mediates postinflammatory visceral pain following acute colitis.
Lapointe TK, Basso L, Iftinca MC, Flynn R, Chapman K, Dietrich G, Vergnolle N, Altier C.
Am J Physiol Gastrointest Liver Physiol. 2015 Jul 15;309(2):G87-99. doi: 10.1152/ajpgi.00421.2014. Epub 2015 May 28.
PMID: 26021808 Free Article
Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome.
Cenac N, Bautzova T, Le Faouder P, Veldhuis NA, Poole DP, Rolland C, Bertrand J, Liedtke W, Dubourdeau M, Bertrand-Michel J, Zecchi L, Stanghellini V, Bunnett NW, Barbara G, Vergnolle N.
Gastroenterology. 2015 Aug;149(2):433-44.e7. doi: 10.1053/j.gastro.2015.04.011. Epub 2015 Apr 22.
PMID: 25911511
Serine protease inhibitors protect better than IL-10 and TGF-β anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci.
Bermúdez-Humarán LG, Motta JP, Aubry C, Kharrat P, Rous-Martin L, Sallenave JM, Deraison C, Vergnolle N, Langella P.
Microb Cell Fact. 2015 Feb 26;14:26. doi: 10.1186/s12934-015-0198-4.
PMID: 25889561 Free PMC Article
Novel role of the serine protease inhibitor elafin in gluten-related disorders.
Galipeau HJ, Wiepjes M, Motta JP, Schulz JD, Jury J, Natividad JM, Pinto-Sanchez I, Sinclair D, Rousset P, Martin-Rosique R, Bermudez-Humaran L, Leroux JC, Murray JA, Smecuol E, Bai JC, Vergnolle N, Langella P, Verdu EF.
Am J Gastroenterol. 2014 May;109(5):748-56. doi: 10.1038/ajg.2014.48. Epub 2014 Apr 8.
PMID: 24710505 Free PMC Article
Activated protein C based therapeutic strategies in chronic diseases.
Bock F, Shahzad K, Vergnolle N, Isermann B.
Thromb Haemost. 2014 Apr 1;111(4):610-7. doi: 10.1160/TH13-11-0967. Epub 2014 Mar 20. Review.
PMID: 24652581
TRPV4: new therapeutic target for inflammatory bowel diseases.
Vergnolle N.
Biochem Pharmacol. 2014 May 15;89(2):157-61. doi: 10.1016/j.bcp.2014.01.005. Epub 2014 Jan 16. Review.
PMID: 24440740
Polyunsaturated fatty acid metabolism signature in ischemia differs from reperfusion in mouse intestine.
Gobbetti T, Le Faouder P, Bertrand J, Dubourdeau M, Barocelli E, Cenac N, Vergnolle N.
PLoS One. 2013 Sep 20;8(9):e75581. doi: 10.1371/journal.pone.0075581. eCollection 2013.
PMID: 24073272 Free PMC Article
Endogenous regulation of visceral pain via production of opioids by colitogenic CD4(+) T cells in mice.
Boué J, Basso L, Cenac N, Blanpied C, Rolli-Derkinderen M, Neunlist M, Vergnolle N, Dietrich G.
Gastroenterology. 2014 Jan;146(1):166-75. doi: 10.1053/j.gastro.2013.09.020. Epub 2013 Sep 18.
PMID: 24055279
Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model.
Aerts L, Hamelin MÈ, Rhéaume C, Lavigne S, Couture C, Kim W, Susan-Resiga D, Prat A, Seidah NG, Vergnolle N, Riteau B, Boivin G.
PLoS One. 2013 Aug 28;8(8):e72529. doi: 10.1371/journal.pone.0072529. eCollection 2013.
PMID: 24015257 Free PMC Article
Engineering lactococci and lactobacilli for human health.
Bermúdez-Humarán LG, Aubry C, Motta JP, Deraison C, Steidler L, Vergnolle N, Chatel JM, Langella P.
Curr Opin Microbiol. 2013 Jun;16(3):278-83. doi: 10.1016/j.mib.2013.06.002. Epub 2013 Jul 11. Review.
PMID: 23850097
LC-MS/MS method for rapid and concomitant quantification of pro-inflammatory and pro-resolving polyunsaturated fatty acid metabolites.
Le Faouder P, Baillif V, Spreadbury I, Motta JP, Rousset P, Chêne G, Guigné C, Tercé F, Vanner S, Vergnolle N, Bertrand-Michel J, Dubourdeau M, Cenac N.
J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Aug 1;932:123-33. doi: 10.1016/j.jchromb.2013.06.014. Epub 2013 Jun 15.
PMID: 23831705
A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation.
Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S, Perretti M.
Blood. 2013 Jul 25;122(4):608-17. doi: 10.1182/blood-2013-04-496661. Epub 2013 Jun 3.
PMID: 23733341 Free PMC Article
Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update.
LeBlanc JG, Aubry C, Cortes-Perez NG, de Moreno de LeBlanc A, Vergnolle N, Langella P, Azevedo V, Chatel JM, Miyoshi A, Bermúdez-Humarán LG.
FEMS Microbiol Lett. 2013 Jul;344(1):1-9. doi: 10.1111/1574-6968.12159. Epub 2013 May 16. Review.
PMID: 23600579 Free Article
TRPM8 activation attenuates inflammatory responses in mouse models of colitis.
Ramachandran R, Hyun E, Zhao L, Lapointe TK, Chapman K, Hirota CL, Ghosh S, McKemy DD, Vergnolle N, Beck PL, Altier C, Hollenberg MD.
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7476-81. doi: 10.1073/pnas.1217431110. Epub 2013 Apr 17.
PMID: 23596210 Free PMC Article
Relevance of the cyclophosphamide-induced cystitis model for pharmacological studies targeting inflammation and pain of the bladder.
Augé C, Chene G, Dubourdeau M, Desoubzdanne D, Corman B, Palea S, Lluel P, Vergnolle N, Coelho AM.
Eur J Pharmacol. 2013 May 5;707(1-3):32-40. doi: 10.1016/j.ejphar.2013.03.008. Epub 2013 Mar 26.
PMID: 23541724
New neostigmine-based behavioral mouse model of abdominal pain.
Fichna J, Lapointe T, Chapman K, Janecka A, Vergnolle N, Altier C, Storr MA.
Pharmacol Rep. 2012;64(5):1146-54.
PMID: 23238471 Free Article
Food-grade bacteria expressing elafin protect against inflammation and restore colon homeostasis.
Motta JP, Bermúdez-Humarán LG, Deraison C, Martin L, Rolland C, Rousset P, Boue J, Dietrich G, Chapman K, Kharrat P, Vinel JP, Alric L, Mas E, Sallenave JM, Langella P, Vergnolle N.
Sci Transl Med. 2012 Oct 31;4(158):158ra144. doi: 10.1126/scitranslmed.3004212.
PMID: 23115353 Free Article
Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling.
Despeaux M, Chicanne G, Rouer E, De Toni-Costes F, Bertrand J, Mansat-De Mas V, Vergnolle N, Eaves C, Payrastre B, Girault JA, Racaud-Sultan C.
Stem Cells. 2012 Aug;30(8):1597-610. doi: 10.1002/stem.1157.
PMID: 22714993 Free Article
A spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease.
Chabod M, Pedros C, Lamouroux L, Colacios C, Bernard I, Lagrange D, Balz-Hara D, Mosnier JF, Laboisse C, Vergnolle N, Andreoletti O, Roth MP, Liblau R, Fournié GJ, Saoudi A, Dejean AS.
PLoS Genet. 2012 Jan;8(1):e1002461. doi: 10.1371/journal.pgen.1002461. Epub 2012 Jan 19.
PMID: 22275874 Free PMC Article
Immune conditions associated with CD4+ T effector-induced opioid release and analgesia.
Boué J, Blanpied C, Djata-Cabral M, Pelletier L, Vergnolle N, Dietrich G.
Pain. 2012 Feb;153(2):485-93. doi: 10.1016/j.pain.2011.11.013. Epub 2011 Dec 19.
PMID: 22188867
Role of transient receptor potential vanilloid 4 in rat joint inflammation.
Denadai-Souza A, Martin L, de Paula MA, de Avellar MC, Muscará MN, Vergnolle N, Cenac N.
Arthritis Rheum. 2012 Jun;64(6):1848-58. doi: 10.1002/art.34345. Epub 2011 Dec 19.
PMID: 22184014 Free Article
Serine protease inhibition reduces post-ischemic granulocyte recruitment in mouse intestine.
Gobbetti T, Cenac N, Motta JP, Rolland C, Martin L, Andrade-Gordon P, Steinhoff M, Barocelli E, Vergnolle N.
Am J Pathol. 2012 Jan;180(1):141-52. doi: 10.1016/j.ajpath.2011.09.031. Epub 2011 Nov 7.
PMID: 22067907
Mechanisms behind the anti-inflammatory actions of insulin.
Hyun E, Ramachandran R, Hollenberg MD, Vergnolle N.
Crit Rev Immunol. 2011;31(4):307-40. Review.
PMID: 21899513
Brain-gut interactions increase peripheral nociceptive signaling in mice with postinfectious irritable bowel syndrome.
Ibeakanma C, Ochoa-Cortes F, Miranda-Morales M, McDonald T, Spreadbury I, Cenac N, Cattaruzza F, Hurlbut D, Vanner S, Bunnett N, Vergnolle N, Vanner S.
Gastroenterology. 2011 Dec;141(6):2098-2108.e5. doi: 10.1053/j.gastro.2011.08.006. Epub 2011 Aug 19.
PMID: 21856270
Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferon-γ on human neutrophils and monocytes.
Shpacovitch VM, Feld M, Holzinger D, Kido M, Hollenberg MD, Levi-Schaffer F, Vergnolle N, Ludwig S, Roth J, Luger T, Steinhoff M.
Immunology. 2011 Jul;133(3):329-39. doi: 10.1111/j.1365-2567.2011.03443.x. Epub 2011 Apr 19.
PMID: 21501162 Free PMC Article
Endogenous opioid-mediated analgesia is dependent on adaptive T cell response in mice.
Boué J, Blanpied C, Brousset P, Vergnolle N, Dietrich G.
J Immunol. 2011 May 1;186(9):5078-84. doi: 10.4049/jimmunol.1003335. Epub 2011 Mar 21.
PMID: 21422247 Free Article
Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.
Motta JP, Magne L, Descamps D, Rolland C, Squarzoni-Dale C, Rousset P, Martin L, Cenac N, Balloy V, Huerre M, Fröhlich LF, Jenne D, Wartelle J, Belaaouaj A, Mas E, Vinel JP, Alric L, Chignard M, Vergnolle N, Sallenave JM.
Gastroenterology. 2011 Apr;140(4):1272-82. doi: 10.1053/j.gastro.2010.12.050. Epub 2011 Jan 1.
PMID: 21199654
Transient receptor potential vanilloid 4 activated inflammatory signals by intestinal epithelial cells and colitis in mice.
D'Aldebert E, Cenac N, Rousset P, Martin L, Rolland C, Chapman K, Selves J, Alric L, Vinel JP, Vergnolle N.
Gastroenterology. 2011 Jan;140(1):275-85. doi: 10.1053/j.gastro.2010.09.045. Epub 2010 Oct 1.
PMID: 20888819
Contribution of bone marrow-derived cells to the pro-inflammatory effects of protease-activated receptor-2 in colitis.
Hyun E, Andrade-Gordon P, Steinhoff M, Beck PL, Vergnolle N.
Inflamm Res. 2010 Sep;59(9):699-709. doi: 10.1007/s00011-010-0181-9. Epub 2010 Mar 26.
PMID: 20339899 Free PMC Article
Potentiation of TRPV4 signalling by histamine and serotonin: an important mechanism for visceral hypersensitivity.
Cenac N, Altier C, Motta JP, d'Aldebert E, Galeano S, Zamponi GW, Vergnolle N.
Gut. 2010 Apr;59(4):481-8. doi: 10.1136/gut.2009.192567.
PMID: 20332520
Insulin modulates protease-activated receptor 2 signaling: implications for the innate immune response.
Hyun E, Ramachandran R, Cenac N, Houle S, Rousset P, Saxena A, Liblau RS, Hollenberg MD, Vergnolle N.
J Immunol. 2010 Mar 1;184(5):2702-9. doi: 10.4049/jimmunol.0902171. Epub 2010 Jan 29.
PMID: 20118282 Free Article
Thrombin receptor: An endogenous inhibitor of inflammatory pain, activating opioid pathways.
Martin L, Augé C, Boué J, Buresi MC, Chapman K, Asfaha S, Andrade-Gordon P, Steinhoff M, Cenac N, Dietrich G, Vergnolle N.
Pain. 2009 Nov;146(1-2):121-9. doi: 10.1016/j.pain.2009.07.016. Epub 2009 Aug 11.
PMID: 19674841
Visceral afferents: what role in post-inflammatory pain?
Vergnolle N.
Auton Neurosci. 2010 Feb 16;153(1-2):79-83. doi: 10.1016/j.autneu.2009.07.015. Epub 2009 Aug 9. Review.
PMID: 19666242
Analgesic properties of S100A9 C-terminal domain: a mechanism dependent on calcium channel inhibition.
Dale CS, Altier C, Cenac N, Giorgi R, Juliano MA, Juliano L, Zamponi GW, Vergnolle N.
Fundam Clin Pharmacol. 2009 Aug;23(4):427-38. doi: 10.1111/j.1472-8206.2009.00686.x. Epub 2009 Jun 8.
PMID: 19515068
Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway.
Khoufache K, LeBouder F, Morello E, Laurent F, Riffault S, Andrade-Gordon P, Boullier S, Rousset P, Vergnolle N, Riteau B.
J Immunol. 2009 Jun 15;182(12):7795-802. doi: 10.4049/jimmunol.0803743.
PMID: 19494303 Free Article
Protease-activated receptors as drug targets in inflammation and pain.
Vergnolle N.
Pharmacol Ther. 2009 Sep;123(3):292-309. doi: 10.1016/j.pharmthera.2009.05.004. Epub 2009 May 28. Review.
PMID: 19481569
Triggering of proteinase-activated receptor 4 leads to joint pain and inflammation in mice.
McDougall JJ, Zhang C, Cellars L, Joubert E, Dixon CM, Vergnolle N.
Arthritis Rheum. 2009 Mar;60(3):728-37. doi: 10.1002/art.24300.
PMID: 19248120 Free Article
Development, plasticity and modulation of visceral afferents.
Christianson JA, Bielefeldt K, Altier C, Cenac N, Davis BM, Gebhart GF, High KW, Kollarik M, Randich A, Undem B, Vergnolle N.
Brain Res Rev. 2009 Apr;60(1):171-86. doi: 10.1016/j.brainresrev.2008.12.004. Epub 2008 Dec 25. Review.
PMID: 19150371 Free PMC Article
Neutrophil-mediated activation of epithelial protease-activated receptors-1 and -2 regulates barrier function and transepithelial migration.
Chin AC, Lee WY, Nusrat A, Vergnolle N, Parkos CA.
J Immunol. 2008 Oct 15;181(8):5702-10.
PMID: 18832729 Free PMC Article
Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms.
Cenac N, Altier C, Chapman K, Liedtke W, Zamponi G, Vergnolle N.
Gastroenterology. 2008 Sep;135(3):937-46, 946.e1-2. doi: 10.1053/j.gastro.2008.05.024. Epub 2008 May 10.
PMID: 18565335
Derivatized 2-furoyl-LIGRLO-amide, a versatile and selective probe for proteinase-activated receptor 2: binding and visualization.
Hollenberg MD, Renaux B, Hyun E, Houle S, Vergnolle N, Saifeddine M, Ramachandran R.
J Pharmacol Exp Ther. 2008 Aug;326(2):453-62. doi: 10.1124/jpet.108.136432. Epub 2008 May 13.
PMID: 18477767 Free Article
Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection.
Feld M, Shpacovitch VM, Ehrhardt C, Kerkhoff C, Hollenberg MD, Vergnolle N, Ludwig S, Steinhoff M.
J Immunol. 2008 May 15;180(10):6903-10.
PMID: 18453611 Free Article
Protease signaling to G protein-coupled receptors: implications for inflammation and pain.
Dale C, Vergnolle N.
J Recept Signal Transduct Res. 2008;28(1-2):29-37. doi: 10.1080/10799890801941913 . Review.
PMID: 18437628
Proteinase-activated receptors (PARs) in infection and inflammation in the gut.
Vergnolle N.
Int J Biochem Cell Biol. 2008;40(6-7):1219-27. doi: 10.1016/j.biocel.2008.01.016. Epub 2008 Jan 20. Review.
PMID: 18313348
Mechanisms underlying the nociceptive and inflammatory responses induced by trypsin in the mouse paw.
Paszcuk AF, Quintão NL, Fernandes ES, Juliano L, Chapman K, Andrade-Gordon P, Campos MM, Vergnolle N, Calixto JB.
Eur J Pharmacol. 2008 Feb 26;581(1-2):204-15. Epub 2007 Nov 23.
PMID: 18083162
Intrathecal administration of proteinase-activated receptor-2 agonists produces hyperalgesia by exciting the cell bodies of primary sensory neurons.
Alier KA, Endicott JA, Stemkowski PL, Cenac N, Cellars L, Chapman K, Andrade-Gordon P, Vergnolle N, Smith PA.
J Pharmacol Exp Ther. 2008 Jan;324(1):224-33. Epub 2007 Oct 5.
PMID: 17921188 Free Article
Proteinase-activated receptor-2 exerts protective and pathogenic cell type-specific effects in Alzheimer's disease.
Afkhami-Goli A, Noorbakhsh F, Keller AJ, Vergnolle N, Westaway D, Jhamandas JH, Andrade-Gordon P, Hollenberg MD, Arab H, Dyck RH, Power C.
J Immunol. 2007 Oct 15;179(8):5493-503.
PMID: 17911636 Free Article
Agonists of proteinase-activated receptor-2 affect transendothelial migration and apoptosis of human neutrophils.
Shpacovitch VM, Seeliger S, Huber-Lang M, Balkow S, Feld M, Hollenberg MD, Sarma VJ, Ward PA, Strey A, Gerke V, Sommerhoff CP, Vergnolle N, Steinhoff M.
Exp Dermatol. 2007 Oct;16(10):799-806.
PMID: 17845211
Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia.
Knecht W, Cottrell GS, Amadesi S, Mohlin J, Skåregärde A, Gedda K, Peterson A, Chapman K, Hollenberg MD, Vergnolle N, Bunnett NW.
J Biol Chem. 2007 Sep 7;282(36):26089-100. Epub 2007 Jul 10.
PMID: 17623652 Free Article
Differential role of N-type calcium channel splice isoforms in pain.
Altier C, Dale CS, Kisilevsky AE, Chapman K, Castiglioni AJ, Matthews EA, Evans RM, Dickenson AH, Lipscombe D, Vergnolle N, Zamponi GW.
J Neurosci. 2007 Jun 13;27(24):6363-73.
PMID: 17567797 Free Article
Citrobacter rodentium infection causes iNOS-independent intestinal epithelial dysfunction in mice.
Skinn AC, Vergnolle N, Zamuner SR, Wallace JL, Cellars L, MacNaughton WK, Sherman PM.
Can J Physiol Pharmacol. 2006 Dec;84(12):1301-12.
PMID: 17487239
Proteinase-activated receptor-2 (PAR2): a tumor suppressor in skin carcinogenesis.
Rattenholl A, Seeliger S, Buddenkotte J, Schön M, Schön MP, Ständer S, Vergnolle N, Steinhoff M.
J Invest Dermatol. 2007 Sep;127(9):2245-52. Epub 2007 May 3.
PMID: 17476297 Free Article
Role for protease activity in visceral pain in irritable bowel syndrome.
Cenac N, Andrews CN, Holzhausen M, Chapman K, Cottrell G, Andrade-Gordon P, Steinhoff M, Barbara G, Beck P, Bunnett NW, Sharkey KA, Ferraz JG, Shaffer E, Vergnolle N.
J Clin Invest. 2007 Mar;117(3):636-47. Epub 2007 Feb 15.
PMID: 17304351 Free PMC Article
Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice.
Grant AD, Cottrell GS, Amadesi S, Trevisani M, Nicoletti P, Materazzi S, Altier C, Cenac N, Zamponi GW, Bautista-Cruz F, Lopez CB, Joseph EK, Levine JD, Liedtke W, Vanner S, Vergnolle N, Geppetti P, Bunnett NW.
J Physiol. 2007 Feb 1;578(Pt 3):715-33. Epub 2006 Nov 23.
PMID: 17124270 Free PMC Article
A role for proteinase-activated receptor-1 in inflammatory bowel diseases.
Vergnolle N, Cellars L, Mencarelli A, Rizzo G, Swaminathan S, Beck P, Steinhoff M, Andrade-Gordon P, Bunnett NW, Hollenberg MD, Wallace JL, Cirino G, Fiorucci S.
J Clin Invest. 2006 Jul;116(7):2056. No abstract available.
PMID: 16881139 Free PMC Article
Protective effect of proteinase-activated receptor 2 activation on motility impairment and tissue damage induced by intestinal ischemia/reperfusion in rodents.
Cattaruzza F, Cenac N, Barocelli E, Impicciatore M, Hyun E, Vergnolle N, Sternini C.
Am J Pathol. 2006 Jul;169(1):177-88.
PMID: 16816371 Free PMC Article
Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs).
Oikonomopoulou K, Hansen KK, Saifeddine M, Vergnolle N, Tea I, Blaber M, Blaber SI, Scarisbrick I, Diamandis EP, Hollenberg MD.
Biol Chem. 2006 Jun;387(6):817-24.
PMID: 16800746
Proteinase-mediated cell signalling: targeting proteinase-activated receptors (PARs) by kallikreins and more.
Oikonomopoulou K, Hansen KK, Saifeddine M, Vergnolle N, Tea I, Diamandis EP, Hollenberg MD.
Biol Chem. 2006 Jun;387(6):677-85. Review.
PMID: 16800728
Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice.
Amadesi S, Cottrell GS, Divino L, Chapman K, Grady EF, Bautista F, Karanjia R, Barajas-Lopez C, Vanner S, Vergnolle N, Bunnett NW.
J Physiol. 2006 Sep 1;575(Pt 2):555-71. Epub 2006 Jun 22.
PMID: 16793902 Free PMC Article
Proteinase-activated receptors (PARs): crossroads between innate immunity and coagulation.
Cirino G, Vergnolle N.
Curr Opin Pharmacol. 2006 Aug;6(4):428-34. Epub 2006 Jun 13. Review.
PMID: 16777485
Protease-activated receptor-2 activation: a major role in the pathogenesis of Porphyromonas gingivalis infection.
Holzhausen M, Spolidorio LC, Ellen RP, Jobin MC, Steinhoff M, Andrade-Gordon P, Vergnolle N.
Am J Pathol. 2006 Apr;168(4):1189-99.
PMID: 16565494 Free PMC Article
Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis.
Noorbakhsh F, Tsutsui S, Vergnolle N, Boven LA, Shariat N, Vodjgani M, Warren KG, Andrade-Gordon P, Hollenberg MD, Power C.
J Exp Med. 2006 Feb 20;203(2):425-35. Epub 2006 Feb 13.
PMID: 16476770 Free PMC Article
Functional characterization and expression analysis of the proteinase-activated receptor-2 in human cutaneous mast cells.
Moormann C, Artuc M, Pohl E, Varga G, Buddenkotte J, Vergnolle N, Brehler R, Henz BM, Schneider SW, Luger TA, Steinhoff M.
J Invest Dermatol. 2006 Apr;126(4):746-55.
PMID: 16470180 Free Article
Endogenous opioid-mediated antinociception in cholestatic mice is peripherally, not centrally, mediated.
Nelson L, Vergnolle N, D'Mello C, Chapman K, Le T, Swain MG.
J Hepatol. 2006 Jun;44(6):1141-9. Epub 2005 Dec 27.
PMID: 16466825
Neonatal immune challenge alters nociception in the adult rat.
Boissé L, Spencer SJ, Mouihate A, Vergnolle N, Pittman QJ.
Pain. 2005 Dec 15;119(1-3):133-41. Epub 2005 Nov 16.
PMID: 16297551
Proteinase-activated receptor-1 is an anti-inflammatory signal for colitis mediated by a type 2 immune response.
Cenac N, Cellars L, Steinhoff M, Andrade-Gordon P, Hollenberg MD, Wallace JL, Fiorucci S, Vergnolle N.
Inflamm Bowel Dis. 2005 Sep;11(9):792-8.
PMID: 16116312
Neutrophils and the kallikrein-kinin system in proteinase-activated receptor 4-mediated inflammation in rodents.
Houle S, Papez MD, Ferazzini M, Hollenberg MD, Vergnolle N.
Br J Pharmacol. 2005 Nov;146(5):670-8.
PMID: 16100525 Free PMC Article
Protease-activated receptors and inflammatory hyperalgesia.
Vergnolle N.
Mem Inst Oswaldo Cruz. 2005 Mar;100 Suppl 1:173-6. Epub 2005 Jun 14. Review.
PMID: 15962118 Free Article
A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis.
Hansen KK, Sherman PM, Cellars L, Andrade-Gordon P, Pan Z, Baruch A, Wallace JL, Hollenberg MD, Vergnolle N.
Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8363-8. Epub 2005 May 26.
PMID: 15919826 Free PMC Article
Proteinase-activated receptor-2 induction by neuroinflammation prevents neuronal death during HIV infection.
Noorbakhsh F, Vergnolle N, McArthur JC, Silva C, Vodjgani M, Andrade-Gordon P, Hollenberg MD, Power C.
J Immunol. 2005 Jun 1;174(11):7320-9.
PMID: 15905579 Free Article
Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis.
Chou MM, Vergnolle N, McDougall JJ, Wallace JL, Marty S, Teskey V, Buret AG.
Exp Biol Med (Maywood). 2005 Apr;230(4):255-62.
PMID: 15792947
Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response.
Steinhoff M, Buddenkotte J, Shpacovitch V, Rattenholl A, Moormann C, Vergnolle N, Luger TA, Hollenberg MD.
Endocr Rev. 2005 Feb;26(1):1-43. Review.
PMID: 15689571
Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B.
Buddenkotte J, Stroh C, Engels IH, Moormann C, Shpacovitch VM, Seeliger S, Vergnolle N, Vestweber D, Luger TA, Schulze-Osthoff K, Steinhoff M.
J Invest Dermatol. 2005 Jan;124(1):38-45.
PMID: 15654951 Free Article
A role for proteinase-activated receptor-1 in inflammatory bowel diseases.
Vergnolle N, Cellars L, Mencarelli A, Rizzo G, Swaminathan S, Beck P, Steinhoff M, Andrade-Gordon P, Bunnett NW, Hollenberg MD, Wallace JL, Cirino G, Fiorucci S.
J Clin Invest. 2004 Nov;114(10):1444-56. Retraction in: Vergnolle N, Cellars L, Mencarelli A, Rizzo G, Swaminathan S, Beck P, Steinhoff M, Andrade-Gordon P, Bunnett NW, Hollenberg MD, Wallace JL, Cirino G, Fiorucci S. J Clin Invest. 2006 Jul;116(7):2056.
PMID: 15545995 Free PMC Article
Annexin 1 is secreted in situ during ulcerative colitis in humans.
Vergnolle N, Pagès P, Guimbaud R, Chaussade S, Buéno L, Escourrou J, Coméra C.
Inflamm Bowel Dis. 2004 Sep;10(5):584-92.
PMID: 15472519
Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo.
Hollenberg MD, Saifeddine M, Sandhu S, Houle S, Vergnolle N.
Br J Pharmacol. 2004 Oct;143(4):443-54. Epub 2004 Sep 27.
PMID: 15451771 Free PMC Article
Activation of proteinase-activated receptor-1 inhibits neurally evoked chloride secretion in the mouse colon in vitro.
Buresi MC, Vergnolle N, Sharkey KA, Keenan CM, Andrade-Gordon P, Cirino G, Cirillo D, Hollenberg MD, MacNaughton WK.
Am J Physiol Gastrointest Liver Physiol. 2005 Feb;288(2):G337-45. Epub 2004 Sep 2.
PMID: 15345469 Free Article
Proteinase-activated receptor 2 activation modulates guinea-pig mesenteric lymphatic vessel pacemaker potential and contractile activity.
Chan AK, Vergnolle N, Hollenberg MD, von der Weid PY.
J Physiol. 2004 Oct 15;560(Pt 2):563-76. Epub 2004 Aug 26.
PMID: 15331674 Free PMC Article
Anti-inflammatory effects of nitric oxide-releasing hydrocortisone NCX 1022, in a murine model of contact dermatitis.
Hyun E, Bolla M, Steinhoff M, Wallace JL, Soldato PD, Vergnolle N.
Br J Pharmacol. 2004 Nov;143(5):618-25. Epub 2004 Aug 16.
PMID: 15313880 Free PMC Article
PAR2 activation alters colonic paracellular permeability in mice via IFN-gamma-dependent and -independent pathways.
Cenac N, Chin AC, Garcia-Villar R, Salvador-Cartier C, Ferrier L, Vergnolle N, Buret AG, Fioramonti J, Bueno L.
J Physiol. 2004 Aug 1;558(Pt 3):913-25. Epub 2004 Jun 11.
PMID: 15194744 Free PMC Article
Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.
Amadesi S, Nie J, Vergnolle N, Cottrell GS, Grady EF, Trevisani M, Manni C, Geppetti P, McRoberts JA, Ennes H, Davis JB, Mayer EA, Bunnett NW.
J Neurosci. 2004 May 5;24(18):4300-12.
PMID: 15128844 Free Article
Modulation of visceral pain and inflammation by protease-activated receptors.
Vergnolle N.
Br J Pharmacol. 2004 Apr;141(8):1264-74. Epub 2004 Mar 29. Review.
PMID: 15051630 Free PMC Article
Proteinase-activated receptors in the nervous system.
Noorbakhsh F, Vergnolle N, Hollenberg MD, Power C.
Nat Rev Neurosci. 2003 Dec;4(12):981-90. Review.
PMID: 14682360
Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism.
Nguyen C, Coelho AM, Grady E, Compton SJ, Wallace JL, Hollenberg MD, Cenac N, Garcia-Villar R, Bueno L, Steinhoff M, Bunnett NW, Vergnolle N.
Can J Physiol Pharmacol. 2003 Sep;81(9):920-7.
PMID: 14614531
The enteric nervous system in inflammation and pain: the role of proteinase-activated receptors.
Vergnolle N.
Can J Gastroenterol. 2003 Oct;17(10):589-92. Review.
PMID: 14571293
Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo.
Seeliger S, Derian CK, Vergnolle N, Bunnett NW, Nawroth R, Schmelz M, Von Der Weid PY, Buddenkotte J, Sunderkötter C, Metze D, Andrade-Gordon P, Harms E, Vestweber D, Luger TA, Steinhoff M.
FASEB J. 2003 Oct;17(13):1871-85.
PMID: 14519665 Free Article
Proteinase-activated receptor 1 activation induces epithelial apoptosis and increases intestinal permeability.
Chin AC, Vergnolle N, MacNaughton WK, Wallace JL, Hollenberg MD, Buret AG.
Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11104-9. Epub 2003 Sep 5.
PMID: 12960392 Free PMC Article
Proteinase-activated receptors: novel signals for peripheral nerves.
Vergnolle N, Ferazzini M, D'Andrea MR, Buddenkotte J, Steinhoff M.
Trends Neurosci. 2003 Sep;26(9):496-500. Review.
PMID: 12948661
Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability.
Cenac N, Garcia-Villar R, Ferrier L, Larauche M, Vergnolle N, Bunnett NW, Coelho AM, Fioramonti J, Bueno L.
J Immunol. 2003 Apr 15;170(8):4296-300.
PMID: 12682265 Free Article
Up-regulation of proteinase-activated receptor 1 expression in astrocytes during HIV encephalitis.
Boven LA, Vergnolle N, Henry SD, Silva C, Imai Y, Holden J, Warren K, Hollenberg MD, Power C.
J Immunol. 2003 Mar 1;170(5):2638-46.
PMID: 12594292 Free Article
Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2.
Cenac N, Coelho AM, Nguyen C, Compton S, Andrade-Gordon P, MacNaughton WK, Wallace JL, Hollenberg MD, Bunnett NW, Garcia-Villar R, Bueno L, Vergnolle N.
Am J Pathol. 2002 Nov;161(5):1903-15.
PMID: 12414536 Free PMC Article
Characterization of thrombin-induced leukocyte rolling and adherence: a potential proinflammatory role for proteinase-activated receptor-4.
Vergnolle N, Derian CK, D'Andrea MR, Steinhoff M, Andrade-Gordon P.
J Immunol. 2002 Aug 1;169(3):1467-73.
PMID: 12133973 Free Article
Proteinases and proteinase-activated receptor 2: a possible role to promote visceral hyperalgesia in rats.
Coelho AM, Vergnolle N, Guiard B, Fioramonti J, Bueno L.
Gastroenterology. 2002 Apr;122(4):1035-47.
PMID: 11910355
Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli.
Asfaha S, Brussee V, Chapman K, Zochodne DW, Vergnolle N.
Br J Pharmacol. 2002 Mar;135(5):1101-6.
PMID: 11877315 Free PMC Article
